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1.

RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.

Martínez-Riaño A, Bovolenta ER, Boccasavia VL, Ponomarenko J, Abia D, Oeste CL, Fresno M, van Santen HM, Alarcon B.

J Exp Med. 2019 Oct 7;216(10):2427-2447. doi: 10.1084/jem.20181959. Epub 2019 Jul 19.

PMID:
31324740
2.

Constraints on Minute-Scale Transient Astrophysical Neutrino Sources.

Aartsen MG, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Al Samarai I, Altmann D, Andeen K, Anderson T, Ansseau I, Anton G, Argüelles C, Auffenberg J, Axani S, Backes P, Bagherpour H, Bai X, Barbano A, Barron JP, Barwick SW, Baum V, Bay R, Beatty JJ, Becker Tjus J, Becker KH, BenZvi S, Berley D, Bernardini E, Besson DZ, Binder G, Bindig D, Blaufuss E, Blot S, Bohm C, Börner M, Bos F, Böser S, Botner O, Bourbeau E, Bourbeau J, Bradascio F, Braun J, Brenzke M, Bretz HP, Bron S, Brostean-Kaiser J, Burgman A, Busse RS, Carver T, Cheung E, Chirkin D, Christov A, Clark K, Classen L, Collin GH, Conrad JM, Coppin P, Correa P, Cowen DF, Cross R, Dave P, Day M, de André JPAM, De Clercq C, DeLaunay JJ, Dembinski H, Deoskar K, De Ridder S, Desiati P, de Vries KD, de Wasseige G, de With M, DeYoung T, Díaz-Vélez JC, di Lorenzo V, Dujmovic H, Dumm JP, Dunkman M, Dvorak E, Eberhardt B, Ehrhardt T, Eichmann B, Eller P, Evans PA, Evenson PA, Fahey S, Fazely AR, Felde J, Filimonov K, Finley C, Franckowiak A, Friedman E, Fritz A, Gaisser TK, Gallagher J, Ganster E, Gerhardt L, Ghorbani K, Giang W, Glauch T, Glüsenkamp T, Goldschmidt A, Gonzalez JG, Grant D, Griffith Z, Haack C, Hallgren A, Halve L, Halzen F, Hanson K, Hebecker D, Heereman D, Helbing K, Hellauer R, Hickford S, Hignight J, Hill GC, Hoffman KD, Hoffmann R, Hoinka T, Hokanson-Fasig B, Hoshina K, Huang F, Huber M, Hultqvist K, Hünnefeld M, Hussain R, In S, Iovine N, Ishihara A, Jacobi E, Japaridze GS, Jeong M, Jero K, Jones BJP, Kalaczynski P, Kang W, Kappes A, Kappesser D, Karg T, Karle A, Katz U, Kauer M, Keivani A, Kelley JL, Kheirandish A, Kim J, Kintscher T, Kiryluk J, Kittler T, Klein