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1989 4
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1991 10
1992 3
1993 2
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1998 6
1999 3
2000 4
2002 3
2003 4
2004 6
2005 4
2006 10
2007 5
2008 9
2009 9
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2012 5
2013 17
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2015 9
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249 results

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Page 1
Meldonium (Mildronate): A Performance-Enhancing Drug?
Greenblatt HK, Greenblatt DJ. Greenblatt HK, et al. Clin Pharmacol Drug Dev. 2016 May;5(3):167-9. doi: 10.1002/cpdd.264. Epub 2016 Apr 29. Clin Pharmacol Drug Dev. 2016. PMID: 27128409 No abstract available.
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
Dambrova M, Makrecka-Kuka M, Vilskersts R, Makarova E, Kuka J, Liepinsh E. Dambrova M, et al. Pharmacol Res. 2016 Nov;113(Pt B):771-780. doi: 10.1016/j.phrs.2016.01.019. Epub 2016 Feb 2. Pharmacol Res. 2016. PMID: 26850121 Review.
Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, which mechanism of action is based on the regulation of energy metabolism pathways through l-carnitine lowering effect. l-Carnitine biosynthesis
Meldonium (mildronate; 3-(2,2,2-trimethylhydrazinium)propionate; THP; MET-88) is a clinically used cardioprotective drug, whic
Story behind meldonium-from pharmacology to performance enhancement: a narrative review.
Schobersberger W, Dünnwald T, Gmeiner G, Blank C. Schobersberger W, et al. Br J Sports Med. 2017 Jan;51(1):22-25. doi: 10.1136/bjsports-2016-096357. Epub 2016 Jul 27. Br J Sports Med. 2017. PMID: 27465696 Review.
Recent reports from the World Anti-Doping Agency (WADA) indicate an alarming prevalence in the use of meldonium among elite athletes. Therefore, in January 2016, meldonium was added to WADA's prohibited list after being monitored since 2015. ...Among athletes, me
Recent reports from the World Anti-Doping Agency (WADA) indicate an alarming prevalence in the use of meldonium among elite athletes. …
Meldonium (Mildronate): Primum nn nocere.
Jargin SV. Jargin SV. Pharmacol Res. 2016 Dec;114:294. doi: 10.1016/j.phrs.2016.10.004. Epub 2016 Oct 8. Pharmacol Res. 2016. PMID: 27725310 No abstract available.
Mildronate: an antiischemic drug for neurological indications.
Sjakste N, Gutcaits A, Kalvinsh I. Sjakste N, et al. CNS Drug Rev. 2005 Summer;11(2):151-68. doi: 10.1111/j.1527-3458.2005.tb00267.x. CNS Drug Rev. 2005. PMID: 16007237 Free PMC article. Review.
Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the Latvian Institute of Organic Synthesis. ...Mildronate is efficient in the treatment of heart ischemia and its consequences. ...
Mildronate (3-(2,2,2-trimethylhydrazinium)propionate; MET-88; meldonium, quaterine) is an antiischemic drug developed at the L
Urinary excretion studies of meldonium after multidose parenteral application.
Forsdahl G, Jančić-Stojanović B, Anđelković M, Dikić N, Geisendorfer T, Jeitler V, Gmeiner G. Forsdahl G, et al. J Pharm Biomed Anal. 2018 Nov 30;161:289-295. doi: 10.1016/j.jpba.2018.08.053. Epub 2018 Aug 28. J Pharm Biomed Anal. 2018. PMID: 30189410
Meldonium is a drug exhibiting cardioprotective and anti-ischemic effects. ...Since then, a high number of adverse analytical findings reported on meldonium has questioned meldonium`s detection time in urine. Hence, the objective of the current study was to c
Meldonium is a drug exhibiting cardioprotective and anti-ischemic effects. ...Since then, a high number of adverse analytical finding
The effects of meldonium on the acute ischemia/reperfusion liver injury in rats.
Đurašević S, Stojković M, Sopta J, Pavlović S, Borković-Mitić S, Ivanović A, Jasnić N, Tosti T, Đurović S, Đorđević J, Todorović Z. Đurašević S, et al. Sci Rep. 2021 Jan 14;11(1):1305. doi: 10.1038/s41598-020-80011-y. Sci Rep. 2021. PMID: 33446709 Free PMC article.
Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar strain male rats. ...Based on our results, it can be concluded that meldonium represent a protective agent against I/R-induced liver in …
Thus, we investigated the effects of a 4-week meldonium pre-treatment (300 mg/kg b.m./day) on the acute I/R liver injury in Wistar st …
The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats.
Đurašević S, Ružičić A, Lakić I, Tosti T, Đurović S, Glumac S, Pavlović S, Borković-Mitić S, Grigorov I, Stanković S, Jasnić N, Đorđević J, Todorović Z. Đurašević S, et al. Int J Mol Sci. 2021 Sep 8;22(18):9698. doi: 10.3390/ijms22189698. Int J Mol Sci. 2021. PMID: 34575863 Free PMC article.
Surprisingly, under septic conditions, meldonium increased animal mortality rate compared with the meldonium non-treated group. However, analysis of the tissue oxidative status did not provide support for the detrimental effects of meldonium, nor did the anal …
Surprisingly, under septic conditions, meldonium increased animal mortality rate compared with the meldonium non-treated group …
Mildronate: cardioprotective action through carnitine-lowering effect.
Dambrova M, Liepinsh E, Kalvinsh I. Dambrova M, et al. Trends Cardiovasc Med. 2002 Aug;12(6):275-9. doi: 10.1016/s1050-1738(02)00175-5. Trends Cardiovasc Med. 2002. PMID: 12242052 Review.
Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial energy metabolism. ...Because mildronate treatment prepares cellular metabolism and membrane structures to survive ischemic stress c
Mildronate [3-(2,2,2-trimethylhydrazinium)propionate dihydrate] ameliorates cardiac function during ischemia by modulating myocardial
Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent.
Porter C, Constantin-Teodosiu D, Constantin D, Leighton B, Poucher SM, Greenhaff PL. Porter C, et al. J Physiol. 2017 Sep 1;595(17):5765-5780. doi: 10.1113/JP274415. Epub 2017 Jul 16. J Physiol. 2017. PMID: 28605113 Free PMC article.
KEY POINTS: Meldonium inhibits endogenous carnitine synthesis and tissue uptake, and accelerates urinary carnitine excretion, although the impact of meldonium-mediated muscle carnitine depletion on whole-body fuel selection, and muscle fuel metabolism and its molecu …
KEY POINTS: Meldonium inhibits endogenous carnitine synthesis and tissue uptake, and accelerates urinary carnitine excretion, althoug …
249 results