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ChemMedChem. 2012 May;7(5):761-5. doi: 10.1002/cmdc.201200038. Epub 2012 Feb 29.

Structural determination of NSC 670224, synthesis of analogues and biological evaluation.

Author information

1
Department of Chemistry and Biochemistry, University of California, Santa Cruz (UCSC), Santa Cruz, CA 95064, USA.

Abstract

Follow my lead! NSC 670224, previously shown to be toxic to Saccharomyces cerevisiae at low micromolar concentrations, potentially acts via a mechanism of action related to that of tamoxifen (NSC 180973), breast cancer drug. The structure of NSC 670224, previously thought to be a 2,4-dichloro arene, was established as the 3,4-dichloro arene, and a focused library of analogues were synthesized and biologically evaluated.

PMID:
22378491
PMCID:
PMC3516922
DOI:
10.1002/cmdc.201200038
[Indexed for MEDLINE]
Free PMC Article

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