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Items: 1 to 20 of 168

1.

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.

Krall EB, Wang B, Munoz DM, Ilic N, Raghavan S, Niederst MJ, Yu K, Ruddy DA, Aguirre AJ, Kim JW, Redig AJ, Gainor JF, Williams JA, Asara JM, Doench JG, Janne PA, Shaw AT, McDonald Iii RE, Engelman JA, Stegmeier F, Schlabach MR, Hahn WC.

Elife. 2017 Feb 1;6. pii: e18970. doi: 10.7554/eLife.18970.

2.

Stromal cues regulate the pancreatic cancer epigenome and metabolome.

Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1129-1134. doi: 10.1073/pnas.1620164114.

3.

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.

Sci Signal. 2017 Jan 3;10(460). pii: eaah4117. doi: 10.1126/scisignal.aah4117.

PMID:
28049764
4.

Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2.

Fantini D, Huang S, Asara JM, Bagchi S, Raychaudhuri P.

Mol Biol Cell. 2017 Jan 1;28(1):192-200. doi: 10.1091/mbc.E16-08-0573.

PMID:
28035050
5.

Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC.

Nature. 2016 Dec 1;540(7631):150. doi: 10.1038/nature19851. No abstract available.

PMID:
27706144
6.

SF2312 is a natural phosphonate inhibitor of enolase.

Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR 4th, Sun D, Prasad BA, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL.

Nat Chem Biol. 2016 Dec;12(12):1053-1058. doi: 10.1038/nchembio.2195.

PMID:
27723749
7.

Purine and pyrimidine metabolism: Convergent evidence on chronic antidepressant treatment response in mice and humans.

Park DI, Dournes C, Sillaber I, Uhr M, Asara JM, Gassen NC, Rein T, Ising M, Webhofer C, Filiou MD, Müller MB, Turck CW.

Sci Rep. 2016 Oct 12;6:35317. doi: 10.1038/srep35317.

8.

An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling.

Vinayagam A, Kulkarni MM, Sopko R, Sun X, Hu Y, Nand A, Villalta C, Moghimi A, Yang X, Mohr SE, Hong P, Asara JM, Perrimon N.

Cell Rep. 2016 Sep 13;16(11):3062-74. doi: 10.1016/j.celrep.2016.08.029.

9.

Fluoxetine Treatment Rescues Energy Metabolism Pathway Alterations in a Posttraumatic Stress Disorder Mouse Model.

Kao CY, He Z, Henes K, Asara JM, Webhofer C, Filiou MD, Khaitovich P, Wotjak CT, Turck CW.

Mol Neuropsychiatry. 2016 May;2(1):46-59. doi: 10.1159/000445377.

PMID:
27606320
10.

Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis.

Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5562-71. doi: 10.1073/pnas.1600204113.

PMID:
27588899
11.

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.

Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG Jr, Wei W.

Science. 2016 Aug 26;353(6302):929-32. doi: 10.1126/science.aad5755.

PMID:
27563096
12.

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion.

Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC.

Nature. 2016 Aug 25;536(7617):479-83.

PMID:
27509858
13.

Stem-loop binding protein is a multifaceted cellular regulator of HIV-1 replication.

Li M, Tucker LD, Asara JM, Cheruiyot CK, Lu H, Wu ZJ, Newstein MC, Dooner MS, Friedman J, Lally MA, Ramratnam B.

J Clin Invest. 2016 Aug 1;126(8):3117-29. doi: 10.1172/JCI82360.

14.

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth.

Cox AG, Hwang KL, Brown KK, Evason KJ, Beltz S, Tsomides A, O'Connor K, Galli GG, Yimlamai D, Chhangawala S, Yuan M, Lien EC, Wucherpfennig J, Nissim S, Minami A, Cohen DE, Camargo FD, Asara JM, Houvras Y, Stainier DY, Goessling W.

Nat Cell Biol. 2016 Aug;18(8):886-96. doi: 10.1038/ncb3389.

15.

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, Wulf GM.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4338-47. doi: 10.1073/pnas.1522223113.

16.

Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1.

Ricoult SJ, Dibble CC, Asara JM, Manning BD.

Mol Cell Biol. 2016 Aug 26;36(18):2384-95. doi: 10.1128/MCB.00163-16.

PMID:
27354064
17.

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.

Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, Tintara S, Trapnell C, Onder T, Loh YH, Mikkelsen T, Sliz P, Teitell MA, Asara JM, Marto JA, Li H, Collins JJ, Daley GQ.

Cell Stem Cell. 2016 Jul 7;19(1):66-80. doi: 10.1016/j.stem.2016.05.009.

PMID:
27320042
18.

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila.

Parkhitko AA, Binari R, Zhang N, Asara JM, Demontis F, Perrimon N.

Genes Dev. 2016 Jun 15;30(12):1409-22. doi: 10.1101/gad.282277.116.

19.

Endocrine and Metabolic Pathways Linked to Keratoconus: Implications for the Role of Hormones in the Stromal Microenvironment.

McKay TB, Hjortdal J, Sejersen H, Asara JM, Wu J, Karamichos D.

Sci Rep. 2016 May 9;6:25534. doi: 10.1038/srep25534.

20.

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A.

Nat Cell Biol. 2016 May;18(5):572-8. doi: 10.1038/ncb3341.

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