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Dev Cell. 2001 Dec;1(6):733-42.

Morphological coupling in development: lessons from prokaryotes.

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Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.


At certain junctures in development, gene transcription is coupled to the completion of landmark morphological events. We refer to this dependence on morphogenesis for gene expression as "morphological coupling." Three examples of morphological coupling in prokaryotes are reviewed in which the activation of a transcription factor is tied to the assembly of a critically important structure in development.

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