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Items: 20


Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age.

Syal C, Seegobin M, Sarma SN, Gouveia A, Hsu K, Niibori Y, He L, Wondisford FE, Frankland PW, Wang J.

Sci Rep. 2018 Sep 10;8(1):13489. doi: 10.1038/s41598-018-31657-2.


Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis.

Wu Y, Pan Q, Yan H, Zhang K, Guo X, Xu Z, Yang W, Qi Y, Guo CA, Hornsby C, Zhang L, Zhou A, Li L, Chen Y, Zhang W, Sun Y, Zheng H, Wondisford F, He L, Guo S.

Diabetes. 2018 Nov;67(11):2167-2182. doi: 10.2337/db18-0674. Epub 2018 Sep 10.


PDK4 Deficiency Suppresses Hepatic Glucagon Signaling by Decreasing cAMP Levels.

Park BY, Jeon JH, Go Y, Ham HJ, Kim JE, Yoo EK, Kwon WH, Jeoung NH, Jeon YH, Koo SH, Kim BG, He L, Park KG, Harris RA, Lee IK.

Diabetes. 2018 Oct;67(10):2054-2068. doi: 10.2337/db17-1529. Epub 2018 Jul 31.


The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery.

Gouveia A, Seegobin M, Kannangara TS, He L, Wondisford F, Comin CH, Costa LDF, Béïque JC, Lagace DC, Lacoste B, Wang J.

Stem Cell Reports. 2017 Dec 12;9(6):1735-1744. doi: 10.1016/j.stemcr.2017.10.021. Epub 2017 Nov 22.


IRS posttranslational modifications in regulating insulin signaling.

Peng J, He L.

J Mol Endocrinol. 2018 Jan;60(1):R1-R8. doi: 10.1530/JME-17-0151. Epub 2017 Nov 1. Review.


Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity.

Cao J, Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L.

Nat Commun. 2017 Jul 25;8(1):131. doi: 10.1038/s41467-017-00163-w.


Controlled Heat Stress Promotes Myofibrillogenesis during Myogenesis.

Guo Q, Miller D, An H, Wang H, Lopez J, Lough D, He L, Kumar A.

PLoS One. 2016 Nov 8;11(11):e0166294. doi: 10.1371/journal.pone.0166294. eCollection 2016.


The aPKC-CBP Pathway Regulates Adult Hippocampal Neurogenesis in an Age-Dependent Manner.

Gouveia A, Hsu K, Niibori Y, Seegobin M, Cancino GI, He L, Wondisford FE, Bennett S, Lagace D, Frankland PW, Wang J.

Stem Cell Reports. 2016 Oct 11;7(4):719-734. doi: 10.1016/j.stemcr.2016.08.007. Epub 2016 Sep 8.


Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production.

He L, Chang E, Peng J, An H, McMillin SM, Radovick S, Stratakis CA, Wondisford FE.

J Biol Chem. 2016 May 13;291(20):10562-70. doi: 10.1074/jbc.M116.719666. Epub 2016 Mar 21.


Current understanding of metformin effect on the control of hyperglycemia in diabetes.

An H, He L.

J Endocrinol. 2016 Mar;228(3):R97-106. doi: 10.1530/JOE-15-0447. Epub 2016 Jan 7. Review.


Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation.

Fatt M, Hsu K, He L, Wondisford F, Miller FD, Kaplan DR, Wang J.

Stem Cell Reports. 2015 Dec 8;5(6):988-995. doi: 10.1016/j.stemcr.2015.10.014. Epub 2015 Nov 19.


Metformin action: concentrations matter.

He L, Wondisford FE.

Cell Metab. 2015 Feb 3;21(2):159-162. doi: 10.1016/j.cmet.2015.01.003.


Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex.

Meng S, Cao J, He Q, Xiong L, Chang E, Radovick S, Wondisford FE, He L.

J Biol Chem. 2015 Feb 6;290(6):3793-802. doi: 10.1074/jbc.M114.604421. Epub 2014 Dec 23.


A small amount of dietary carbohydrate can promote the HFD-induced insulin resistance to a maximal level.

Mei S, Yang X, Guo H, Gu H, Zha L, Cai J, Li X, Liu Z, Bennett BJ, He L, Cao W.

PLoS One. 2014 Jul 23;9(7):e100875. doi: 10.1371/journal.pone.0100875. eCollection 2014.


Potential biomarker of metformin action.

He L, Meng S, Germain-Lee EL, Radovick S, Wondisford FE.

J Endocrinol. 2014 Jun;221(3):363-9. doi: 10.1530/JOE-14-0084. Epub 2014 Mar 17.


Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage.

He L, Cao J, Meng S, Ma A, Radovick S, Wondisford FE.

Mol Endocrinol. 2013 Aug;27(8):1322-32. doi: 10.1210/me.2012-1413. Epub 2013 Jun 14.


Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.

Romero CJ, Pine-Twaddell E, Sima DI, Miller RS, He L, Wondisford F, Radovick S.

Mol Cell Biol. 2012 Nov;32(21):4258-69. doi: 10.1128/MCB.00171-12. Epub 2012 Aug 13.


Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis.

He L, Naik K, Meng S, Cao J, Sidhaye AR, Ma A, Radovick S, Wondisford FE.

J Biol Chem. 2012 Sep 14;287(38):32069-77. doi: 10.1074/jbc.M112.385864. Epub 2012 Jul 19.


CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.

Miller RS, Wolfe A, He L, Radovick S, Wondisford FE.

Mol Cell Biol. 2012 Jul;32(13):2349-58. doi: 10.1128/MCB.00394-12. Epub 2012 Apr 16.


Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.

He L, Sabet A, Djedjos S, Miller R, Sun X, Hussain MA, Radovick S, Wondisford FE.

Cell. 2009 May 15;137(4):635-46. doi: 10.1016/j.cell.2009.03.016.

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