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Gut. 2002 Jul;51 Suppl 1:i29-33.

Role of the brain and sensory pathways in gastrointestinal sensory disorders in humans.

Author information

1
Vanderbilt University Medical Center, Nashville 37232-5340, USA. howard.Mertz@mcmail.vanderbilt.edu

Abstract

Several features of the irritable bowel syndrome (IBS) suggest involvement of the emotional limbic system in the brain. Abnormalities which upregulate afferent (sensory) signal intensity anywhere in this system, from the gastrointestinal tract to the brain, could induce hypersensitivity, leading to the pain and discomfort that characterise IBS and other functional disorders. Functional gastrointestinal disorders are likely to be heterogeneous given the complexity of the afferent system, and a number of different perturbations are possible. Intestinal hypersensitivity to pain and discomfort and associated reflex alterations in motility might explain the symptoms of functional bowel diseases.

PMID:
12077061
PMCID:
PMC1867728
DOI:
10.1136/gut.51.suppl_1.i29
[Indexed for MEDLINE]
Free PMC Article

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