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Items: 1 to 20 of 58

1.

Diplotype analysis of NUDT15 variants and 6-mercaptopurine sensitivity in pediatric lymphoid neoplasms.

Tsujimoto S, Osumi T, Uchiyama M, Shirai R, Moriyama T, Nishii R, Yamada Y, Kudo K, Sekiguchi M, Arakawa Y, Yoshida M, Uchiyama T, Terui K, Ito S, Koh K, Takita J, Ito E, Tomizawa D, Manabe A, Kiyokawa N, Yang JJ, Kato M.

Leukemia. 2018 Jul 2. doi: 10.1038/s41375-018-0190-1. [Epub ahead of print] No abstract available.

PMID:
29967377
2.

An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016.

Scheurer ME, Lupo PJ, Schüz J, Spector LG, Wiemels JL, Aplenc R, Gramatges MM, Schiffman JD, Pombo-de-Oliveira MS, Yang JJ, Heck JE, Metayer C, Orjuela-Grimm MA, Bona K, Aristizabal P, Austin MT, Rabin KR, Russell HV, Poplack DG.

Pediatr Hematol Oncol. 2018 May 8:1-16. doi: 10.1080/08880018.2018.1464088. [Epub ahead of print]

PMID:
29737912
3.

Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia.

Churchman ML, Qian M, Te Kronnie G, Zhang R, Yang W, Zhang H, Lana T, Tedrick P, Baskin R, Verbist K, Peters JL, Devidas M, Larsen E, Moore IM, Gu Z, Qu C, Yoshihara H, Porter SN, Pruett-Miller SM, Wu G, Raetz E, Martin PL, Bowman WP, Winick N, Mardis E, Fulton R, Stanulla M, Evans WE, Relling MV, Pui CH, Hunger SP, Loh ML, Handgretinger R, Nichols KE, Yang JJ, Mullighan CG.

Cancer Cell. 2018 May 14;33(5):937-948.e8. doi: 10.1016/j.ccell.2018.03.021. Epub 2018 Apr 19.

PMID:
29681510
4.

Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and antileukemic efficacy.

Nishii R, Moriyama T, Janke LJ, Yang W, Suiter CC, Lin TN, Li L, Kihira K, Toyoda H, Hofmann U, Schwab M, Takagi M, Morio T, Manabe A, Kham S, Jiang N, Rabin KR, Kato M, Koh K, Yeoh AE, Hori H, Yang JJ.

Blood. 2018 May 31;131(22):2466-2474. doi: 10.1182/blood-2017-11-815506. Epub 2018 Mar 23.

PMID:
29572377
5.

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.

Hnízda A, Fábry M, Moriyama T, Pachl P, Kugler M, Brinsa V, Ascher DB, Carroll WL, Novák P, Žaliová M, Trka J, Řezáčová P, Yang JJ, Veverka V.

Leukemia. 2018 Jun;32(6):1393-1403. doi: 10.1038/s41375-018-0073-5. Epub 2018 Feb 25.

PMID:
29535428
6.

Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia.

Zhu Y, Yin D, Su Y, Xia X, Moriyama T, Nishii R, Liao F, Zhang S, Guo X, Hou Q, Ai Y, Zhou X, Sun S, Zhang D, Zhang Y, Lin C, Deng Y, Lu X, Wang Y, Ma Z, Wang H, Liu B, Yang L, Zhang W, Yang JJ, Shu Y, Gao J, Xu H.

Haematologica. 2018 Jul;103(7):e293-e295. doi: 10.3324/haematol.2018.187658. Epub 2018 Mar 8. No abstract available.

7.

PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia.

Zhang Y, Gao Y, Zhang H, Zhang J, He F, Hnízda A, Qian M, Liu X, Gocho Y, Pui CH, Cheng T, Wang Q, Yang JJ, Zhu X, Liu X.

Blood. 2018 May 17;131(20):2256-2261. doi: 10.1182/blood-2017-11-817510. Epub 2018 Feb 6.

PMID:
29434033
8.

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

Qian M, Cao X, Devidas M, Yang W, Cheng C, Dai Y, Carroll A, Heerema NA, Zhang H, Moriyama T, Gastier-Foster JM, Xu H, Raetz E, Larsen E, Winick N, Bowman WP, Martin PL, Mardis ER, Fulton R, Zambetti G, Borowitz M, Wood B, Nichols KE, Carroll WL, Pui CH, Mullighan CG, Evans WE, Hunger SP, Relling MV, Loh ML, Yang JJ.

J Clin Oncol. 2018 Feb 20;36(6):591-599. doi: 10.1200/JCO.2017.75.5215. Epub 2018 Jan 4.

9.

Acquisition of Cholangiocarcinoma Traits during Advanced Hepatocellular Carcinoma Development in Mice.

Li L, Qian M, Chen IH, Finkelstein D, Onar-Thomas A, Johnson M, Calabrese C, Bahrami A, López-Terrada DH, Yang JJ, Tao WA, Zhu L.

Am J Pathol. 2018 Mar;188(3):656-671. doi: 10.1016/j.ajpath.2017.11.013. Epub 2017 Dec 15.

