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Items: 1 to 20 of 35

1.

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.

Lin S, Ptasinska A, Chen X, Shrestha M, Assi SA, Chin PS, Imperato MR, Aronow BJ, Zhang J, Weirauch MT, Bonifer C, Mulloy JC.

Blood. 2017 Sep 7;130(10):1213-1222. doi: 10.1182/blood-2016-11-750976. Epub 2017 Jul 14.

PMID:
28710059
2.

AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia.

Zhou F, Liu Y, Rohde C, Pauli C, Gerloff D, Köhn M, Misiak D, Bäumer N, Cui C, Göllner S, Oellerich T, Serve H, Garcia-Cuellar MP, Slany R, Maciejewski JP, Przychodzen B, Seliger B, Klein HU, Bartenhagen C, Berdel WE, Dugas M, Taketo MM, Farouq D, Schwartz S, Regev A, Hébert J, Sauvageau G, Pabst C, Hüttelmaier S, Müller-Tidow C.

Nat Cell Biol. 2017 Jul;19(7):844-855. doi: 10.1038/ncb3563. Epub 2017 Jun 26.

PMID:
28650479
3.

Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expression.

Liao KH, Chang SJ, Chang HC, Chien CL, Huang TS, Feng TC, Lin WW, Shih CC, Yang MH, Yang SH, Lin CH, Hwang WL, Lee OK.

PLoS One. 2017 Jun 22;12(6):e0179758. doi: 10.1371/journal.pone.0179758. eCollection 2017.

4.

An AML1-ETO/miR-29b-1 regulatory circuit modulates phenotypic properties of acute myeloid leukemia cells.

Zaidi SK, Perez AW, White ES, Lian JB, Stein JL, Stein GS.

Oncotarget. 2017 Jun 20;8(25):39994-40005. doi: 10.18632/oncotarget.18127.

5.

A novel epigenetic <i>AML1-ETO/THAP10/miR-383</i> mini-circuitry contributes to t(8;21) leukaemogenesis.

Li Y, Ning Q, Shi J, Chen Y, Jiang M, Gao L, Huang W, Jing Y, Huang S, Liu A, Hu Z, Liu D, Wang L, Nervi C, Dai Y, Zhang MQ, Yu L.

EMBO Mol Med. 2017 Jul;9(7):933-949. doi: 10.15252/emmm.201607180.

6.

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.

Loke J, Assi SA, Imperato MR, Ptasinska A, Cauchy P, Grabovska Y, Soria NM, Raghavan M, Delwel HR, Cockerill PN, Heidenreich O, Bonifer C.

Cell Rep. 2017 May 23;19(8):1654-1668. doi: 10.1016/j.celrep.2017.05.005.

7.

Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner.

Man N, Tan Y, Sun XJ, Liu F, Cheng G, Greenblatt SM, Martinez C, Karl DL, Ando K, Sun M, Hou D, Chen B, Xu M, Yang FC, Chen Z, Chen S, Nimer SD, Wang L.

Blood. 2017 May 18;129(20):2782-2792. doi: 10.1182/blood-2016-10-745034. Epub 2017 Apr 5.

8.

Assessing the miRNA sponge potential of RUNX1T1 in t(8;21) acute myeloid leukemia.

Junge A, Zandi R, Havgaard JH, Gorodkin J, Cowland JB.

Gene. 2017 Jun 5;615:35-40. doi: 10.1016/j.gene.2017.03.015. Epub 2017 Mar 16.

PMID:
28322996
9.

RUNX1-ETO Leukemia.

Lin S, Mulloy JC, Goyama S.

Adv Exp Med Biol. 2017;962:151-173. doi: 10.1007/978-981-10-3233-2_11. Review.

PMID:
28299657
10.

The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia.

Qin YZ, Wang Y, Xu LP, Zhang XH, Chen H, Han W, Chen YH, Wang FR, Wang JZ, Chen Y, Mo XD, Zhao XS, Chang YJ, Liu KY, Huang XJ.

J Hematol Oncol. 2017 Feb 6;10(1):44. doi: 10.1186/s13045-017-0414-2.

11.

Cytogenetic and Cytogenomic Microarray Characterization of Chromothripsis in Chromosome 8 Affecting MOZ/NCOA2 (TIF2), FGFR1, RUNX1T1, and RUNX1 in a Pediatric Acute Myeloid Leukemia.

