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Curr Biol. 2001 May 1;11(9):R356-60.

Human disease: calcium signaling in polycystic kidney disease.

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Department of Internal Medicine, Yale University School of Medicine, Connecticut, New Haven, USA.


Polycystic kidney disease results from loss of function of either of two novel proteins, polycystin-1 or polycystin-2. Recent studies show that intracellular calcium signaling is important in kidney development, and define defects in this signaling pathway as the basis of cyst formation in polycystic kidney disease.

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