PMID:
29248454
10.

Pharmacogenomics in acute lymphoblastic leukemia.

Lee SHR, Yang JJ.

Best Pract Res Clin Haematol. 2017 Sep;30(3):229-236. doi: 10.1016/j.beha.2017.07.007. Epub 2017 Jul 27. Review.

PMID:
29050696
11.

Philadelphia Chromosome-like Acute Lymphoblastic Leukemia.

Pui CH, Roberts KG, Yang JJ, Mullighan CG.

Clin Lymphoma Myeloma Leuk. 2017 Aug;17(8):464-470. doi: 10.1016/j.clml.2017.03.299. Review.

PMID:
28842136
12.

Family-based exome-wide association study of childhood acute lymphoblastic leukemia among Hispanics confirms role of ARID5B in susceptibility.

Archer NP, Perez-Andreu V, Stoltze U, Scheurer ME, Wilkinson AV, Lin TN, Qian M, Goodings C, Swartz MD, Ranjit N, Rabin KR, Peckham-Gregory EC, Plon SE, de Alarcon PA, Zabriskie RC, Antillon-Klussmann F, Najera CR, Yang JJ, Lupo PJ.

PLoS One. 2017 Aug 17;12(8):e0180488. doi: 10.1371/journal.pone.0180488. eCollection 2017.

13.

Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations.

Nakka P, Archer NP, Xu H, Lupo PJ, Raphael BJ, Yang JJ, Ramachandran S.

Cancer Epidemiol Biomarkers Prev. 2017 Oct;26(10):1531-1539. doi: 10.1158/1055-9965.EPI-17-0360. Epub 2017 Jul 27.

14.

Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.

Moriyama T, Yang YL, Nishii R, Ariffin H, Liu C, Lin TN, Yang W, Lin DT, Yu CH, Kham S, Pui CH, Evans WE, Jeha S, Relling MV, Yeoh AE, Yang JJ.

Blood. 2017 Sep 7;130(10):1209-1212. doi: 10.1182/blood-2017-05-782383. Epub 2017 Jun 28.

PMID:
28659275
15.

Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.

Liu C, Janke LJ, Yang JJ, Evans WE, Schuetz JD, Relling MV.

Cancer Chemother Pharmacol. 2017 Aug;80(2):287-293. doi: 10.1007/s00280-017-3361-2. Epub 2017 Jun 16.

PMID:
28623449
16.

The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.

Moriyama T, Nishii R, Lin TN, Kihira K, Toyoda H, Jacob N, Kato M, Koh K, Inaba H, Manabe A, Schmiegelow K, Yang JJ, Hori H.

Pharmacogenet Genomics. 2017 Jun;27(6):236-239. doi: 10.1097/FPC.0000000000000282.

17.

Whole-genome noncoding sequence analysis in T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations.

Hu S, Qian M, Zhang H, Guo Y, Yang J, Zhao X, He H, Lu J, Pan J, Chang M, Du G, Lin TN, Kham SK, Quah TC, Ariffin H, Tan AM, Cheng Y, Li C, Yeoh AE, Pui CH, Skanderup AJ, Yang JJ.

Blood. 2017 Jun 15;129(24):3264-3268. doi: 10.1182/blood-2017-03-771162. Epub 2017 Apr 13. No abstract available.

18.

Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia.

Karol SE, Larsen E, Cheng C, Cao X, Yang W, Ramsey LB, Fernandez CA, McCorkle JR, Paugh SW, Autry RJ, Lopez-Lopez E, Diouf B, Jeha S, Pui CH, Raetz EA, Winick NJ, Carroll WL, Hunger SP, Loh ML, Devidas M, Evans WE, Yang JJ, Relling MV.

Leukemia. 2017 Jun;31(6):1325-1332. doi: 10.1038/leu.2017.24. Epub 2017 Jan 18.

19.

Genome-Wide Study Links PNPLA3 Variant With Elevated Hepatic Transaminase After Acute Lymphoblastic Leukemia Therapy.

Liu Y, Fernandez CA, Smith C, Yang W, Cheng C, Panetta JC, Kornegay N, Liu C, Ramsey LB, Karol SE, Janke LJ, Larsen EC, Winick N, Carroll WL, Loh ML, Raetz EA, Hunger SP, Devidas M, Yang JJ, Mullighan CG, Zhang J, Evans WE, Jeha S, Pui CH, Relling MV.

Clin Pharmacol Ther. 2017 Jan 16. doi: 10.1002/cpt.629. [Epub ahead of print]

20.

Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.

Qian M, Zhang H, Kham SK, Liu S, Jiang C, Zhao X, Lu Y, Goodings C, Lin TN, Zhang R, Moriyama T, Yin Z, Li Z, Quah TC, Ariffin H, Tan AM, Shen S, Bhojwani D, Hu S, Chen S, Zheng H, Pui CH, Yeoh AE, Yang JJ.

Genome Res. 2017 Feb;27(2):185-195. doi: 10.1101/gr.209163.116. Epub 2016 Nov 30.

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