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Items: 1 to 20 of 108


Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development.

Tiklová K, Björklund ÅK, Lahti L, Fiorenzano A, Nolbrant S, Gillberg L, Volakakis N, Yokota C, Hilscher MM, Hauling T, Holmström F, Joodmardi E, Nilsson M, Parmar M, Perlmann T.

Nat Commun. 2019 Feb 4;10(1):581. doi: 10.1038/s41467-019-08453-1.


Author Correction: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.

Södersten E, Toskas K, Rraklli V, Tiklova K, Björklund ÅK, Ringnér M, Perlmann T, Holmberg J.

Nat Commun. 2018 Nov 2;9(1):4639. doi: 10.1038/s41467-018-07154-5.


A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons.

Södersten E, Toskas K, Rraklli V, Tiklova K, Björklund ÅK, Ringnér M, Perlmann T, Holmberg J.

Nat Commun. 2018 Mar 26;9(1):1226. doi: 10.1038/s41467-018-03538-9. Erratum in: Nat Commun. 2018 Nov 2;9(1):4639.


Alterations of p11 in brain tissue and peripheral blood leukocytes in Parkinson's disease.

Green H, Zhang X, Tiklova K, Volakakis N, Brodin L, Berg L, Greengard P, Perlmann T, Svenningsson P.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2735-2740. doi: 10.1073/pnas.1621218114. Epub 2017 Jan 30.


Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

Kee N, Volakakis N, Kirkeby A, Dahl L, Storvall H, Nolbrant S, Lahti L, Björklund ÅK, Gillberg L, Joodmardi E, Sandberg R, Parmar M, Perlmann T.

Cell Stem Cell. 2017 Jan 5;20(1):29-40. doi: 10.1016/j.stem.2016.10.003. Epub 2016 Oct 27.


Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

Kirkeby A, Nolbrant S, Tiklova K, Heuer A, Kee N, Cardoso T, Ottosson DR, Lelos MJ, Rifes P, Dunnett SB, Grealish S, Perlmann T, Parmar M.

Cell Stem Cell. 2017 Jan 5;20(1):135-148. doi: 10.1016/j.stem.2016.09.004. Epub 2016 Oct 27.


The stem cell niche finds its true north.

Kirkeby A, Perlmann T, Pereira CF.

Development. 2016 Aug 15;143(16):2877-81. doi: 10.1242/dev.140095. Review.


Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.

Doucet-Beaupré H, Gilbert C, Profes MS, Chabrat A, Pacelli C, Giguère N, Rioux V, Charest J, Deng Q, Laguna A, Ericson J, Perlmann T, Ang SL, Cicchetti F, Parent M, Trudeau LE, Lévesque M.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4387-96. doi: 10.1073/pnas.1520387113. Epub 2016 Jul 12.


The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2.

Gross S, Garofalo DC, Balderes DA, Mastracci TL, Dias JM, Perlmann T, Ericson J, Sussel L.

Development. 2016 Jul 15;143(14):2616-28. doi: 10.1242/dev.130682. Epub 2016 Jun 10.


Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors.

Hedlund E, Belnoue L, Theofilopoulos S, Salto C, Bye C, Parish C, Deng Q, Kadkhodaei B, Ericson J, Arenas E, Perlmann T, Simon A.

Sci Rep. 2016 Jun 1;6:26448. doi: 10.1038/srep26448.


Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression.

Volakakis N, Tiklova K, Decressac M, Papathanou M, Mattsson B, Gillberg L, Nobre A, Björklund A, Perlmann T.

J Neurosci. 2015 Oct 21;35(42):14370-85. doi: 10.1523/JNEUROSCI.1155-15.2015.


Modulation by Trace Amine-Associated Receptor 1 of Experimental Parkinsonism, L-DOPA Responsivity, and Glutamatergic Neurotransmission.

Alvarsson A, Zhang X, Stan TL, Schintu N, Kadkhodaei B, Millan MJ, Perlmann T, Svenningsson P.

J Neurosci. 2015 Oct 14;35(41):14057-69. doi: 10.1523/JNEUROSCI.1312-15.2015.


Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.

Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gómez-Galán M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T.

Nat Neurosci. 2015 Jun;18(6):826-35. doi: 10.1038/nn.4004. Epub 2015 Apr 27.


Function of transcription factors at DNA lesions in DNA repair.

Malewicz M, Perlmann T.

Exp Cell Res. 2014 Nov 15;329(1):94-100. doi: 10.1016/j.yexcr.2014.08.032. Epub 2014 Aug 28. Review.


Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons.

Panman L, Papathanou M, Laguna A, Oosterveen T, Volakakis N, Acampora D, Kurtsdotter I, Yoshitake T, Kehr J, Joodmardi E, Muhr J, Simeone A, Ericson J, Perlmann T.

Cell Rep. 2014 Aug 21;8(4):1018-25. doi: 10.1016/j.celrep.2014.07.016. Epub 2014 Aug 7.


Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells.

Mong J, Panman L, Alekseenko Z, Kee N, Stanton LW, Ericson J, Perlmann T.

Stem Cells. 2014 Mar;32(3):609-22. doi: 10.1002/stem.1585.


NURR1 in Parkinson disease--from pathogenesis to therapeutic potential.

Decressac M, Volakakis N, Björklund A, Perlmann T.

Nat Rev Neurol. 2013 Nov;9(11):629-36. doi: 10.1038/nrneurol.2013.209. Epub 2013 Oct 15. Review.


Detailed expression analysis of regulatory genes in the early developing human neural tube.

Marklund U, Alekseenko Z, Andersson E, Falci S, Westgren M, Perlmann T, Graham A, Sundström E, Ericson J.

Stem Cells Dev. 2014 Jan 1;23(1):5-15. doi: 10.1089/scd.2013.0309. Epub 2013 Oct 8.


Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons.

Kadkhodaei B, Alvarsson A, Schintu N, Ramsköld D, Volakakis N, Joodmardi E, Yoshitake T, Kehr J, Decressac M, Björklund A, Sandberg R, Svenningsson P, Perlmann T.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2360-5. doi: 10.1073/pnas.1221077110. Epub 2013 Jan 22.


α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.

Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Björklund A.

Sci Transl Med. 2012 Dec 5;4(163):163ra156. doi: 10.1126/scitranslmed.3004676. Erratum in: Sci Transl Med. 2016 Apr 20;8(335):335er4.

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