SR, Koirala R, Kolanoski H, Köpke L, Kopper C, Kopper S, Koschinsky JP, Koskinen DJ, Kowalski M, Krings K, Kroll M, Krückl G, Kunwar S, Kurahashi N, Kyriacou A, Labare M, Lanfranchi JL, Larson MJ, Lauber F, Leonard K, Leuermann M, Liu QR, Lohfink E, Lozano Mariscal CJ, Lu L, Lünemann J, Luszczak W, Madsen J, Maggi G, Mahn KBM, Makino Y, Mancina S, Mariş IC, Maruyama R, Mase K, Maunu R, Meagher K, Medici M, Meier M, Menne T, Merino G, Meures T, Miarecki S, Micallef J, Momenté G, Montaruli T, Moore RW, Moulai M, Nagai R, Nahnhauer R, Nakarmi P, Naumann U, Neer G, Niederhausen H, Nowicki SC, Nygren DR, Obertacke Pollmann A, Olivas A, O'Murchadha A, Osborne JP, O'Sullivan E, Palczewski T, Pandya H, Pankova DV, Peiffer P, Pepper JA, Pérez de Los Heros C, Pieloth D, Pinat E, Pizzuto A, Plum M, Price PB, Przybylski GT, Raab C, Rameez M, Rauch L, Rawlins K, Rea IC, Reimann R, Relethford B, Renzi G, Resconi E, Rhode W, Richman M, Robertson S, Rongen M, Rott C, Ruhe T, Ryckbosch D, Rysewyk D, Safa I, Sanchez Herrera SE, Sandrock A, Sandroos J, Santander M, Sarkar S, Sarkar S, Satalecka K, Schaufel M, Schlunder P, Schmidt T, Schneider A, Schneider J, Schöneberg S, Schumacher L, Sclafani S, Seckel D, Seunarine S, Soedingrekso J, Soldin D, Song M, Spiczak GM, Spiering C, Stachurska J, Stamatikos M, Stanev T, Stasik A, Stein R, Stettner J, Steuer A, Stezelberger T, Stokstad RG, Stößl A, Strotjohann NL, Stuttard T, Sullivan GW, Sutherland M, Taboada I, Tenholt F, Ter-Antonyan S, Terliuk A, Tilav S, Toale PA, Tobin MN, Tönnis C, Toscano S, Tosi D, Tselengidou M, Tung CF, Turcati A, Turley CF, Ty B, Unger E, Unland Elorrieta MA, Usner M, Vandenbroucke J, Van Driessche W, van Eijk D, van Eijndhoven N, Vanheule S, van Santen J, Vraeghe M, Walck C, Wallace A, Wallraff M, Wandler FD, Wandkowsky N, Watson TB, Waza A, Weaver C, Weiss MJ, Wendt C, Werthebach J, Westerhoff S, Whelan BJ, Whitehorn N, Wiebe K, Wiebusch CH, Wille L, Williams DR, Wills L, Wolf M, Wood J, Wood TR, Woolsey E, Woschnagg K, Wrede G, Xu DL, Xu XW, Xu Y, Yanez JP, Yodh G, Yoshida S, Yuan T.

