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Science. 2000 Nov 10;290(5494):1170-4.

NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation.

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1
Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.

Erratum in

  • Science 2001 Mar 9;291(5510):1902.

Abstract

The hippocampal CA1 region is crucial for converting new memories into long-term memories, a process believed to continue for week(s) after initial learning. By developing an inducible, reversible, and CA1-specific knockout technique, we could switch N-methyl-D-aspartate (NMDA) receptor function off or on in CA1 during the consolidation period. Our data indicate that memory consolidation depends on the reactivation of the NMDA receptor, possibly to reinforce site-specific synaptic modifications to consolidate memory traces. Such a synaptic reinforcement process may also serve as a cellular means by which the new memory is transferred from the hippocampus to the cortex for permanent storage.

PMID:
11073458
DOI:
10.1126/science.290.5494.1170
[Indexed for MEDLINE]
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