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A versatile flow-based assay for immunocyte-mediated cytotoxicity.

Rabinovich PM, Zhang J, Kerr SR, Cheng BH, Komarovskaya M, Bersenev A, Hurwitz ME, Krause DS, Weissman SM, Katz SG.

J Immunol Methods. 2019 Nov;474:112668. doi: 10.1016/j.jim.2019.112668. Epub 2019 Sep 13.


Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy.

Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M 3rd, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS.

PLoS Biol. 2019 Sep 12;17(9):e3000421. doi: 10.1371/journal.pbio.3000421. eCollection 2019 Sep.


Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice.

Xavier-Ferrucio J, Scanlon V, Li X, Zhang PX, Lozovatsky L, Ayala-Lopez N, Tebaldi T, Halene S, Cao C, Fleming MD, Finberg KE, Krause DS.

Blood. 2019 Oct 31;134(18):1547-1557. doi: 10.1182/blood.2019002039.


Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit.

He L, Cohen EB, Edwards APB, Xavier-Ferrucio J, Bugge K, Federman RS, Absher D, Myers RM, Kragelund BB, Krause DS, DiMaio D.

iScience. 2019 Jul 26;17:167-181. doi: 10.1016/j.isci.2019.06.027. Epub 2019 Jun 21.


IFN-γ binds TPO to inhibit hematopoiesis.

Krause DS.

Blood. 2019 May 9;133(19):2004-2005. doi: 10.1182/blood-2019-03-900977. No abstract available.


MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation.

Hu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S.

Nat Commun. 2019 Apr 12;10(1):1695. doi: 10.1038/s41467-019-09636-6.


Epithelial (E)-Cadherin is a Novel Mediator of Platelet Aggregation and Clot Stability.

Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS.

Thromb Haemost. 2019 May;119(5):744-757. doi: 10.1055/s-0039-1679908. Epub 2019 Mar 12.


Promoters to Study Vascular Smooth Muscle.

Chakraborty R, Saddouk FZ, Carrao AC, Krause DS, Greif DM, Martin KA.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):603-612. doi: 10.1161/ATVBAHA.119.312449.


Single-cell microRNA-mRNA co-sequencing reveals non-genetic heterogeneity and mechanisms of microRNA regulation.

Wang N, Zheng J, Chen Z, Liu Y, Dura B, Kwak M, Xavier-Ferrucio J, Lu YC, Zhang M, Roden C, Cheng J, Krause DS, Ding Y, Fan R, Lu J.

Nat Commun. 2019 Jan 9;10(1):95. doi: 10.1038/s41467-018-07981-6.


The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification.

Lu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS.

Cell Rep. 2018 Nov 20;25(8):2083-2093.e4. doi: 10.1016/j.celrep.2018.10.084. Erratum in: Cell Rep. 2018 Dec 11;25(11):3229.


MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis.

Rahman NT, Schulz VP, Wang L, Gallagher PG, Denisenko O, Gualdrini F, Esnault C, Krause DS.

Blood Adv. 2018 Oct 23;2(20):2691-2703. doi: 10.1182/bloodadvances.2018019448.


Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies.

Xavier-Ferrucio J, Krause DS.

Stem Cells. 2018 Aug;36(8):1138-1145. doi: 10.1002/stem.2834. Epub 2018 May 2. Review.


Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.

Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang PX, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L882-L892. doi: 10.1152/ajplung.00418.2017. Epub 2018 Jan 18.


Hematopoietic defects in response to reduced Arhgap21.

Xavier-Ferrucio J, Ricon L, Vieira K, Longhini AL, Lazarini M, Bigarella CL, Franchi G Jr, Krause DS, Saad STO.

Stem Cell Res. 2018 Jan;26:17-27. doi: 10.1016/j.scr.2017.11.014. Epub 2017 Nov 23.


Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages.

Di Pietro C, Zhang PX, O'Rourke TK, Murray TS, Wang L, Britto CJ, Koff JL, Krause DS, Egan ME, Bruscia EM.

Sci Rep. 2017 Sep 7;7(1):10882. doi: 10.1038/s41598-017-11012-7.


SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume.

Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS.

PLoS One. 2017 May 23;12(5):e0178095. doi: 10.1371/journal.pone.0178095. eCollection 2017.


Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.

de Rooij JD, Branstetter C, Ma J, Li Y, Walsh MP, Cheng J, Obulkasim A, Dang J, Easton J, Verboon LJ, Mulder HL, Zimmermann M, Koss C, Gupta P, Edmonson M, Rusch M, Lim JY, Reinhardt K, Pigazzi M, Song G, Yeoh AE, Shih LY, Liang DC, Halene S, Krause DS, Zhang J, Downing JR, Locatelli F, Reinhardt D, van den Heuvel-Eibrink MM, Zwaan CM, Fornerod M, Gruber TA.

Nat Genet. 2017 Mar;49(3):451-456. doi: 10.1038/ng.3772. Epub 2017 Jan 23.


In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.

Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM.

Nat Commun. 2016 Oct 26;7:13304. doi: 10.1038/ncomms13304.


ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction.

Bartulos O, Zhuang ZW, Huang Y, Mikush N, Suh C, Bregasi A, Wang L, Chang W, Krause DS, Young LH, Pober JS, Qyang Y.

JCI Insight. 2016 Jul 7;1(10). pii: 80920. doi: 10.1172/jci.insight.80920.


Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.

Zou S, Teixeira AM, Yin M, Xiang Y, Xavier-Ferrucio J, Zhang PX, Hwa J, Min W, Krause DS.

Thromb Haemost. 2016 Aug 30;116(3):506-16. doi: 10.1160/TH15-11-0848. Epub 2016 Jun 23.

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