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Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JS, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR; Alzheimer's Disease Genetics Consortium., Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA.

Alzheimers Dement. 2017 Feb 6. pii: S1552-5260(17)30003-1. doi: 10.1016/j.jalz.2016.12.012. [Epub ahead of print]


Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART).

Josephs KA, Murray ME, Tosakulwong N, Whitwell JL, Knopman DS, Machulda MM, Weigand SD, Boeve BF, Kantarci K, Petrucelli L, Lowe VJ, Jack CR Jr, Petersen RC, Parisi JE, Dickson DW.

Acta Neuropathol. 2017 Feb 3. doi: 10.1007/s00401-017-1681-2. [Epub ahead of print]


Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition.

Vemuri P, Lowe VJ, Knopman DS, Senjem ML, Kemp BJ, Schwarz CG, Przybelski SA, Machulda MM, Petersen RC, Jack CR Jr.

Alzheimers Dement (Amst). 2016 Dec 21;6:21-30. doi: 10.1016/j.dadm.2016.12.010.


Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype.

Krell-Roesch J, Vemuri P, Pink A, Roberts RO, Stokin GB, Mielke MM, Christianson TJ, Knopman DS, Petersen RC, Kremers WK, Geda YE.

JAMA Neurol. 2017 Jan 30. doi: 10.1001/jamaneurol.2016.3822. [Epub ahead of print]


Duration and Pathologic Correlates of Lewy Body Disease.

Graff-Radford J, Aakre J, Savica R, Boeve B, Kremers WK, Ferman TJ, Jones DT, Kantarci K, Knopman DS, Dickson DW, Kukull WA, Petersen RC.

JAMA Neurol. 2017 Jan 17. doi: 10.1001/jamaneurol.2016.4926. [Epub ahead of print]


ABCA7 loss-of-function variants, expression, and neurologic disease risk.

Allen M, Lincoln SJ, Corda M, Watzlawik JO, Carrasquillo MM, Reddy JS, Burgess JD, Nguyen T, Malphrus K, Petersen RC, Graff-Radford NR, Dickson DW, Ertekin-Taner N.

Neurol Genet. 2017 Jan 5;3(1):e126. doi: 10.1212/NXG.0000000000000126.


Excessive daytime sleepiness and fatigue may indicate accelerated brain aging in cognitively normal late middle-aged and older adults.

Carvalho DZ, St Louis EK, Boeve BF, Mielke MM, Przybelski SA, Knopman DS, Machulda MM, Roberts RO, Geda YE, Petersen RC, Jack CR Jr, Vemuri P.

Sleep Med. 2016 Nov 3. pii: S1389-9457(16)30225-8. doi: 10.1016/j.sleep.2016.08.023. [Epub ahead of print]


A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer's disease severity.

Schwarz CG, Gunter JL, Wiste HJ, Przybelski SA, Weigand SD, Ward CP, Senjem ML, Vemuri P, Murray ME, Dickson DW, Parisi JE, Kantarci K, Weiner MW, Petersen RC, Jack CR Jr; Alzheimer's Disease Neuroimaging Initiative..

Neuroimage Clin. 2016 May 30;11:802-812. doi: 10.1016/j.nicl.2016.05.017.


Brain tau deposition linked to systemic causes of death in normal elderly.

Josephs KA, Tosakulwong N, Weigand SD, Murray ME, Whitwell JL, Parisi JE, Dickson DW, Petersen RC.

Neurobiol Aging. 2017 Feb;50:163-166. doi: 10.1016/j.neurobiolaging.2016.11.011.


First PET Imaging Studies With 63Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease.

DeGrado TR, Kemp BJ, Pandey MK, Jiang H, Gunderson TM, Linscheid LR, Woodwick AR, McConnell DM, Fletcher JG, Johnson GB, Petersen RC, Knopman DS, Lowe VJ.

Mol Imaging. 2016 Dec 9;15. pii: 1536012116673793.


A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.

