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Oncotarget. 2016 Apr 12;7(15):20743-52. doi: 10.18632/oncotarget.7868.

The preclinical study of predicting radiosensitivity in human nasopharyngeal carcinoma xenografts by 18F-ML-10 animal- PET/CT imaging.

Bao X1,2,3,4, Yang Z1,2,3,4, Wang S1,2,3,4, Zheng Y1,2,3,4, Wang M1,2,3,4, Gu B1,2,3,4, Zhang J1,2,3,4, Zhang Y1,2,3,4, Zhang Y1,2,3,4.

Author information

  • 1Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
  • 3Center for Biomedical Imaging, Fudan University, Shanghai 200032, China.
  • 4Shanghai Engineering Research Center for Molecular Imaging Probes, Shanghai 200032, China.

Abstract

Previous studies have reported that the radiosensitivity is associated with apoptosis. Hereby, we aimed to investigate the value of 18F-ML-10 PET/CT, which selectively targeted cells undergoing apoptosis, in predicting radiosensitivity of human nasopharyngeal carcinoma (NPC) xenografts. We used CNE1 (highly differentiated) and CNE2 (poorly differentiated) NPC cell lines to construct tumor models, which had very different radiosensitivities. After irradiation, the volumes of CNE2 tumors decreased significantly while those of CNE1 tumors increased. In 18F-ML-10 imaging, the values of tumor/muscle (T/M) between CNE1 and CNE2 mice were statistically different at both 24 h and 48 h after irradiation. Besides, ΔT/M1-0 and ΔT/M2-0 of CNE2 mice were higher than those of CNE1 mice, demonstrating obvious discrepancy. Furthermore, we observed obvious changes of radioactive distribution in CNE2 group. On the contrary, T/M of 18F-FDG in irradiation group revealed no obvious change in both CNE1 and CNE2 groups. In conclusion, 18F-ML-10 animal PET/CT showed its potential to predict radiosensitivity in NPC.

KEYWORDS:

18F-ML-10; animal-PET/CT; irradiation sensitivity; nasopharyngeal carcinoma; nude mouse

PMID:
26942701
PMCID:
PMC4991489
DOI:
10.18632/oncotarget.7868
[PubMed - in process]
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