Koduru PR, Wilson K, Wen J, Garcia R, Patel S, Monaghan SA.

J Pediatr Hematol Oncol. 2017 May;39(4):e227-e232. doi: 10.1097/MPH.0000000000000770.

PMID:
28085746
12.

ASXL2 mutations are frequently found in pediatric AML patients with t(8;21)/ RUNX1-RUNX1T1 and associated with a better prognosis.

Yamato G, Shiba N, Yoshida K, Shiraishi Y, Hara Y, Ohki K, Okubo J, Okuno H, Chiba K, Tanaka H, Kinoshita A, Moritake H, Kiyokawa N, Tomizawa D, Park MJ, Sotomatsu M, Taga T, Adachi S, Tawa A, Horibe K, Arakawa H, Miyano S, Ogawa S, Hayashi Y.

Genes Chromosomes Cancer. 2017 May;56(5):382-393. doi: 10.1002/gcc.22443. Epub 2017 Feb 14.

PMID:
28063196
13.

Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.

Zhou B, Li H, Xing C, Ye H, Feng J, Wu J, Lu Z, Fang J, Gao S.

Biochem Pharmacol. 2017 Mar 15;128:12-25. doi: 10.1016/j.bcp.2016.12.022. Epub 2016 Dec 30.

PMID:
28043811
14.

AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis.

Singh AA, Mandoli A, Prange KH, Laakso M, Martens JH.

Oncotarget. 2017 Feb 21;8(8):12855-12865. doi: 10.18632/oncotarget.14150.

15.

The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs.

Mandoli A, Singh AA, Prange KHM, Tijchon E, Oerlemans M, Dirks R, Ter Huurne M, Wierenga ATJ, Janssen-Megens EM, Berentsen K, Sharifi N, Kim B, Matarese F, Nguyen LN, Hubner NC, Rao NA, van den Akker E, Altucci L, Vellenga E, Stunnenberg HG, Martens JHA.

Cell Rep. 2016 Nov 15;17(8):2087-2100. doi: 10.1016/j.celrep.2016.08.082.

16.
17.

A minicircuitry of microRNA-9-1 and RUNX1-RUNX1T1 contributes to leukemogenesis in t(8;21) acute myeloid leukemia.

Fu L, Shi J, Liu A, Zhou L, Jiang M, Fu H, Xu K, Li D, Deng A, Zhang Q, Pang Y, Guo Y, Hu K, Zhou J, Wang Y, Huang W, Jing Y, Dou L, Wang L, Xu K, Ke X, Nervi C, Li Y, Yu L.

Int J Cancer. 2017 Feb 1;140(3):653-661. doi: 10.1002/ijc.30481. Epub 2016 Nov 10.

18.

AML1-ETO promotes SIRT1 expression to enhance leukemogenesis of t(8;21) acute myeloid leukemia.

Zhou L, Wang Q, Chen X, Fu L, Zhang X, Wang L, Deng A, Li D, Liu J, Lv N, Wang L, Li Y, Liu D, Yu L, Dou L.

Exp Hematol. 2017 Feb;46:62-69. doi: 10.1016/j.exphem.2016.09.013. Epub 2016 Oct 8.

PMID:
27725192
19.

Homoharringtonine combined with aclarubicin and cytarabine synergistically induces apoptosis in t(8;21) leukemia cells and triggers caspase-3-mediated cleavage of the AML1-ETO oncoprotein.

Cao J, Feng H, Ding NN, Wu QY, Chen C, Niu MS, Chen W, Qiu TT, Zhu HH, Xu KL.

Cancer Med. 2016 Nov;5(11):3205-3213. doi: 10.1002/cam4.913. Epub 2016 Oct 5.

20.

Amyloid precursor protein cooperates with c-KIT mutation/overexpression to regulate cell apoptosis in AML1-ETO-positive leukemia via the PI3K/AKT signaling pathway.

Yu G, Yin C, Jiang L, Zheng Z, Wang Z, Wang C, Zhou H, Jiang X, Liu Q, Meng F.

Oncol Rep. 2016 Sep;36(3):1626-32. doi: 10.3892/or.2016.4963. Epub 2016 Jul 21.

PMID:
27460334

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