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Curr Top Dev Biol. 1999;46:179-200.

Fibroblast growth factor signaling regulates growth and morphogenesis at multiple steps during brain development.

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1
Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Abstract

The fibroblast growth factor (FGF) family comprises several members with distinct patterns of expression in the developing central nervous system. FGFs regulate the early specification and the subsequent growth of central nervous system regions. These different actions require the coordinated activation of distinct sets of target genes by FGFs at the appropriate stage of development. The role of FGF2 in the growth and morphogenesis of the cerebral cortex is reviewed in detail. The cellular and molecular mechanisms that underlie the action of FGF2 on cortical development are discussed.

PMID:
10417880
[Indexed for MEDLINE]

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