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Euro Surveill. 2019 Sep;24(36). doi: 10.2807/1560-7917.ES.2019.24.36.1900528.

Two cases of multidrug-resistant Neisseria gonorrhoeae related to travel in south-eastern Asia, France, June 2019.

Poncin T1,2,3, Merimeche M1,2,3, Braille A1,2,3, Mainardis M1,2,3, Bebear C4,5, Jacquier H1,2,3, Berçot B1,2,3.

Author information

1
Paris University, INSERM, IAME, Paris, France.
2
French National Reference Centre for bacterial sexually transmitted infections, Associated laboratory for gonococci, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
3
Infectious Agents Department, Saint Louis Hospital, Assistance Publique - Hôpitaux de Paris (APHP), Paris, France.
4
Centre Hospitalier Universitaire de Bordeaux, French National Reference Centre for bacterial sexually transmitted infections, Bordeaux, France.
5
University of Bordeaux, USC EA 3671, Mycoplasmal and chlamydial infections in humans, Bordeaux, France.

Abstract

We report two cases of multidrug-resistant Neisseria gonorrhoeae urogenital infection with ceftriaxone resistance in a heterosexual couple in south-western France who were successfully treated with a single, high dose of intramuscular ceftriaxone (1 g). Whole genome sequencing of isolate F91 identified MLST13871, NG-MAST1086, NG-STAR233. Patient history revealed the isolate F91 was most likely acquired during a trip to Cambodia and belongs to the successful multidrug-resistant FC428 Asian clone.

KEYWORDS:

Gonorrhoea; antimicrobial resistance; high dose anti-microbial treatment; travel; whole-genome sequencing

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