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Items: 1 to 20 of 229

1.

Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase.

McBrayer SK, Olenchock BA, DiNatale GJ, Shi DD, Khanal J, Jennings RB, Novak JS, Oser MG, Robbins AK, Modiste R, Bonal D, Moslehi J, Bronson RT, Neuberg D, Nguyen QD, Signoretti S, Losman JA, Kaelin WG Jr.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3741-E3748. doi: 10.1073/pnas.1716029115. Epub 2018 Apr 2.

PMID:
29610306
2.

HIF2 Inhibitor Joins the Kidney Cancer Armamentarium.

Kaelin WG Jr.

J Clin Oncol. 2018 Mar 20;36(9):908-910. doi: 10.1200/JCO.2017.77.5254. Epub 2018 Jan 31. No abstract available.

PMID:
29384723
3.

Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma.

Miao D, Margolis CA, Gao W, Voss MH, Li W, Martini DJ, Norton C, Bossé D, Wankowicz SM, Cullen D, Horak C, Wind-Rotolo M, Tracy A, Giannakis M, Hodi FS, Drake CG, Ball MW, Allaf ME, Snyder A, Hellmann MD, Ho T, Motzer RJ, Signoretti S, Kaelin WG Jr, Choueiri TK, Van Allen EM.

Science. 2018 Feb 16;359(6377):801-806. doi: 10.1126/science.aan5951. Epub 2018 Jan 4.

4.

Senator McCain and Our Shared Humanity.

Kaelin WG Jr.

Am J Med. 2018 Mar;131(3):216-217. doi: 10.1016/j.amjmed.2017.11.028. Epub 2017 Dec 8. No abstract available.

PMID:
29229468
5.

Climate Change: What Would Lincoln Do?

Kaelin WG Jr.

JAMA. 2017 Aug 15;318(7):611. doi: 10.1001/jama.2017.6999. No abstract available.

PMID:
28810027
6.

The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.

Kaelin WG Jr.

Trans Am Clin Climatol Assoc. 2017;128:298-307. Review.

7.

HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.

Chakraborty AA, Nakamura E, Qi J, Creech A, Jaffe JD, Paulk J, Novak JS, Nagulapalli K, McBrayer SK, Cowley GS, Pineda J, Song J, Wang YE, Carr SA, Root DE, Signoretti S, Bradner JE, Kaelin WG Jr.

Sci Transl Med. 2017 Jul 12;9(398). pii: eaal5272. doi: 10.1126/scitranslmed.aal5272.

8.

The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks.

Ivan M, Kaelin WG Jr.

Mol Cell. 2017 Jun 15;66(6):772-779. doi: 10.1016/j.molcel.2017.06.002. Review.

9.

Publish houses of brick, not mansions of straw.

Kaelin WG Jr.

Nature. 2017 May 23;545(7655):387. doi: 10.1038/545387a. No abstract available.

PMID:
28541345
10.

Common pitfalls in preclinical cancer target validation.

Kaelin WG Jr.

Nat Rev Cancer. 2017 Jul;17(7):425-440. doi: 10.1038/nrc.2017.32. Epub 2017 May 19.

PMID:
28524181
11.

Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma.

Gao W, Li W, Xiao T, Liu XS, Kaelin WG Jr.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1027-1032. doi: 10.1073/pnas.1619726114. Epub 2017 Jan 12.

12.

Targeting HIF2 in Clear Cell Renal Cell Carcinoma.

Cho H, Kaelin WG.

Cold Spring Harb Symp Quant Biol. 2016;81:113-121. doi: 10.1101/sqb.2016.81.030833. Epub 2016 Dec 8. Review.

PMID:
27932568
13.

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.

Cho H, Du X, Rizzi JP, Liberzon E, Chakraborty AA, Gao W, Carvo I, Signoretti S, Bruick RK, Josey JA, Wallace EM, Kaelin WG.

Nature. 2016 Nov 3;539(7627):107-111. doi: 10.1038/nature19795. Epub 2016 Sep 5.

14.

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC.

Mol Cell. 2016 Sep 15;63(6):1006-20. doi: 10.1016/j.molcel.2016.08.014.

15.

Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award.

Kaelin WG Jr, Ratcliffe PJ, Semenza GL.

JAMA. 2016 Sep 27;316(12):1252-3. doi: 10.1001/jama.2016.12386. No abstract available.

PMID:
27622845
16.

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.

Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG Jr, Wei W.

Science. 2016 Aug 26;353(6302):929-32. doi: 10.1126/science.aad5755.

17.

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Briggs KJ, Koivunen P, Cao S, Backus KM, Olenchock BA, Patel H, Zhang Q, Signoretti S, Gerfen GJ, Richardson AL, Witkiewicz AK, Cravatt BF, Clardy J, Kaelin WG Jr.

Cell. 2016 Jun 30;166(1):126-39. doi: 10.1016/j.cell.2016.05.042.

18.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Apr 7;165(2):497. doi: 10.1016/j.cell.2016.03.037. No abstract available.

19.

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Olenchock BA, Moslehi J, Baik AH, Davidson SM, Williams J, Gibson WJ, Chakraborty AA, Pierce KA, Miller CM, Hanse EA, Kelekar A, Sullivan LB, Wagers AJ, Clish CB, Vander Heiden MG, Kaelin WG Jr.

Cell. 2016 Feb 25;164(5):884-95. doi: 10.1016/j.cell.2016.02.006. Erratum in: Cell. 2016 Apr 7;165(2):497.

20.

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.

Laukka T, Mariani CJ, Ihantola T, Cao JZ, Hokkanen J, Kaelin WG Jr, Godley LA, Koivunen P.

J Biol Chem. 2016 Feb 19;291(8):4256-65. doi: 10.1074/jbc.M115.688762. Epub 2015 Dec 23.

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