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Euro Surveill. 2018 Jan;23(3). doi: 10.2807/1560-7917.ES.2018.23.3.17-00838.

Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017.

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Laboratory of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden.
Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
The Public Health Agency of Sweden, Solna, Stockholm, Sweden.
Clinical Research Centre, Sormland county council, Uppsala University, Uppsala, Sweden.
Department of Infectious diseases, Eskilstuna, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.


Tick-borne encephalitis virus (TBEV) is an important European vaccine-preventable pathogen. Discrimination of vaccine-induced antibodies from those elicited by infection is important. We studied anti-TBEV IgM/IgG responses, including avidity and neutralisation, by multiplex serology in 50 TBEV patients and 50 TBEV vaccinees. Infection induced antibodies reactive to both whole virus (WV) and non-structural protein 1 (NS1) in 48 clinical cases, whereas 47 TBEV vaccinees had WV, but not NS1 antibodies, enabling efficient discrimination of infection/vaccination.


Tick-borne encephalitis (TBE); diagnostics; vaccine-preventable diseases; vaccines and immunisation; viral encephalitis; zoonotic infections

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