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Items: 1 to 20 of 4360

1.

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.

Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F.

Elife. 2018 Feb 20;7. pii: e31502. doi: 10.7554/eLife.31502.

PMID:
29460780
2.

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene.

Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Hnisz D, Li CH, Yuan B, Xu C, Li Y, Vershkov D, Cacace A, Young RA, Jaenisch R.

Cell. 2018 Feb 8. pii: S0092-8674(18)30049-7. doi: 10.1016/j.cell.2018.01.012. [Epub ahead of print]

PMID:
29456084
3.

Functional implications of inhibitory synapse placement on signal processing in pyramidal neuron dendrites.

Boivin JR, Nedivi E.

Curr Opin Neurobiol. 2018 Feb 15;51:16-22. doi: 10.1016/j.conb.2018.01.013. [Epub ahead of print] Review.

PMID:
29454834
4.

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs.

Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R.

Mol Cell. 2018 Feb 15;69(4):610-621.e5. doi: 10.1016/j.molcel.2018.01.024.

PMID:
29452640
5.

Activating Embryonic Development in Drosophila.

Avilés-Pagán EE, Orr-Weaver TL.

Semin Cell Dev Biol. 2018 Feb 12. pii: S1084-9521(17)30368-3. doi: 10.1016/j.semcdb.2018.02.019. [Epub ahead of print] Review.

PMID:
29448071
6.

Variant cell cycles regulated by Notch signaling control cell size and ensure a functional blood-brain barrier.

Von Stetina JR, Frawley LE, Unhavaithaya Y, Orr-Weaver TL.

Development. 2018 Feb 13;145(3). pii: dev157115. doi: 10.1242/dev.157115.

7.

Mechanical Protein Unfolding and Degradation.

Olivares AO, Baker TA, Sauer RT.

Annu Rev Physiol. 2018 Feb 10;80:413-429. doi: 10.1146/annurev-physiol-021317-121303.

PMID:
29433415
8.

Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP.

Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA.

Mol Cell. 2018 Feb 15;69(4):648-663.e7. doi: 10.1016/j.molcel.2018.01.006. Epub 2018 Feb 1.

PMID:
29398447
9.

Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis.

Phizicky DV, Berchowitz LE, Bell SP.

Elife. 2018 Feb 1;7. pii: e33309. doi: 10.7554/eLife.33309.

10.

Yeast-Based Synthetic Biology Platform for Antimicrobial Peptide Production.

Cao J, de la Fuente-Nunez C, Ou RW, Torres MT, Pande SG, Sinskey AJ, Lu TK.

ACS Synth Biol. 2018 Feb 12. doi: 10.1021/acssynbio.7b00396. [Epub ahead of print]

PMID:
29366323
11.

Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.

Calo E, Gu B, Bowen ME, Aryan F, Zalc A, Liang J, Flynn RA, Swigut T, Chang HY, Attardi LD, Wysocka J.

Nature. 2018 Feb 1;554(7690):112-117. doi: 10.1038/nature25449. Epub 2018 Jan 24.

PMID:
29364875
12.

Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon.

Ni TK, Elman JS, Jin DX, Gupta PB, Kuperwasser C.

Sci Rep. 2018 Jan 23;8(1):1415. doi: 10.1038/s41598-018-19916-8.

13.

The redox requirements of proliferating mammalian cells.

Hosios AM, Vander Heiden MG.

J Biol Chem. 2018 Jan 16. pii: jbc.TM117.000239. doi: 10.1074/jbc.TM117.000239. [Epub ahead of print]

14.

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.

Rezaei Araghi R, Bird GH, Ryan JA, Jenson JM, Godes M, Pritz JR, Grant RA, Letai A, Walensky LD, Keating AE.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E886-E895. doi: 10.1073/pnas.1712952115. Epub 2018 Jan 16.

PMID:
29339518
15.

Impact of oncogenic pathways on evasion of antitumour immune responses.

Spranger S, Gajewski TF.

Nat Rev Cancer. 2018 Jan 12. doi: 10.1038/nrc.2017.117. [Epub ahead of print] Review.

PMID:
29326431
16.

CRISPR-Cas9-based genome-wide screening of Toxoplasma gondii.

Sidik SM, Huet D, Lourido S.

Nat Protoc. 2018 Jan;13(1):307-323. doi: 10.1038/nprot.2017.131. Epub 2018 Jan 11.

PMID:
29323662
17.

Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation.

Roper J, Tammela T, Akkad A, Almeqdadi M, Santos SB, Jacks T, Yilmaz ÖH.

Nat Protoc. 2018 Feb;13(2):217-234. doi: 10.1038/nprot.2017.136. Epub 2018 Jan 4.

PMID:
29300388
18.

Predicting the future of signaling for 2018.

Yaffe MB.

Sci Signal. 2018 Jan 2;11(511). pii: eaar7429. doi: 10.1126/scisignal.aar7429.

PMID:
29295956
19.

TAZ/WWTR1 mediates the pulmonary effects of NKX2-1 mutations in Brain-Lung-Thyroid syndrome.

Moya CM, Zaballos MA, Garzón L, Luna C, Simón R, Yaffe MB, Gallego E, Santisteban P, Moreno JC.

J Clin Endocrinol Metab. 2017 Dec 26. doi: 10.1210/jc.2017-01241. [Epub ahead of print]

PMID:
29294041
20.

The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture.

Pai AA, Henriques T, McCue K, Burkholder A, Adelman K, Burge CB.

Elife. 2017 Dec 27;6. pii: e32537. doi: 10.7554/eLife.32537.

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