Phys Rev Lett. 2019 Feb 8;122(5):051102. doi: 10.1103/PhysRevLett.122.051102.

3.

Measurement of Atmospheric Neutrino Oscillations at 6-56 GeV with IceCube DeepCore.

Aartsen MG, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Al Samarai I, Altmann D, Andeen K, Anderson T, Ansseau I, Anton G, Argüelles C, Auffenberg J, Axani S, Bagherpour H, Bai X, Barron JP, Barwick SW, Baum V, Bay R, Beatty JJ, Becker Tjus J, Becker KH, BenZvi S, Berley D, Bernardini E, Besson DZ, Binder G, Bindig D, Blaufuss E, Blot S, Bohm C, Börner M, Bos F, Bose D, Böser S, Botner O, Bourbeau J, Bradascio F, Braun J, Brayeur L, Brenzke M, Bretz HP, Bron S, Brostean-Kaiser J, Burgman A, Carver T, Casey J, Casier M, Cheung E, Chirkin D, Christov A, Clark K, Classen L, Coenders S, Collin GH, Conrad JM, Cowen DF, Cross R, Day M, de André JPAM, De Clercq C, DeLaunay JJ, Dembinski H, De Ridder S, Desiati P, de Vries KD, de Wasseige G, de With M, DeYoung T, Díaz-Vélez JC, di Lorenzo V, Dujmovic H, Dumm JP, Dunkman M, Eberhardt B, Ehrhardt T, Eichmann B, Eller P, Evenson PA, Fahey S, Fazely AR, Felde J, Filimonov K, Finley C, Flis S, Franckowiak A, Friedman E, Fuchs T, Gaisser TK, Gallagher J, Gerhardt L, Ghorbani K, Giang W, Glauch T, Glüsenkamp T, Goldschmidt A, Gonzalez JG, Grant D, Griffith Z, Haack C, Hallgren A, Halzen F, Hanson K, Hebecker D, Heereman D, Helbing K, Hellauer R, Hickford S, Hignight J, Hill GC, Hoffman KD, Hoffmann R, Hokanson-Fasig B, Hoshina K, Huang F, Huber M, Hultqvist K, Hünnefeld M, In S, Ishihara A, Jacobi E, Japaridze GS, Jeong M, Jero K, Jones BJP, Kalaczynski P, Kang W, Kappes A, Karg T, Karle A, Katz U, Kauer M, Keivani A, Kelley JL, Kheirandish A, Kim J, Kim M, Kintscher T, Kiryluk J, Kittler T, Klein SR, Kohnen G, Koirala R, Kolanoski H, Köpke L, Kopper C, Kopper S, Koschinsky JP, Koskinen DJ, Kowalski M, Krings K, Kroll M, Krückl G, Kunnen J, Kunwar S, Kurahashi N, Kuwabara T, Kyriacou A, Labare M, Lanfranchi JL, Larson MJ, Lauber F, Lennarz D, Lesiak-Bzdak M, Leuermann M, Liu QR, Lu L, Lünemann J, Luszczak W, Madsen J, Maggi G, Mahn KBM, Mancina S, Maruyama R, Mase K, Maunu R, McNally F, Meagher K, Medici M, Meier M, Menne T, Merino G, Meures T, Miarecki S, Micallef J, Momenté G, Montaruli T, Moore RW, Moulai M, Nahnhauer R, Nakarmi P, Naumann U, Neer G, Niederhausen H, Nowicki SC, Nygren DR, Obertacke Pollmann A, Olivas A, O'Murchadha A, Palczewski T, Pandya H, Pankova DV, Peiffer P, Pepper JA, Pérez de Los Heros C, Pieloth D, Pinat E, Plum M, Price PB, Przybylski GT, Raab C, Rädel L, Rameez M, Rawlins K, Rea IC, Reimann R, Relethford B, Relich M, Resconi E, Rhode W, Richman M, Robertson S, Rongen M, Rott C, Ruhe T, Ryckbosch D, Rysewyk D, Sälzer T, Sanchez Herrera SE, Sandrock A, Sandroos J, Sarkar S, Sarkar S, Satalecka K, Schlunder P, Schmidt T, Schneider A, Schoenen S, Schöneberg S, Schumacher L, Seckel D, Seunarine S, Soedingrekso J, Soldin D, Song M, Spiczak GM, Spiering C, Stachurska J, Stamatikos M, Stanev T, Stasik A, Stettner J, Steuer A, Stezelberger T, Stokstad RG, Stößl A, Strotjohann NL, Sullivan GW, Sutherland M, Taboada I, Tatar J, Tenholt F, Ter-Antonyan S, Terliuk A, Tešić G, Tilav S, Toale PA, Tobin MN, Toscano S, Tosi D, Tselengidou M, Tung CF, Turcati A, Turley CF, Ty B, Unger E, Usner M, Vandenbroucke J, Van Driessche W, van Eijndhoven N, Vanheule S, van Santen J, Vehring M, Vogel E, Vraeghe M, Walck C, Wallace A, Wallraff M, Wandler FD, Wandkowsky N, Waza A, Weaver C, Weiss MJ, Wendt C, Werthebach J, Westerhoff S, Whelan BJ, Wiebe K, Wiebusch CH, Wille L, Williams DR, Wills L, Wolf M, Wood J, Wood TR, Woolsey E, Woschnagg K, Xu DL, Xu XW, Xu Y, Yanez JP, Yodh G, Yoshida S, Yuan T, Zoll M; IceCube Collaboration.

Phys Rev Lett. 2018 Feb 16;120(7):071801. doi: 10.1103/PhysRevLett.120.071801.

4.

Search for neutrinos from decaying dark matter with IceCube: IceCube Collaboration.

