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1993 2
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1999 6
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Page 1
Plant Adaptogens-History and Future Perspectives.
Todorova V, Ivanov K, Delattre C, Nalbantova V, Karcheva-Bahchevanska D, Ivanova S. Todorova V, et al. Nutrients. 2021 Aug 20;13(8):2861. doi: 10.3390/nu13082861. Nutrients. 2021. PMID: 34445021 Free PMC article.
Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to enhance the body's stability against physical loads without increasing oxygen consumption. ...
Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to en …
The pharmacology of actoprotectors: practical application for improvement of mental and physical performance.
Oliynyk S, Oh S. Oliynyk S, et al. Biomol Ther (Seoul). 2012 Sep;20(5):446-56. doi: 10.4062/biomolther.2012.20.5.446. Biomol Ther (Seoul). 2012. PMID: 24009833 Free PMC article. Review.
A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is provided. Some other synthesized compounds, and even natural ones such as ginseng, also are regarded as potential actoprotectors, and these …
A brief summary of the clinico-pharmacological characteristics of the main representatives of this class (bemitil and bromantane) is …
The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats.
Mikhaylova M, Vakhitova JV, Yamidanov RS, Salimgareeva MKh, Seredenin SB, Behnisch T. Mikhaylova M, et al. Neuropharmacology. 2007 Oct;53(5):601-8. doi: 10.1016/j.neuropharm.2007.07.001. Epub 2007 Jul 17. Neuropharmacology. 2007. PMID: 17854844
We found that ladasten differentially regulates tyrosine hydroxylase mRNA and protein as well as dopamine and L-DOPA content. We then investigated the effects of ladasten on activity-dependent hippocampal synaptic plasticity in vitro and found that application of 10 …
We found that ladasten differentially regulates tyrosine hydroxylase mRNA and protein as well as dopamine and L-DOPA content. We then …
Toxic effect of single treatment with bromantane on neurological status of experimental animals.
Iezhitsa IN, Spasov AA, Bugaeva LI, Morozov IS. Iezhitsa IN, et al. Bull Exp Biol Med. 2002 Apr;133(4):380-3. doi: 10.1023/a:1016206306875. Bull Exp Biol Med. 2002. PMID: 12124651
In doses above 5 g/kg bromantane slightly increased respiration rate and depth (Kussmaul-like respiration). In some animals bromantane in high doses induced regurgitation, diarrhea, and polyuria. ...
In doses above 5 g/kg bromantane slightly increased respiration rate and depth (Kussmaul-like respiration). In some animals broman
Effect of ladasten on the content of cytokine markers of inflammation and behavior of mice with experimental depression-like syndrome.
Tallerova AV, Kovalenko LP, Durnev AD, Seredenin SB. Tallerova AV, et al. Bull Exp Biol Med. 2011 Nov;152(1):58-60. doi: 10.1007/s10517-011-1453-2. Bull Exp Biol Med. 2011. PMID: 22803040 English, Russian.
Ladasten was injected 5 times in doses of 30 and 50 mg/kg. LPS was administered 1 h after the last injection of the test agents. ...Further studies should be performed to develop new indications for the use of ladasten in adjuvant therapy of depression....
Ladasten was injected 5 times in doses of 30 and 50 mg/kg. LPS was administered 1 h after the last injection of the test agents. ...F
[Effect of antiasthenic drug ladasten on the level of cytokines and behavior in experimental model of anxious depression in C57BL/6 male mice].
Tallerova AV, Kovalenko LP, Durnev AD, Seredenin SB. Tallerova AV, et al. Eksp Klin Farmakol. 2011;74(11):3-5. Eksp Klin Farmakol. 2011. PMID: 22288152 Russian.
Thus, the antiasthenic drug ladasten limits development of the anxious depressive state and suppresses the level ofproinflammatory cytokines IL-6, IL-17 and IL-4. These findings suggest that ladasten is a possible candidate drug for adjuvant therapy of depressive di …
Thus, the antiasthenic drug ladasten limits development of the anxious depressive state and suppresses the level ofproinflammatory cy …
Correcting effect of ladasten on variations in the subpopulation composition of T lymphocytes in C57BL/6 mice on the experimental model of an anxious-depressive state.
Tallerova AV, Kovalenko LP, Kuznetsova OS, Durnev AD, Seredenin SB. Tallerova AV, et al. Bull Exp Biol Med. 2014 Jan;156(3):335-7. doi: 10.1007/s10517-014-2343-1. Epub 2014 Jan 16. Bull Exp Biol Med. 2014. PMID: 24771370
We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompetent organs of male C57Bl/6 mice during modeling of an anxious-depressive state (chronic zoosocial stress). Stress exposure of animals for 30 …
We studied the effect of Ladasten (30 mg/kg intraperitoneally for 5 days) on the subpopulation composition of T cells in immunocompet …
Proteomic analysis and identification of ladasten target proteins in rat brain.
Yamidanov RS, Salimgareeva MKh, Sadovnikov SV, Vakhitova YV, Govorun VM, Seredenin SB. Yamidanov RS, et al. Bull Exp Biol Med. 2010 Nov;149(6):775-8. doi: 10.1007/s10517-010-1050-9. Bull Exp Biol Med. 2010. PMID: 21165444
Two-dimensional electrophoresis and mass spectrometry detection were used to evaluate the range of proteins in rat brain after single treatment with ladasten (50 mg/kg). We identified 13 proteins with various levels of expression....
Two-dimensional electrophoresis and mass spectrometry detection were used to evaluate the range of proteins in rat brain after single treatm …
Time course of histone deacetylase 1 and acetylated H3 and H4 histones in the brain of rats treated with ladasten.
Salimgareeva MKh, Sadovnikov SV, Yamidanov RS, Vakhitova YV, Seredenin SB. Salimgareeva MKh, et al. Bull Exp Biol Med. 2011 Mar;150(5):603-6. doi: 10.1007/s10517-011-1201-7. Bull Exp Biol Med. 2011. PMID: 22235395
We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetylase 1 (HDAC1) and levels of acetylated histones H3 (Lys9) and H4 (Lys8) in the striatum, hippocampus, and hypothalamus. Ladasten redu …
We studied the effects of single intragastric administration of ladasten in a dose of 50 mg/kg on the time course of histone deacetyl …
[Ladasten versus placebo effect self-evaluated by neurasthenia patients with different EEG alpha rhythm types].
Neznamov GG, Bochkarev VK, Reutova MA, Shabanova AA, Siuniakov SA. Neznamov GG, et al. Eksp Klin Farmakol. 2012;75(5):7-13. Eksp Klin Farmakol. 2012. PMID: 22834121 Clinical Trial. Russian.
The self-assessment of the effect of single test doses of ladasten and placebo was independent of the individual differences of EEG alpha rhythm organization and personal traits with respect to tolerability, wish to continue the treatment, activating and calming effects. I …
The self-assessment of the effect of single test doses of ladasten and placebo was independent of the individual differences of EEG a …
62 results