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Final Report of a Phase I Trial of Olaparib with Cetuximab and Radiation for Heavy Smoker Patients with Locally Advanced Head and Neck Cancer.

Karam SD, Reddy K, Blatchford P, Waxweiler T, DeLouize AM, Oweida A, Somerset H, Marshall C, Young C, Davies KD, Kane M, Tan AC, Wang XJ, Jimeno A, Aisner DL, Bowles DW, Raben D.

Clin Cancer Res. 2018 Jul 3. pii: clincanres.0467.2018. doi: 10.1158/1078-0432.CCR-18-0467. [Epub ahead of print]


CD44 facilitates epithelial to mesenchymal transition phenotypic change at acquisition of resistance to EGFR kinase inhibitors in lung cancer.

Suda K, Murakami I, Yu H, Kim J, Tan AC, Mizuuchi H, Rozeboom LM, Ellison K, Rivard CJ, Mitsudomi T, Hirsch FR.

Mol Cancer Ther. 2018 Jul 26. pii: molcanther.1279.2017. doi: 10.1158/1535-7163.MCT-17-1279. [Epub ahead of print]


Resistance to radiotherapy and PD-L1 blockade is mediated by TIM-3 upregulation and regulatory T-cell infiltration.

Oweida A, Hararah M, Phan AV, Binder DC, Bhatia S, Lennon S, Bukkapatnam S, Van Court B, Uyanga N, Darragh L, Kim HM, Raben D, Tan AC, Heasley L, Clambey ET, Nemenoff RA, Karam SD.

Clin Cancer Res. 2018 Jul 24. pii: clincanres.1038.2018. doi: 10.1158/1078-0432.CCR-18-1038. [Epub ahead of print]


GSEA-InContext: identifying novel and common patterns in expression experiments.

Powers RK, Goodspeed A, Pielke-Lombardo H, Tan AC, Costello JC.

Bioinformatics. 2018 Jul 1;34(13):i555-i564. doi: 10.1093/bioinformatics/bty271.


Innate Genetic Evolution of Lung Cancers and Spatial Heterogeneity: Analysis of Treatment-Naïve Lesions.

Suda K, Kim J, Murakami I, Rozeboom L, Shimoji M, Shimizu S, Rivard CJ, Mitsudomi T, Tan AC, Hirsch FR.

J Thorac Oncol. 2018 Jun 19. pii: S1556-0864(18)30692-0. doi: 10.1016/j.jtho.2018.05.039. [Epub ahead of print]


AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.

Pei S, Minhajuddin M, Adane B, Khan N, Stevens BM, Mack SC, Lai S, Rich JN, Inguva A, Shannon KM, Kim H, Tan AC, Myers JR, Ashton JM, Neff T, Pollyea DA, Smith CA, Jordan CT.

Cell Stem Cell. 2018 Jul 5;23(1):86-100.e6. doi: 10.1016/j.stem.2018.05.021. Epub 2018 Jun 14.


Systems Pharmacology-Based Approach of Connecting Disease Genes in Genome-Wide Association Studies with Traditional Chinese Medicine.

Kim J, Yoo M, Shin J, Kim H, Kang J, Tan AC.

Int J Genomics. 2018 Mar 22;2018:7697356. doi: 10.1155/2018/7697356. eCollection 2018.


IMPACT web portal: oncology database integrating molecular profiles with actionable therapeutics.

Hintzsche JD, Yoo M, Kim J, Amato CM, Robinson WA, Tan AC.

BMC Med Genomics. 2018 Apr 20;11(Suppl 2):26. doi: 10.1186/s12920-018-0350-1.


Exploring the molecular mechanisms of Traditional Chinese Medicine components using gene expression signatures and connectivity map.

Yoo M, Shin J, Kim H, Kim J, Kang J, Tan AC.

Comput Methods Programs Biomed. 2018 Apr 4. pii: S0169-2607(17)30851-9. doi: 10.1016/j.cmpb.2018.04.002. [Epub ahead of print]


Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers.

Pozdeyev N, Gay LM, Sokol ES, Hartmaier R, Deaver KE, Davis S, French JD, Borre PV, LaBarbera DV, Tan AC, Schweppe RE, Fishbein L, Ross JS, Haugen BR, Bowles DW.

