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Curr Opin Chem Biol. 2000 Feb;4(1):47-53.

Small-molecule inhibitors of the cell cycle.

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Departments of Molecular, Cellular, and Developmental Biology and Pharmacology, Yale University, New Haven, CT 06520-8103, USA. craig.


The cell cycle remains an attractive target for the development of small-molecule inhibitors for use as both novel chemotherapeutics and research probes. Given the importance of cytoskeletal dynamics and cyclin-dependent kinases for cell-cycle progression, much interest has focused on the identification of anti-mitotic agents and kinase inhibitors. However recent advances in cell-based screening technologies and an increased interest in inhibitors with greater specificity are beginning to influence the search for novel cell-cycle inhibitors.

[Indexed for MEDLINE]

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