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Items: 1 to 20 of 117


Age-dependent concomitant changes in synaptic dysfunction and GABAergic pathway in the APP/PS1 mouse model.

Oyelami T, Bondt A, den Wyngaert IV, Hoorde KV, Hoskens L, Shaban H, Kemp JA, Drinkenburg WH.

Acta Neurobiol Exp (Wars). 2016;76(4):282-293.


Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.

Hou Y, Wang F, Cheng L, Luo T, Xu J, Wang H.

Neurosci Bull. 2016 Oct;32(5):455-62. doi: 10.1007/s12264-016-0052-7. Epub 2016 Aug 13.


ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.

Letronne F, Laumet G, Ayral AM, Chapuis J, Demiautte F, Laga M, Vandenberghe ME, Malmanche N, Leroux F, Eysert F, Sottejeau Y, Chami L, Flaig A, Bauer C, Dourlen P, Lesaffre M, Delay C, Huot L, Dumont J, Werkmeister E, Lafont F, Mendes T, Hansmannel F, Dermaut B, Deprez B, Hérard AS, Dhenain M, Souedet N, Pasquier F, Tulasne D, Berr C, Hauw JJ, Lemoine Y, Amouyel P, Mann D, Déprez R, Checler F, Hot D, Delzescaux T, Gevaert K, Lambert JC.

EBioMedicine. 2016 Jul;9:278-92. doi: 10.1016/j.ebiom.2016.06.002. Epub 2016 Jun 2.


Cell-free expression of the APP transmembrane fragments with Alzheimer's disease mutations using algal amino acid mixture for structural NMR studies.

Bocharova OV, Urban AS, Nadezhdin KD, Bocharov EV, Arseniev AS.

Protein Expr Purif. 2016 Jul;123:105-11. doi: 10.1016/j.pep.2016.04.004. Epub 2016 Apr 9.


An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling.

Hashimoto Y, Toyama Y, Kusakari S, Nawa M, Matsuoka M.

J Biol Chem. 2016 Jun 3;291(23):12282-93. doi: 10.1074/jbc.M115.698092. Epub 2016 Apr 11.


Regulation of global gene expression and cell proliferation by APP.

Wu Y, Zhang S, Xu Q, Zou H, Zhou W, Cai F, Li T, Song W.

Sci Rep. 2016 Mar 3;6:22460. doi: 10.1038/srep22460.


Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.

Wang Y, Wu F, Pan H, Zheng W, Feng C, Wang Y, Deng Z, Wang L, Luo J, Chen S.

Sci Rep. 2016 Feb 29;6:22244. doi: 10.1038/srep22244.


Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.

Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S.

Acta Neuropathol Commun. 2016 Feb 25;4:16. doi: 10.1186/s40478-016-0282-y.


CABeRNET: a Cytoscape app for augmented Boolean models of gene regulatory NETworks.

Paroni A, Graudenzi A, Caravagna G, Damiani C, Mauri G, Antoniotti M.

BMC Bioinformatics. 2016 Feb 4;17:64. doi: 10.1186/s12859-016-0914-z.


Incidental detection of familial APP duplication: an unusual reason for a false positive NIPT result of trisomy 21.

Meschino WS, Miller K, Bedford HM.

Prenat Diagn. 2016 Apr;36(4):382-4. doi: 10.1002/pd.4783. Epub 2016 Feb 24. No abstract available.


Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice.

Wang J, Li N, Ma J, Gu Z, Yu L, Fu X, Liu X, Wang J.

Brain Res. 2016 Mar 15;1635:169-79. doi: 10.1016/j.brainres.2016.01.028. Epub 2016 Jan 25.


Pharmacophore-based screening targeted at upregulated FN1, MMP-9, APP reveals therapeutic compounds for nasopharyngeal carcinoma.

Lai CJ, Tay BH.

Comput Biol Med. 2016 Feb 1;69:158-65. doi: 10.1016/j.compbiomed.2015.12.015. Epub 2015 Dec 31.


Electroacupuncture at the Baihui acupoint alleviates cognitive impairment and exerts neuroprotective effects by modulating the expression and processing of brain-derived neurotrophic factor in APP/PS1 transgenic mice.

Lin R, Chen J, Li X, Mao J, Wu Y, Zhuo P, Zhang Y, Liu W, Huang J, Tao J, Chen LD.

Mol Med Rep. 2016 Feb;13(2):1611-7. doi: 10.3892/mmr.2015.4751. Epub 2015 Dec 31.


Overexpression of Swedish mutant APP in aged astrocytes attenuates excitatory synaptic transmission.

Katsurabayashi S, Kawano H, Ii M, Nakano S, Tatsumi C, Kubota K, Takasaki K, Mishima K, Fujiwara M, Iwasaki K.

Physiol Rep. 2016 Jan;4(1). pii: e12665. doi: 10.14814/phy2.12665.


γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).

Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH.

PLoS One. 2015 Dec 17;10(12):e0144758. doi: 10.1371/journal.pone.0144758. eCollection 2015.


C6 Glioma-Secreted NGF and FGF2 Regulate Neuronal APP Processing Through Up-Regulation of ADAM10 and Down-Regulation of BACE1, Respectively.

Xie H, Xiao Z, Huang J.

J Mol Neurosci. 2016 Jul;59(3):334-42. doi: 10.1007/s12031-015-0690-7. Epub 2015 Nov 27.


Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS.

Rabinovich-Toidman P, Rabinovich-Nikitin I, Ezra A, Barbiro B, Fogel H, Slutsky I, Solomon B.

PLoS One. 2015 Nov 24;10(11):e0143420. doi: 10.1371/journal.pone.0143420. eCollection 2015.


Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.

Liao F, Zhang TJ, Jiang H, Lefton KB, Robinson GO, Vassar R, Sullivan PM, Holtzman DM.

Acta Neuropathol Commun. 2015 Nov 10;3:70. doi: 10.1186/s40478-015-0250-y.


Hippocampal Lipid Homeostasis in APP/PS1 Mice is Modulated by a Complex Interplay Between Dietary DHA and Estrogens: Relevance for Alzheimer's Disease.

Díaz M, Fabelo N, Casañas-Sánchez V, Marin R, Gómez T, Quinto-Alemany D, Pérez JA.

J Alzheimers Dis. 2016;49(2):459-81. doi: 10.3233/JAD-150470.


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