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Methods Find Exp Clin Pharmacol. 1994 Nov;16(9):677-83.

Augmentation of the immune response to influenza vaccine by acetylsalicylic acid: a clinical trial in a geriatric population.

Author information

1
Division of Cardiology, George Washington University, Washington, DC, USA.

Abstract

The purpose of this placebo-controlled, double-blind, randomized trial was to evaluate the efficacy of oral acetylsalicylic acid (ASA), a comparatively safe, inexpensive biological response modifier, as an adjuvant to influenza vaccination in a geriatric population. 281 healthy adults, 65 years or older, received influenza vaccine and were randomized to ASA or placebo. Serum antibody against influenza A/Beijing and B/Panama, influenza antigen-stimulated blastogenesis and antigen-stimulated interleukin-2 production by peripheral blood mononuclear cells in vitro were increased following vaccination. Blastogenic response and interleukin-2 production increased to a similar extent in the two treatment groups. The proportion of participants with a 4-fold rise in specific antibody directed against influenza A/Beijing was greater among ASA recipients (p < 0.05). This difference was more marked in subjects > 75 years old (p < 0.01).

PMID:
7746030
[Indexed for MEDLINE]

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