Carrasquillo MM, Allen M, Burgess JD, Wang X, Strickland SL, Aryal S, Siuda J, Kachadoorian ML, Medway C, Younkin CS, Nair A, Wang C, Chanana P, Serie D, Nguyen T, Lincoln S, Malphrus KG, Morgan K, Golde TE, Price ND, White CC, De Jager PL, Bennett DA, Asmann YW, Crook JE, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N.

Alzheimers Dement. 2016 Dec 8. pii: S1552-5260(16)33071-0. doi: 10.1016/j.jalz.2016.10.005. [Epub ahead of print]


Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.

Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, Bauer C, Checler F, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Albert M, Moghekar A, O'Brien R, Peskind ER, Malmanche N, Schellenberg GD, Dourlen P, Song OR, Cruchaga C, Amouyel P, Deprez B, Brodin P, Lambert JC; ADGC, Alzheimer’s Disease Neuroimaging Initiative..

Acta Neuropathol. 2016 Dec 8. [Epub ahead of print]


The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement.

Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR Jr, Jagust W, Morris JC, Petersen RC, Salazar J, Saykin AJ, Shaw LM, Toga AW, Trojanowski JQ; Alzheimer's Disease Neuroimaging Initiative..

Alzheimers Dement. 2016 Dec 5. pii: S1552-5260(16)33072-2. doi: 10.1016/j.jalz.2016.10.006. [Epub ahead of print] Review.


Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging.

Wennberg AM, Savica R, Hagen CE, Roberts RO, Knopman DS, Hollman JH, Vemuri P, Jack CR Jr, Petersen RC, Mielke MM.

J Am Geriatr Soc. 2016 Nov 21. doi: 10.1111/jgs.14670. [Epub ahead of print]


AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies.

Kantarci K, Lowe VJ, Boeve BF, Senjem ML, Tosakulwong N, Lesnick TG, Spychalla AJ, Gunter JL, Fields JA, Graff-Radford J, Ferman TJ, Jones DT, Murray ME, Knopman DS, Jack CR Jr, Petersen RC.

Ann Neurol. 2017 Jan;81(1):58-67. doi: 10.1002/ana.24825.


Clinicopathologic heterogeneity in FTDP-17 due to MAPT p.P301L mutation, including a patient with globular glial tauopathy.

Tacik P, Sanchez-Contreras M, DeTure M, Murray ME, Rademakers R, Ross OA, Wszolek ZK, Parisi JE, Knopman DS, Petersen RC, Dickson DW.

Neuropathol Appl Neurobiol. 2016 Nov 8. doi: 10.1111/nan.12367. [Epub ahead of print]


Hippocampal volumes predict risk of dementia with Lewy bodies in mild cognitive impairment.

Kantarci K, Lesnick T, Ferman TJ, Przybelski SA, Boeve BF, Smith GE, Kremers WK, Knopman DS, Jack CR Jr, Petersen RC.

Neurology. 2016 Nov 29;87(22):2317-2323.


Timing of Physical Activity, Apolipoprotein E ε4 Genotype, and Risk of Incident Mild Cognitive Impairment.

Krell-Roesch J, Pink A, Roberts RO, Stokin GB, Mielke MM, Spangehl KA, Bartley MM, Knopman DS, Christianson TJ, Petersen RC, Geda YE.

J Am Geriatr Soc. 2016 Dec;64(12):2479-2486. doi: 10.1111/jgs.14402.


Defining imaging biomarker cut points for brain aging and Alzheimer's disease.

Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Gunter JL, Senjem ML, Jones DT, Kantarci K, Machulda MM, Mielke MM, Roberts RO, Vemuri P, Reyes DA, Petersen RC.

Alzheimers Dement. 2016 Sep 30. pii: S1552-5260(16)32875-8. doi: 10.1016/j.jalz.2016.08.005. [Epub ahead of print]


[18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy.

Whitwell JL, Lowe VJ, Tosakulwong N, Weigand SD, Senjem ML, Schwarz CG, Spychalla AJ, Petersen RC, Jack CR Jr, Josephs KA.

Mov Disord. 2017 Jan;32(1):124-133. doi: 10.1002/mds.26834.

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