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Euro Surveill. 2016 Jun 16;21(24). doi: 10.2807/1560-7917.ES.2016.21.24.30258.

Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016.

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Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.


An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.


A(H1N1)pdm09; influenza virus; neuraminidase inhibitor; oseltamivir-resistant influenza virus; peramivir-resistant influenza virus

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