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FEMS Microbiol Lett. 2002 Jun 4;211(2):219-23.

AbrB is a regulator of the sigma(W) regulon in Bacillus subtilis.

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Department of Oral and Craniofacial Biological Sciences, Dental School, University of Maryland, 666 W. Baltimore St., Room 4-C-30, Baltimore, MD 21201, USA.


The Bacillus subtilis global regulator AbrB was found to negatively control expression of sigW and genes of the sigma(W) regulon. AbrB bound to DNA regions in the autoregulatory sigW promoter and to some, but not all, of the other sigma(W)-dependent promoters in B. subtilis. Defects in antibiotic resistance properties caused by spo0A mutations are at least partially correlated with AbrB repression of the sigma(W) regulon.

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