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Items: 1 to 20 of 44


Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.

De Rossi P, Andrew RJ, Musial TF, Buggia-Prevot V, Xu G, Ponnusamy M, Ly H, Krause SV, Rice RC, de l'Estoile V, Valin T, Salem S, Despa F, Borchelt DR, Bindokas VP, Nicholson DA, Thinakaran G.

Brain Pathol. 2019 Jul;29(4):485-501. doi: 10.1111/bpa.12687. Epub 2018 Dec 27.


Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease.

Pace MC, Xu G, Fromholt S, Howard J, Crosby K, Giasson BI, Lewis J, Borchelt DR.

Acta Neuropathol. 2018 Dec;136(6):919-938. doi: 10.1007/s00401-018-1895-y. Epub 2018 Aug 23.


Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology.

Pace MC, Xu G, Fromholt S, Howard J, Giasson BI, Lewis J, Borchelt DR.

Mol Neurodegener. 2018 May 18;13(1):23. doi: 10.1186/s13024-018-0253-9.


Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy.

Iradi MCG, Triplett JC, Thomas JD, Davila R, Crown AM, Brown H, Lewis J, Swanson MS, Xu G, Rodriguez-Lebron E, Borchelt DR.

Sci Rep. 2018 Mar 6;8(1):4049. doi: 10.1038/s41598-018-21371-4.


Vulnerability of newly synthesized proteins to proteostasis stress.

Xu G, Pattamatta A, Hildago R, Pace MC, Brown H, Borchelt DR.

J Cell Sci. 2016 May 1;129(9):1892-901. doi: 10.1242/jcs.176479. Epub 2016 Mar 29.


Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.

Xu G, Ran Y, Fromholt SE, Fu C, Yachnis AT, Golde TE, Borchelt DR.

Acta Neuropathol Commun. 2015 Nov 14;3:72. doi: 10.1186/s40478-015-0252-9.


Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains.

Janus C, Flores AY, Xu G, Borchelt DR.

Neurobiol Aging. 2015 Sep;36(9):2519-32. doi: 10.1016/j.neurobiolaging.2015.05.010. Epub 2015 May 21.


Substantially elevating the levels of αB-crystallin in spinal motor neurons of mutant SOD1 mice does not significantly delay paralysis or attenuate mutant protein aggregation.

Xu G, Fromholt S, Ayers JI, Brown H, Siemienski Z, Crosby KW, Mayer CA, Janus C, Borchelt DR.

J Neurochem. 2015 May;133(3):452-64. doi: 10.1111/jnc.13022. Epub 2015 Jan 26.


Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

Xu G, Ayers JI, Roberts BL, Brown H, Fromholt S, Green C, Borchelt DR.

Hum Mol Genet. 2015 Feb 15;24(4):1019-35. doi: 10.1093/hmg/ddu517. Epub 2014 Oct 9.


Experimental transmissibility of mutant SOD1 motor neuron disease.

Ayers JI, Fromholt S, Koch M, DeBosier A, McMahon B, Xu G, Borchelt DR.

Acta Neuropathol. 2014 Dec;128(6):791-803. doi: 10.1007/s00401-014-1342-7. Epub 2014 Sep 28.


Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.

Tebbenkamp AT, Xu G, Siemienski ZB, Janus C, Fromholt SE, Brown HH, Swing D, Tessarollo L, Borchelt DR.

J Huntingtons Dis. 2014;3(1):73-86. doi: 10.3233/JHD-130087.


Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases.

Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR.

Acta Neuropathol Commun. 2014 May 14;2:55. doi: 10.1186/2051-5960-2-55.


Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.

Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI.

Brain Res. 2013 Aug 2;1524:62-73. doi: 10.1016/j.brainres.2013.06.006. Epub 2013 Jun 15.


Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

Price AR, Xu G, Siemienski ZB, Smithson LA, Borchelt DR, Golde TE, Felsenstein KM.

Science. 2013 May 24;340(6135):924-d. doi: 10.1126/science.1234089.


Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy.

Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, Petrucelli L, Sahara N, Dickson DW, Giasson B, Lewis J.

Acta Neuropathol. 2013 Jul;126(1):39-50. doi: 10.1007/s00401-013-1123-8. Epub 2013 May 11.


Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis.

Xu G, Stevens SM Jr, Moore BD, McClung S, Borchelt DR.

Hum Mol Genet. 2013 Jul 15;22(14):2765-74. doi: 10.1093/hmg/ddt121. Epub 2013 Mar 19.


Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis.

Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko A, Borchelt DR.

J Neurosci. 2013 Feb 27;33(9):3765-79. doi: 10.1523/JNEUROSCI.4251-12.2013.


Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell lines.

Xu G, Stevens SM Jr, Kobeissy F, Brown H, McClung S, Gold MS, Borchelt DR.

PLoS One. 2012;7(11):e49021. doi: 10.1371/journal.pone.0049021. Epub 2012 Nov 8. Erratum in: PLoS One. 2012;7(11). doi:10.1371/annotation/82b96c01-6435-4856-80a6-0176b1986e32. Kobiessy, Firas [corrected to Kobeissy, Firas].


Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.

Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR.

Hum Mol Genet. 2011 Jul 15;20(14):2770-82. doi: 10.1093/hmg/ddr176. Epub 2011 Apr 22.

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