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Inhibition of pyruvate carboxylase by 1α,25-dihydroxyvitamin D promotes oxidative stress in early breast cancer progression.

Wilmanski T, Zhou X, Zheng W, Shinde A, Donkin SS, Wendt M, Burgess JR, Teegarden D.

Cancer Lett. 2017 Dec 28;411:171-181. doi: 10.1016/j.canlet.2017.09.045. Epub 2017 Oct 9.


MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.

Beloueche-Babari M, Wantuch S, Casals Galobart T, Koniordou M, Parkes HG, Arunan V, Chung YL, Eykyn TR, Smith PD, Leach MO.

Cancer Res. 2017 Nov 1;77(21):5913-5924. doi: 10.1158/0008-5472.CAN-16-2686. Epub 2017 Sep 18.


Striking Diversity in Holoenzyme Architecture and Extensive Conformational Variability in Biotin-Dependent Carboxylases.

Tong L.

Adv Protein Chem Struct Biol. 2017;109:161-194. doi: 10.1016/bs.apcsb.2017.04.006. Epub 2017 May 23. Review.


Increased carbon dioxide levels stimulate neutrophils to produce microparticles and activate the nucleotide-binding domain-like receptor 3 inflammasome.

Thom SR, Bhopale VM, Hu J, Yang M.

Free Radic Biol Med. 2017 May;106:406-416. doi: 10.1016/j.freeradbiomed.2017.03.005. Epub 2017 Mar 10.


Glucose and Intermediary Metabolism and Astrocyte-Neuron Interactions Following Neonatal Hypoxia-Ischemia in Rat.

Brekke E, Berger HR, Widerøe M, Sonnewald U, Morken TS.

Neurochem Res. 2017 Jan;42(1):115-132. doi: 10.1007/s11064-016-2149-9. Epub 2016 Dec 26. Review.


Lysine Restriction and Pyridoxal Phosphate Administration in a NADK2 Patient.

Tort F, Ugarteburu O, Torres MA, García-Villoria J, Girós M, Ruiz A, Ribes A.

Pediatrics. 2016 Nov;138(5). pii: e20154534. Epub 2016 Oct 18.


1α,25-dihydroxyvitamin D inhibits de novo fatty acid synthesis and lipid accumulation in metastatic breast cancer cells through down-regulation of pyruvate carboxylase.

Wilmanski T, Buhman K, Donkin SS, Burgess JR, Teegarden D.

J Nutr Biochem. 2017 Feb;40:194-200. doi: 10.1016/j.jnutbio.2016.11.006. Epub 2016 Dec 1.


The BRAF Inhibitor Vemurafenib Activates Mitochondrial Metabolism and Inhibits Hyperpolarized Pyruvate-Lactate Exchange in BRAF-Mutant Human Melanoma Cells.

Delgado-Goni T, Miniotis MF, Wantuch S, Parkes HG, Marais R, Workman P, Leach MO, Beloueche-Babari M.

Mol Cancer Ther. 2016 Dec;15(12):2987-2999. Epub 2016 Oct 7.


Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis.

Christen S, Lorendeau D, Schmieder R, Broekaert D, Metzger K, Veys K, Elia I, Buescher JM, Orth MF, Davidson SM, Grünewald TG, De Bock K, Fendt SM.

Cell Rep. 2016 Oct 11;17(3):837-848. doi: 10.1016/j.celrep.2016.09.042.


Long Noncoding RNA GCASPC, a Target of miR-17-3p, Negatively Regulates Pyruvate Carboxylase-Dependent Cell Proliferation in Gallbladder Cancer.

Ma MZ, Zhang Y, Weng MZ, Wang SH, Hu Y, Hou ZY, Qin YY, Gong W, Zhang YJ, Kong X, Wang JD, Quan ZW.

Cancer Res. 2016 Sep 15;76(18):5361-71. doi: 10.1158/0008-5472.CAN-15-3047. Epub 2016 Jul 22. Erratum in: Cancer Res. 2017 Mar 15;77(6):1503.


Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder.

Collardeau-Frachon S, Cordier MP, Rossi M, Guibaud L, Vianey-Saban C.

J Inherit Metab Dis. 2016 Sep;39(5):597-610. doi: 10.1007/s10545-016-9937-x. Epub 2016 Apr 22. Review.


Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain.

Cooper AJ, Jeitner TM.

Biomolecules. 2016 Mar 26;6(2). pii: E16. doi: 10.3390/biom6020016. Review.


Pyruvate Carboxylase Activates the RIG-I-like Receptor-Mediated Antiviral Immune Response by Targeting the MAVS signalosome.

Cao Z, Zhou Y, Zhu S, Feng J, Chen X, Liu S, Peng N, Yang X, Xu G, Zhu Y.

Sci Rep. 2016 Feb 24;6:22002. doi: 10.1038/srep22002.


Leptin regulates energy metabolism in MCF-7 breast cancer cells.

Blanquer-Rosselló Mdel M, Oliver J, Sastre-Serra J, Valle A, Roca P.

Int J Biochem Cell Biol. 2016 Mar;72:18-26. doi: 10.1016/j.biocel.2016.01.002. Epub 2016 Jan 6.


The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux.

Samuel VT, Shulman GI.

J Clin Invest. 2016 Jan;126(1):12-22. doi: 10.1172/JCI77812. Epub 2016 Jan 4. Review.


Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue.

González-Plaza JJ, Gutiérrez-Repiso C, García-Serrano S, Rodriguez-Pacheco F, Garrido-Sánchez L, Santiago-Fernández C, García-Arnés J, Moreno-Ruiz FJ, Rodríguez-Cañete A, García-Fuentes E.

Surg Obes Relat Dis. 2016 Feb;12(2):257-63. doi: 10.1016/j.soard.2015.07.007. Epub 2015 Jul 13.


Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.

Palm T, Bolognin S, Meiser J, Nickels S, Träger C, Meilenbrock RL, Brockhaus J, Schreitmüller M, Missler M, Schwamborn JC.

Sci Rep. 2015 Nov 6;5:16321. doi: 10.1038/srep16321.


Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism.

Lussey-Lepoutre C, Hollinshead KE, Ludwig C, Menara M, Morin A, Castro-Vega LJ, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo AP, Favier J, Tennant DA.

Nat Commun. 2015 Nov 2;6:8784. doi: 10.1038/ncomms9784.


Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

Cardaci S, Zheng L, MacKay G, van den Broek NJ, MacKenzie ED, Nixon C, Stevenson D, Tumanov S, Bulusu V, Kamphorst JJ, Vazquez A, Fleming S, Schiavi F, Kalna G, Blyth K, Strathdee D, Gottlieb E.

Nat Cell Biol. 2015 Oct;17(10):1317-26. doi: 10.1038/ncb3233. Epub 2015 Aug 24.


H2S-induced S-sulfhydration of pyruvate carboxylase contributes to gluconeogenesis in liver cells.

Ju Y, Untereiner A, Wu L, Yang G.

Biochim Biophys Acta. 2015 Nov;1850(11):2293-303. doi: 10.1016/j.bbagen.2015.08.003. Epub 2015 Aug 11.


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