Aartsen MG, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Samarai IA, Altmann D, Andeen K, Anderson T, Ansseau I, Anton G, Argüelles C, Auffenberg J, Axani S, Backes P, Bagherpour H, Bai X, Barron JP, Barwick SW, Baum V, Bay R, Beatty JJ, Becker Tjus J, Becker KH, BenZvi S, Berley D, Bernardini E, Besson DZ, Binder G, Bindig D, Blaufuss E, Blot S, Bohm C, Börner M, Bos F, Böser S, Botner O, Bourbeau E, Bourbeau J, Bradascio F, Braun J, Brenzke M, Bretz HP, Bron S, Brostean-Kaiser J, Burgman A, Busse RS, Carver T, Cheung E, Chirkin D, Christov A, Clark K, Classen L, Collin GH, Conrad JM, Coppin P, Correa P, Cowen DF, Cross R, Dave P, Day M, de André JPAM, De Clercq C, DeLaunay JJ, Dembinski H, De Ridder S, Desiati P, de Vries KD, de Wasseige G, de With M, DeYoung T, Díaz-Vélez JC, di Lorenzo V, Dujmovic H, Dumm JP, Dunkman M, Dvorak E, Eberhardt B, Ehrhardt T, Eichmann B, Eller P, Evenson PA, Fahey S, Fazely AR, Felde J, Filimonov K, Finley C, Flis S, Franckowiak A, Friedman E, Fritz A, Gaisser TK, Gallagher J, Ganster E, Gerhardt L, Ghorbani K, Giang W, Glauch T, Glüsenkamp T, Goldschmidt A, Gonzalez JG, Grant D, Griffith Z, Haack C, Hallgren A, Halve L, Halzen F, Hanson K, Hebecker D, Heereman D, Helbing K, Hellauer R, Hickford S, Hignight J, Hill GC, Hoffman KD, Hoffmann R, Hoinka T, Hokanson-Fasig B, Hoshina K, Huang F, Huber M, Hultqvist K, Hünnefeld M, Hussain R, In S, Iovine N, Ishihara A, Jacobi E, Japaridze GS, Jeong M, Jero K, Jones BJP, Kalaczynski P, Kang W, Kappes A, Kappesser D, Karg T, Karle A, Katz U, Kauer M, Keivani A, Kelley JL, Kheirandish A, Kim J, Kim M, Kintscher T, Kiryluk J, Kittler T, Klein SR, Koirala R, Kolanoski H, Köpke L, Kopper C, Kopper S, Koschinsky JP, Koskinen DJ, Kowalski M, Krings K, Kroll M, Krückl G, Kunwar S, Kurahashi N, Kuwabara T, Kyriacou A, Labare M, Lanfranchi JL, Larson MJ, Lauber F, Leonard K, Lesiak-Bzdak M, Leuermann M, Liu QR, Lohfink E, Mariscal CJL, Lu L, Lünemann J, Luszczak W, Madsen J, Maggi G, Mahn KBM, Mancina S, Maruyama R, Mase K, Maunu R, Meagher K, Medici M, Meier M, Menne T, Merino G, Meures T, Miarecki S, Micallef J, Momenté G, Montaruli T, Moore RW, Moulai M, Nahnhauer R, Nakarmi P, Naumann U, Neer G, Niederhausen H, Nowicki SC, Nygren DR, Obertacke Pollmann A, Olivas A, O'Murchadha A, O'Sullivan E, Palczewski T, Pandya H, Pankova DV, Peiffer P, Pepper JA, Pérez de Los Heros C, Pieloth D, Pinat E, Plum M, Price PB, Przybylski GT, Raab C, Rädel L, Rameez M, Rauch L, Rawlins K, Rea IC, Reimann R, Relethford B, Relich M, Resconi E, Rhode W, Richman M, Robertson S, Rongen M, Rott C, Ruhe T, Ryckbosch D, Rysewyk D, Safa I, Sanchez Herrera SE, Sandrock A, Sandroos J, Santander M, Sarkar S, Sarkar S, Satalecka K, Schaufel M, Schlunder P, Schmidt T, Schneider A, Schoenen S, Schöneberg S, Schumacher L, Sclafani S, Seckel D, Seunarine S, Soedingrekso J, Soldin D, Song M, Spiczak GM, Spiering C, Stachurska J, Stamatikos M, Stanev T, Stasik A, Stein R, Stettner J, Steuer A, Stezelberger T, Stokstad RG, Stößl A, Strotjohann NL, Stuttard T, Sullivan GW, Sutherland M, Taboada I, Tatar J, Tenholt F, Ter-Antonyan S, Terliuk A, Tilav S, Toale PA, Tobin MN, Tönnis C, Toscano S, Tosi D, Tselengidou M, Tung CF, Turcati A, Turley CF, Ty B, Unger E, Usner M, Vandenbroucke J, Van Driessche W, van Eijk D, van Eijndhoven N, Vanheule S, van Santen J, Vraeghe M, Walck C, Wallace A, Wallraff M, Wandler FD, Wandkowsky N, Waza A, Weaver C, Weiss MJ, Wendt C, Werthebach J, Westerhoff S, Whelan BJ, Wiebe K, Wiebusch CH, Wille L, Williams DR, Wills L, Wolf M, Wood J, Wood TR, Woolsey E, Woschnagg K, Wrede G, Xu DL, Xu XW, Xu Y, Yanez JP, Yodh G, Yoshida S, Yuan T.

