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Items: 14


Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia.

Parajuli P, Kumar S, Loumaye A, Singh P, Eragamreddy S, Nguyen TL, Ozkan S, Razzaque MS, Prunier C, Thissen JP, Atfi A.

Dev Cell. 2018 Jun 18;45(6):712-725.e6. doi: 10.1016/j.devcel.2018.05.026.


Functional Characterization of a WWP1/Tiul1 Tumor-derived Mutant Reveals a Paradigm of Its Constitutive Activation in Human Cancer.

Courivaud T, Ferrand N, Elkhattouti A, Kumar S, Levy L, Ferrigno O, Atfi A, Prunier C.

J Biol Chem. 2015 Aug 21;290(34):21007-18. doi: 10.1074/jbc.M115.642314. Epub 2015 Jul 7.


TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.

Zhang MZ, Ferrigno O, Wang Z, Ohnishi M, Prunier C, Levy L, Razzaque M, Horne WC, Romero D, Tzivion G, Colland F, Baron R, Atfi A.

Cancer Cell. 2015 Apr 13;27(4):547-60. doi: 10.1016/j.ccell.2015.03.002.


Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis.

Prunier C, Zhang MZ, Kumar S, Levy L, Ferrigno O, Tzivion G, Atfi A.

Cell Rep. 2015 Feb 17;10(6):883-890. doi: 10.1016/j.celrep.2015.01.024. Epub 2015 Feb 12.


Identification of PHRF1 as a tumor suppressor that promotes the TGF-β cytostatic program through selective release of TGIF-driven PML inactivation.

Ettahar A, Ferrigno O, Zhang MZ, Ohnishi M, Ferrand N, Prunier C, Levy L, Bourgeade MF, Bieche I, Romero DG, Colland F, Atfi A.

Cell Rep. 2013 Aug 15;4(3):530-41. doi: 10.1016/j.celrep.2013.07.009. Epub 2013 Aug 1.


The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor.

Ferrand N, Atfi A, Prunier C.

Cancer Res. 2010 Nov 1;70(21):8457-66. doi: 10.1158/0008-5472.CAN-09-4088. Epub 2010 Oct 19.


A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicity.

Demange C, Ferrand N, Prunier C, Bourgeade MF, Atfi A.

Mol Cell. 2009 Dec 25;36(6):1073-85. doi: 10.1016/j.molcel.2009.12.009.


Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling.

Faresse N, Colland F, Ferrand N, Prunier C, Bourgeade MF, Atfi A.

EMBO J. 2008 Jul 9;27(13):1804-15. doi: 10.1038/emboj.2008.109. Epub 2008 May 29.


The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor.

Atfi A, Dumont E, Colland F, Bonnier D, L'helgoualc'h A, Prunier C, Ferrand N, Clément B, Wewer UM, Théret N.

J Cell Biol. 2007 Jul 16;178(2):201-8. Epub 2007 Jul 9.


A mechanism for mutational inactivation of the homeodomain protein TGIF in holoprosencephaly.

Ferrand N, Demange C, Prunier C, Seo SR, Atfi A.

FASEB J. 2007 Feb;21(2):488-96. Epub 2006 Dec 8.


Nuclear retention of the tumor suppressor cPML by the homeodomain protein TGIF restricts TGF-beta signaling.

Seo SR, Ferrand N, Faresse N, Prunier C, Abécassis L, Pessah M, Bourgeade MF, Atfi A.

Mol Cell. 2006 Aug;23(4):547-59.


The oncoprotein Ski acts as an antagonist of transforming growth factor-beta signaling by suppressing Smad2 phosphorylation.

Prunier C, Pessah M, Ferrand N, Seo SR, Howe P, Atfi A.

J Biol Chem. 2003 Jul 11;278(28):26249-57. Epub 2003 May 5.


Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R.

Dumont E, Lallemand F, Prunier C, Ferrand N, Guillouzo A, Clément B, Atfi A, Théret N.

J Biol Chem. 2003 Jul 4;278(27):24881-7. Epub 2003 Apr 16.


c-Jun associates with the oncoprotein Ski and suppresses Smad2 transcriptional activity.

Pessah M, Marais J, Prunier C, Ferrand N, Lallemand F, Mauviel A, Atfi A.

J Biol Chem. 2002 Aug 9;277(32):29094-100. Epub 2002 May 28.

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