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Arch Bronconeumol. 2017 Dec;53(12):675-681. doi: 10.1016/j.arbres.2017.04.016. Epub 2017 Jun 15.

Small Cell Lung Cancer. Methodology and Preliminary Results of the SMALL CELL Study.

[Article in English, Spanish]

Author information

1
Servicio de Oncología, Complejo Hospitalario Universitario de Pontevedra, Pontevedra, España; Área de Medicina Preventiva y Salud Pública, Universidad de Santiago de Compostela, Santiago de Compostela, España.
2
Área de Medicina Preventiva y Salud Pública, Universidad de Santiago de Compostela, Santiago de Compostela, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España. Electronic address: alberto.ruano@usc.es.
3
Servicio de Neumología, Complejo Hospitalario Universitario de Vigo, Vigo, España.
4
Servicio de Neumología, Complejo Hospitalario Universitario de A Coruña, A Coruña, España.
5
Sección de Neumología, Complejo Asistencial de Ávila, Ávila, España.
6
Servicio de Neumología, Complejo Hospitalario de León, León, España.
7
Servicio de Oncología, Hospital Puerta de Hierro, Majadahonda, Madrid, España.
8
Servicio de Neumología, Hospital Lucus Augusti, Lugo, España.
9
Servicio de Neumología, Hospital de Ourense, Ourense, España.
10
Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, España.
11
Servicio de Oncología, Centro Oncológico de Galicia, A Coruña, España.
12
Servicio de Neumología, Hospital Central de Asturias, Oviedo, España.
13
Área de Medicina Preventiva y Salud Pública, Universidad de Santiago de Compostela, Santiago de Compostela, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España.

Abstract

INTRODUCTION:

Small cell lung cancer (SCLC) is the most aggressive histologic type of lung cancer, and accounts for approximately 10%-15% of all cases. Few studies have analyzed the effect of residential radon. Our aim is to determine the risk factors of SCLC.

METHODS:

We designed a multicenter, hospital-based case-control study with the participation of 11 hospitals in 4 autonomous communities.

RESULTS:

Results of the first 113 cases have been analyzed, 63 of which included residential radon measurements. Median age at diagnosis was 63 years; 11% of cases were younger than 50 years of age; 22% were women; 57% had extended disease; and 95% were smokers or former smokers. Median residential radon concentration was 128Bq/m3. Concentrations higher than 400Bq/m3 were found in 8% of cases. The only remarkable difference by gender was the percentage of never smokers, which was higher in women compared to men (P<.001). Radon concentration was higher in patients with stageIV disease (non-significant difference) and in individuals diagnosed at 63 years of age or older (P=.032).

CONCLUSIONS:

A high percentage of SCLC cases are diagnosed early and there is a predominance of disseminated disease at diagnosis. Residential radon seems to play an important role on the onset of this disease, with some cases having very high indoor radon concentrations.

KEYWORDS:

Case-control study; Cáncer de pulmón microcítico (de células pequeñas); Epidemiology; Epidemiología; Estudio de casos y controles; Radon; Radón; Small cell lung carcinoma

PMID:
28622908
DOI:
10.1016/j.arbres.2017.04.016
[Indexed for MEDLINE]
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