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Annu Rev Genet. 2002;36:455-88. Epub 2002 Jun 11.

Understanding the function of actin-binding proteins through genetic analysis of Drosophila oogenesis.

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Departments of Genetics Yale University School of Medicine, P.O. Box 208005, New Haven, Connecticut 06520-8005, USA.


Much of our knowledge of the actin cytoskeleton has been derived from biochemical and cell biological approaches, through which actin-binding proteins have been identified and their in vitro interactions with actin have been characterized. The study of actin-binding proteins (ABPs) in genetic model systems has become increasingly important for validating and extending our understanding of how these proteins function. New ABPs have been identified through genetic screens, and genetic results have informed the interpretation of in vitro experiments. In this review, we describe the molecular and ultrastructural characteristics of the actin cytoskeleton in the Drosophila ovary, and discuss recent genetic analyses of actin-binding proteins that are required for oogenesis.

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