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Presse Med. 1999 Jul 3-10;28(24):1290-2.

[Acute transverse cervical myelitis following hepatitis B vaccination. Evolution of anti-HBs antibodies].

[Article in French]

Author information

1
Clinique de neurologie, HIA Val-de-GrĂ¢ce, Paris.

Abstract

BACKGROUND:

The cause and effect relationship between anti-HBV immunization using recombinant vaccine and the development of a neurological event, including flare-ups of multiple sclerosis, is a widely debated issue.

CASE REPORT:

A previously asymptomatic 16-year-old girl was a hyper-responder to anti-HBV vaccine. Subsequent to a booster shot of anti-HBV recombinant vaccine, she developed regressive acute cervical transverse myelitis with intrathecal oligochonal IgG secretion and a hypersignal on the MRI T2 sequences of the cord.

DISCUSSION:

The distinction between a first episode of multiple sclerosis or post-vaccinal acute myelitis in this case will depend upon subsequent course, but this observation points out the very high level of persistent post-vaccinal immunization which can be acquired by a hyper-responder.

PMID:
10442059
[Indexed for MEDLINE]

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