Eur Phys J C Part Fields. 2018;78(10):831. doi: 10.1140/epjc/s10052-018-6273-3. Epub 2018 Oct 16.

5.

Receptor Pre-Clustering and T cell Responses: Insights into Molecular Mechanisms.

Castro M, van Santen HM, Férez M, Alarcón B, Lythe G, Molina-París C.

Front Immunol. 2014 Apr 30;5:132. doi: 10.3389/fimmu.2014.00132. eCollection 2014. Review.

6.

Cognate peptide-MHC complexes are expressed as tightly apposed nanoclusters in virus-infected cells to allow TCR crosslinking.

Ferez M, Castro M, Alarcon B, van Santen HM.

J Immunol. 2014 Jan 1;192(1):52-8. doi: 10.4049/jimmunol.1301224. Epub 2013 Dec 4.

7.

Visualization of TCR nanoclusters via immunogold labeling, freeze-etching, and surface replication.

Fiala GJ, Rejas MT, Schamel WW, van Santen HM.

Methods Cell Biol. 2013;117:391-410. doi: 10.1016/B978-0-12-408143-7.00021-9.

PMID:
24143989
8.

Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.

Bains I, van Santen HM, Seddon B, Yates AJ.

PLoS Comput Biol. 2013;9(7):e1003102. doi: 10.1371/journal.pcbi.1003102. Epub 2013 Jul 25.

9.

Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.

Kumar R, Ferez M, Swamy M, Arechaga I, Rejas MT, Valpuesta JM, Schamel WW, Alarcon B, van Santen HM.

Immunity. 2011 Sep 23;35(3):375-87. doi: 10.1016/j.immuni.2011.08.010. Epub 2011 Sep 8.

10.

Receptors, signaling networks, and disease.

Cuesta N, Martín-Cófreces NB, Murga C, van Santen HM.

Sci Signal. 2011 Feb 22;4(161):mr3. doi: 10.1126/scisignal.2001687.

PMID:
21343616
11.

Two receptors, two kinases, and T cell lineage determination.

Alarcón B, van Santen HM.

Sci Signal. 2010 Mar 23;3(114):pe11. doi: 10.1126/scisignal.3114pe11. Review.

PMID:
20332426
12.

Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation.

Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15460-5. Epub 2007 Sep 19.

13.

A conformational change senses the strength of T cell receptor-ligand interaction during thymic selection.

Risueño RM, van Santen HM, Alarcón B.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9625-30. Epub 2006 Jun 9.

14.

T-cell antigen-receptor stoichiometry: pre-clustering for sensitivity.

Alarcón B, Swamy M, van Santen HM, Schamel WW.

EMBO Rep. 2006 May;7(5):490-5. Review.

15.

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.

Schamel WW, Arechaga I, Risueño RM, van Santen HM, Cabezas P, Risco C, Valpuesta JM, Alarcón B.

J Exp Med. 2005 Aug 15;202(4):493-503. Epub 2005 Aug 8.

16.

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response.

Obst R, van Santen HM, Mathis D, Benoist C.

J Exp Med. 2005 May 16;201(10):1555-65.

17.

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

van Santen HM, Benoist C, Mathis D.

J Exp Med. 2004 Nov 15;200(10):1221-30. Epub 2004 Nov 8.

18.

A cassette vector for high-level reporter expression driven by a hybrid invariant chain promoter in transgenic mice.

van Santen H, Benoist C, Mathis D.

J Immunol Methods. 2000 Nov 1;245(1-2):133-7.

PMID:
11042290
19.

Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection.

Mazzaccaro RJ, Gedde M, Jensen ER, van Santen HM, Ploegh HL, Rock KL, Bloom BR.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11786-91.

20.

Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.

Tourne S, van Santen HM, van Roon M, Berns A, Benoist C, Mathis D, Ploegh H.

Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1464-9.

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