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Items: 1 to 20 of 63


Biosynthesis, structure, and folding of the insulin precursor protein.

Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P.

Diabetes Obes Metab. 2018 Sep;20 Suppl 2:28-50. doi: 10.1111/dom.13378. Review.


ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.

Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M.

Cell. 2018 Aug 31. pii: S0092-8674(18)31036-5. doi: 10.1016/j.cell.2018.08.020. [Epub ahead of print]


IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs.

Wang JM, Qiu Y, Yang Z, Kim H, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yang L, Zhang K.

Sci Signal. 2018 May 15;11(530). pii: eaao4617. doi: 10.1126/scisignal.aao4617.


High-content screen for modifiers of Niemann-Pick type C disease in patient cells.

Pugach EK, Feltes M, Kaufman RJ, Ory DS, Bang AG.

Hum Mol Genet. 2018 Jun 15;27(12):2101-2112. doi: 10.1093/hmg/ddy117.


HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency.

Zhang S, Macias-Garcia A, Velazquez J, Paltrinieri E, Kaufman RJ, Chen JJ.

Blood. 2018 Jan 25;131(4):450-461. doi: 10.1182/blood-2017-08-799908. Epub 2017 Nov 3.


Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response.

Chandrahas VK, Han J, Kaufman RJ.

Curr Top Microbiol Immunol. 2018;414:103-130. doi: 10.1007/82_2017_41. Review.


Physiological/pathological ramifications of transcription factors in the unfolded protein response.

Han J, Kaufman RJ.

Genes Dev. 2017 Jul 15;31(14):1417-1438. doi: 10.1101/gad.297374.117. Review.


eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet.

Choi WG, Han J, Kim JH, Kim MJ, Park JW, Song B, Cha HJ, Choi HS, Chung HT, Lee IK, Park TS, Hatzoglou M, Choi HS, Yoo HJ, Kaufman RJ, Back SH.

Nutr Metab (Lond). 2017 Aug 1;14:48. doi: 10.1186/s12986-017-0202-6. eCollection 2017.


Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response.

Poothong J, Tirasophon W, Kaufman RJ.

Biosci Rep. 2017 Mar 2;37(2). pii: BSR20160574. doi: 10.1042/BSR20160574. Print 2017 Apr 30.


Achromatopsia mutations target sequential steps of ATF6 activation.

Chiang WC, Chan P, Wissinger B, Vincent A, Skorczyk-Werner A, Krawczyński MR, Kaufman RJ, Tsang SH, Héon E, Kohl S, Lin JH.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):400-405. doi: 10.1073/pnas.1606387114. Epub 2016 Dec 27.


Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia.

Yao T, Deng Z, Gao Y, Sun J, Kong X, Huang Y, He Z, Xu Y, Chang Y, Yu KJ, Findley BG, Berglund ED, Wang RT, Guo H, Chen H, Li X, Kaufman RJ, Yan J, Liu T, Williams KW.

Diabetes. 2017 Mar;66(3):663-673. doi: 10.2337/db16-0533. Epub 2016 Dec 27.


IRE1α nucleotide sequence cleavage specificity in the unfolded protein response.

Poothong J, Sopha P, Kaufman RJ, Tirasophon W.

FEBS Lett. 2017 Jan;591(2):406-414. doi: 10.1002/1873-3468.12546. Epub 2017 Jan 17. Erratum in: FEBS Lett. 2018 Aug;592(15):2669.


ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.

Jin JK, Blackwood EA, Azizi K, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC.

Circ Res. 2017 Mar 3;120(5):862-875. doi: 10.1161/CIRCRESAHA.116.310266. Epub 2016 Dec 8.


Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, Bourdel G, Popovic N, Rezende FA, Kaufman RJ, Mallette FA, Sapieha P.

Sci Transl Med. 2016 Oct 26;8(362):362ra144.


Read-Split-Run: an improved bioinformatics pipeline for identification of genome-wide non-canonical spliced regions using RNA-Seq data.

Bai Y, Kinne J, Donham B, Jiang F, Ding L, Hassler JR, Kaufman RJ.

BMC Genomics. 2016 Aug 22;17 Suppl 7:503. doi: 10.1186/s12864-016-2896-7.


The unfolded protein response in immunity and inflammation.

Grootjans J, Kaser A, Kaufman RJ, Blumberg RS.

Nat Rev Immunol. 2016 Aug;16(8):469-84. doi: 10.1038/nri.2016.62. Epub 2016 Jun 27. Review.


Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.

Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH 3rd, Ferguson TA, Chen DF, Kaufman RJ, Hu Y.

J Neurosci. 2016 May 25;36(21):5891-903. doi: 10.1523/JNEUROSCI.3709-15.2016.


The role of ER stress in lipid metabolism and lipotoxicity.

Han J, Kaufman RJ.

J Lipid Res. 2016 Aug;57(8):1329-38. doi: 10.1194/jlr.R067595. Epub 2016 May 4. Review.


The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.

Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B.

Nature. 2016 Mar 24;531(7595):523-527. doi: 10.1038/nature17186. Epub 2016 Mar 16.


Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations.

Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink DM, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, Ryoo HD, Steller H, Urano F, Chevet E, Kroemer G, Ciechanover A, Calabrese EJ, Kaufman RJ, Hetz C.

Brain Res. 2016 Oct 1;1648(Pt B):603-616. doi: 10.1016/j.brainres.2016.02.033. Epub 2016 Mar 2. Review.

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