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Items: 1 to 20 of 36


Surfactant Protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.

Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang PX, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 18. doi: 10.1152/ajplung.00418.2017. [Epub ahead of print]


Characterisation of asthma subgroups associated with circulating YKL-40 levels.

Gomez JL, Yan X, Holm CT, Grant N, Liu Q, Cohn L, Nezgovorova V, Meyers DA, Bleecker ER, Crisafi GM, Jarjour NN, Rogers L, Reibman J, Chupp GL; SARP Investigators.

Eur Respir J. 2017 Oct 12;50(4). pii: 1700800. doi: 10.1183/13993003.00800-2017. Print 2017 Oct.


Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies.

Chupp G, Laviolette M, Cohn L, McEvoy C, Bansal S, Shifren A, Khatri S, Grubb GM, McMullen E, Strauven R, Kline JN; Other members of the PAS2 Study Group.

Eur Respir J. 2017 Aug 31;50(2). pii: 1700017. doi: 10.1183/13993003.00017-2017. Print 2017 Aug. Erratum in: Eur Respir J. 2017 Oct 12;50(4):.


A novel pathway-based distance score enhances assessment of disease heterogeneity in gene expression.

Yan X, Liang A, Gomez J, Cohn L, Zhao H, Chupp GL.

BMC Bioinformatics. 2017 Jun 20;18(1):309. doi: 10.1186/s12859-017-1727-4.


Sputum Gene Expression of IL-13 Receptor α2 Chain Correlates with Airflow Obstruction and Helper T-Cell Type 2 Inflammation in Asthma.

Nezgovorova V, Liu Q, Hu B, Villalobos JL, Yan X, Niu N, Holm C, Grant NP, Marone S, Ravage-Mass L, Lee CG, Elias JA, Cohn L, Chupp GL.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S96-7. doi: 10.1513/AnnalsATS.201509-611MG.


Noninvasive Analysis of the Sputum Transcriptome Discriminates Clinical Phenotypes of Asthma.

Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL.

Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S104-5. doi: 10.1513/AnnalsATS.201510-681MG.


Noninvasive analysis of the sputum transcriptome discriminates clinical phenotypes of asthma.

Yan X, Chu JH, Gomez J, Koenigs M, Holm C, He X, Perez MF, Zhao H, Mane S, Martinez FD, Ober C, Nicolae DL, Barnes KC, London SJ, Gilliland F, Weiss ST, Raby BA, Cohn L, Chupp GL.

Am J Respir Crit Care Med. 2015 May 15;191(10):1116-25. doi: 10.1164/rccm.201408-1440OC.


Genetic variation in chitinase 3-like 1 (CHI3L1) contributes to asthma severity and airway expression of YKL-40.

Gomez JL, Crisafi GM, Holm CT, Meyers DA, Hawkins GA, Bleecker ER, Jarjour N; Severe Asthma Research Program (SARP) Investigators, Cohn L, Chupp GL.

J Allergy Clin Immunol. 2015 Jul;136(1):51-58.e10. doi: 10.1016/j.jaci.2014.11.027. Epub 2015 Jan 13.


Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease.

Britto CJ, Cohn L.

Am J Respir Cell Mol Biol. 2015 May;52(5):525-34. doi: 10.1165/rcmb.2014-0297RT. Review.


Update in asthma 2013.

Cohn L, Woodruff PG.

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1487-93. doi: 10.1164/rccm.201403-0498UP. Review. No abstract available.


VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis.

Takyar S, Vasavada H, Zhang JG, Ahangari F, Niu N, Liu Q, Lee CG, Cohn L, Elias JA.

J Exp Med. 2013 Sep 23;210(10):1993-2010. doi: 10.1084/jem.20121200. Epub 2013 Sep 16.


Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity.

Britto CJ, Liu Q, Curran DR, Patham B, Dela Cruz CS, Cohn L.

Am J Respir Cell Mol Biol. 2013 Jun;48(6):717-24. doi: 10.1165/rcmb.2012-0072OC.


IFN-γ acts on the airway epithelium to inhibit local and systemic pathology in allergic airway disease.

Mitchell C, Provost K, Niu N, Homer R, Cohn L.

J Immunol. 2011 Oct 1;187(7):3815-20. doi: 10.4049/jimmunol.1100436. Epub 2011 Aug 26.


Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.

Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC.

J Exp Med. 2010 Nov 22;207(12):2595-607. doi: 10.1084/jem.20100786. Epub 2010 Oct 25.


Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.

Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D.

J Biol Chem. 2009 Oct 16;284(42):28599-606. doi: 10.1074/jbc.M109.047282. Epub 2009 Aug 27.


Cutting edge: Limiting MHC class II expression to dendritic cells alters the ability to develop Th2- dependent allergic airway inflammation.

Niu N, Laufer T, Homer RJ, Cohn L.

J Immunol. 2009 Aug 1;183(3):1523-7. doi: 10.4049/jimmunol.0901349. Epub 2009 Jul 13.


Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.

Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA.

Clin Immunol. 2009 Sep;132(3):371-84. doi: 10.1016/j.clim.2009.05.016. Epub 2009 Jun 24.


Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease.

Curran DR, Cohn L.

Am J Respir Cell Mol Biol. 2010 Mar;42(3):268-75. doi: 10.1165/rcmb.2009-0151TR. Epub 2009 Jun 11. Review.


A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma.

Caceres AI, Brackmann M, Elia MD, Bessac BF, del Camino D, D'Amours M, Witek JS, Fanger CM, Chong JA, Hayward NJ, Homer RJ, Cohn L, Huang X, Moran MM, Jordt SE.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9099-104. doi: 10.1073/pnas.0900591106. Epub 2009 May 19.


Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.

Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA.

J Exp Med. 2009 May 11;206(5):1149-66. doi: 10.1084/jem.20081271. Epub 2009 May 4.

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