Clin Cancer Res. 2018 Jul 1;24(13):3059-3068. doi: 10.1158/1078-0432.CCR-18-0373. Epub 2018 Apr 3.


Salivary Gland Cancer Patient-Derived Xenografts Enable Characterization of Cancer Stem Cells and New Gene Events Associated with Tumor Progression.

Keysar SB, Eagles JR, Miller B, Jackson BC, Chowdhury FN, Reisinger J, Chimed TS, Le PN, Morton JJ, Somerset HL, Varella-Garcia M, Tan AC, Song JI, Bowles DW, Reyland ME, Jimeno A.

Clin Cancer Res. 2018 Jun 15;24(12):2935-2943. doi: 10.1158/1078-0432.CCR-17-3871. Epub 2018 Mar 19.


GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems.

Lee BKB, Gan CP, Chang JK, Tan JL, Fadlullah MZ, Abdul Rahman ZA, Prime SS, Gutkind JS, Liew CS, Khang TF, Tan AC, Cheong SC.

J Dent Res. 2018 Jul;97(8):909-916. doi: 10.1177/0022034518759038. Epub 2018 Mar 7.


ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer.

Pilling AB, Kim J, Estrada-Bernal A, Zhou Q, Le AT, Singleton KR, Heasley LE, Tan AC, DeGregori J, Doebele RC.

Oncotarget. 2018 Jan 16;9(10):8823-8835. doi: 10.18632/oncotarget.24260. eCollection 2018 Feb 6.


Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.

Klauck PJ, Bagby SM, Capasso A, Bradshaw-Pierce EL, Selby HM, Spreafico A, Tentler JJ, Tan AC, Kim J, Arcaroli JJ, Purkey A, Messersmith WA, Kuida K, Eckhardt SG, Pitts TM.

BMC Cancer. 2018 Feb 5;18(1):136. doi: 10.1186/s12885-018-4036-z.


Deep learning of mutation-gene-drug relations from the literature.

Lee K, Kim B, Choi Y, Kim S, Shin W, Lee S, Park S, Kim S, Tan AC, Kang J.

BMC Bioinformatics. 2018 Jan 25;19(1):21. doi: 10.1186/s12859-018-2029-1.


A Pilot Study of Biomedical Text Comprehension using an Attention-Based Deep Neural Reader: Design and Experimental Analysis.

Kim S, Park D, Choi Y, Lee K, Kim B, Jeon M, Kim J, Tan AC, Kang J.

JMIR Med Inform. 2018 Jan 5;6(1):e2. doi: 10.2196/medinform.8751.


PAGER 2.0: an update to the pathway, annotated-list and gene-signature electronic repository for Human Network Biology.

Yue Z, Zheng Q, Neylon MT, Yoo M, Shin J, Zhao Z, Tan AC, Chen JY.

Nucleic Acids Res. 2018 Jan 4;46(D1):D668-D676. doi: 10.1093/nar/gkx1040.


Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model.

Scott AJ, Song EK, Bagby S, Purkey A, McCarter M, Gajdos C, Quackenbush KS, Cross B, Pitts TM, Tan AC, Eckhardt SG, Fenton H, Arcaroli J, Messersmith WA.

PLoS One. 2017 Nov 1;12(11):e0187173. doi: 10.1371/journal.pone.0187173. eCollection 2017.


ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms.

Couts KL, Bemis J, Turner JA, Bagby SM, Murphy D, Christiansen J, Hintzsche JD, Le A, Pitts TM, Wells K, Applegate A, Amato C, Multani P, Chow-Maneval E, Tentler JJ, Shellman YG, Rioth MJ, Tan AC, Gonzalez R, Medina T, Doebele RC, Robinson WA.

Mol Cancer Ther. 2018 Jan;17(1):222-231. doi: 10.1158/1535-7163.MCT-17-0472. Epub 2017 Oct 20.


Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.

Cavalli G, Koenders M, Kalabokis V, Kim J, Choon Tan A, Garlanda C, Mantovani A, Dagna L, Joosten LAB, Dinarello CA.

Rheumatology (Oxford). 2017 Dec 1;56(12):2256. doi: 10.1093/rheumatology/kex348. No abstract available.


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