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Euro Surveill. 2018 Jan;23(3). doi: 10.2807/1560-7917.ES.2018.23.3.17-00838.

Distinction between serological responses following tick-borne encephalitis virus (TBEV) infection vs vaccination, Sweden 2017.

Author information

1
Laboratory of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden.
2
Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden.
3
The Public Health Agency of Sweden, Solna, Stockholm, Sweden.
4
Clinical Research Centre, Sormland county council, Uppsala University, Uppsala, Sweden.
5
Department of Infectious diseases, Eskilstuna, Sweden.
6
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Abstract

Tick-borne encephalitis virus (TBEV) is an important European vaccine-preventable pathogen. Discrimination of vaccine-induced antibodies from those elicited by infection is important. We studied anti-TBEV IgM/IgG responses, including avidity and neutralisation, by multiplex serology in 50 TBEV patients and 50 TBEV vaccinees. Infection induced antibodies reactive to both whole virus (WV) and non-structural protein 1 (NS1) in 48 clinical cases, whereas 47 TBEV vaccinees had WV, but not NS1 antibodies, enabling efficient discrimination of infection/vaccination.

KEYWORDS:

Tick-borne encephalitis (TBE); diagnostics; vaccine-preventable diseases; vaccines and immunisation; viral encephalitis; zoonotic infections

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