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Items: 1 to 20 of 125


High-throughput, image-based screening of pooled genetic-variant libraries.

Emanuel G, Moffitt JR, Zhuang X.

Nat Methods. 2017 Dec;14(12):1159-1162. doi: 10.1038/nmeth.4495. Epub 2017 Oct 30.


In Situ Super-Resolution Imaging of Genomic DNA with OligoSTORM and OligoDNA-PAINT.

Beliveau BJ, Boettiger AN, Nir G, Bintu B, Yin P, Zhuang X, Wu CT.

Methods Mol Biol. 2017;1663:231-252. doi: 10.1007/978-1-4939-7265-4_19.


Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.

Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D.

Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7.


Structural organization of the actin-spectrin-based membrane skeleton in dendrites and soma of neurons.

Han B, Zhou R, Xia C, Zhuang X.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6678-E6685. doi: 10.1073/pnas.1705043114. Epub 2017 Jul 24.


Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster.

Lee YCG, Yang Q, Chi W, Turkson SA, Du WA, Kemkemer C, Zeng ZB, Long M, Zhuang X.

Genome Biol Evol. 2017 May 1;9(5):1357-1369. doi: 10.1093/gbe/evx089.


The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction.

Timashev LA, Babcock H, Zhuang X, de Lange T.

Genes Dev. 2017 Mar 15;31(6):578-589. doi: 10.1101/gad.294108.116. Epub 2017 Apr 5.


Analyzing Single Molecule Localization Microscopy Data Using Cubic Splines.

Babcock HP, Zhuang X.

Sci Rep. 2017 Apr 3;7(1):552. doi: 10.1038/s41598-017-00622-w.


CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility.

Chung JJ, Miki K, Kim D, Shim SH, Shi HF, Hwang JY, Cai X, Iseri Y, Zhuang X, Clapham DE.

Elife. 2017 Feb 23;6. pii: e23082. doi: 10.7554/eLife.23082.


Picornavirus RNA is protected from cleavage by ribonuclease during virion uncoating and transfer across cellular and model membranes.

Groppelli E, Levy HC, Sun E, Strauss M, Nicol C, Gold S, Zhuang X, Tuthill TJ, Hogle JM, Rowlands DJ.

PLoS Pathog. 2017 Feb 6;13(2):e1006197. doi: 10.1371/journal.ppat.1006197. eCollection 2017 Feb.


High-performance multiplexed fluorescence in situ hybridization in culture and tissue with matrix imprinting and clearing.

Moffitt JR, Hao J, Bambah-Mukku D, Lu T, Dulac C, Zhuang X.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14456-14461. Epub 2016 Nov 22.


Quantitative assessment of polymorphisms in H19 lncRNA and cancer risk: a meta-analysis of 13,392 cases and 18,893 controls.

Chu M, Yuan W, Wu S, Wang Z, Mao L, Tian T, Lu Y, Zhu B, Yang Y, Wang B, Gao H, Jiang L, Zhuang X.

Oncotarget. 2016 Nov 29;7(48):78631-78639. doi: 10.18632/oncotarget.12530. Review.


High-throughput single-cell gene-expression profiling with multiplexed error-robust fluorescence in situ hybridization.

Moffitt JR, Hao J, Wang G, Chen KH, Babcock HP, Zhuang X.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11046-51. doi: 10.1073/pnas.1612826113. Epub 2016 Sep 13.


Spatial organization of chromatin domains and compartments in single chromosomes.

Wang S, Su JH, Beliveau BJ, Bintu B, Moffitt JR, Wu CT, Zhuang X.

Science. 2016 Aug 5;353(6299):598-602. doi: 10.1126/science.aaf8084. Epub 2016 Jul 21.


RNA Imaging with Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH).

Moffitt JR, Zhuang X.

Methods Enzymol. 2016;572:1-49. doi: 10.1016/bs.mie.2016.03.020. Epub 2016 Apr 27.


An RNA-aptamer-based two-color CRISPR labeling system.

Wang S, Su JH, Zhang F, Zhuang X.

Sci Rep. 2016 May 27;6:26857. doi: 10.1038/srep26857.


Spatial organization shapes the turnover of a bacterial transcriptome.

Moffitt JR, Pandey S, Boettiger AN, Wang S, Zhuang X.

Elife. 2016 May 20;5. pii: e13065. doi: 10.7554/eLife.13065.


Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, Zhuang X.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6029-34. doi: 10.1073/pnas.1605707113. Epub 2016 May 9.


Real-Time Imaging of Translation on Single mRNA Transcripts in Live Cells.

Wang C, Han B, Zhou R, Zhuang X.

Cell. 2016 May 5;165(4):990-1001. doi: 10.1016/j.cell.2016.04.040.


Quantitative Assessment of the Polymorphisms in the HOTAIR lncRNA and Cancer Risk: A Meta-Analysis of 8 Case-Control Studies.

Tian T, Li C, Xiao J, Shen Y, Lu Y, Jiang L, Zhuang X, Chu M.

PLoS One. 2016 Mar 24;11(3):e0152296. doi: 10.1371/journal.pone.0152296. eCollection 2016.


Spatial colocalization and functional link of purinosomes with mitochondria.

French JB, Jones SA, Deng H, Pedley AM, Kim D, Chan CY, Hu H, Pugh RJ, Zhao H, Zhang Y, Huang TJ, Fang Y, Zhuang X, Benkovic SJ.

Science. 2016 Feb 12;351(6274):733-7. doi: 10.1126/science.aac6054.

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