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Items: 1 to 20 of 81


Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation.

Aromolaran AS, Srivastava U, Alí A, Chahine M, Lazaro D, El-Sherif N, Capecchi PL, Laghi-Pasini F, Lazzerini PE, Boutjdir M.

PLoS One. 2018 Dec 6;13(12):e0208321. doi: 10.1371/journal.pone.0208321. eCollection 2018.


A204E mutation in Nav1.4 DIS3 exerts gain- and loss-of-function effects that lead to periodic paralysis combining hyper- with hypo-kalaemic signs.

Kokunai Y, Dalle C, Vicart S, Sternberg D, Pouliot V, Bendahhou S, Fournier E, Chahine M, Fontaine B, Nicole S.

Sci Rep. 2018 Nov 12;8(1):16681. doi: 10.1038/s41598-018-34750-8.


A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Nav1.5 Gating Pores.

Moreau A, Chahine M.

Front Cardiovasc Med. 2018 Oct 9;5:139. doi: 10.3389/fcvm.2018.00139. eCollection 2018. Review.


A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy.

Moreau A, Gosselin-Badaroudine P, Mercier A, Burger B, Keller DI, Chahine M.

Sci Rep. 2018 Sep 14;8(1):13804. doi: 10.1038/s41598-018-31772-0.


Improving the characterization of calcium channel gating pore currents with Stac3.

Chahine M.

J Gen Physiol. 2018 Feb 21. pii: jgp.201711984. doi: 10.1085/jgp.201711984. [Epub ahead of print] No abstract available.


Substitutions of the S4DIV R2 residue (R1451) in NaV1.4 lead to complex forms of paramyotonia congenita and periodic paralyses.

Poulin H, Gosselin-Badaroudine P, Vicart S, Habbout K, Sternberg D, Giuliano S, Fontaine B, Bendahhou S, Nicole S, Chahine M.

Sci Rep. 2018 Feb 1;8(1):2041. doi: 10.1038/s41598-018-20468-0.


Mechanisms of Drug Binding to Voltage-Gated Sodium Channels.

O'Leary ME, Chahine M.

Handb Exp Pharmacol. 2018;246:209-231. doi: 10.1007/164_2017_73. Review.


Metaflumizone inhibits the honeybee NaV 1 channel by targeting recovery from slow inactivation.

Gosselin-Badaroudine P, Charnet P, Collet C, Chahine M.

FEBS Lett. 2017 Dec;591(23):3842-3849. doi: 10.1002/1873-3468.12897. Epub 2017 Nov 12.


Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C.

Aromolaran AS, Chahine M, Boutjdir M.

Handb Exp Pharmacol. 2018;246:161-184. doi: 10.1007/164_2017_53. Review.


Biophysical characterization of the Varroa destructor NaV1 sodium channel and its affinity for τ-fluvalinate insecticide.

Gosselin-Badaroudine P, Chahine M.

FASEB J. 2017 Jul;31(7):3066-3071. doi: 10.1096/fj.201601338R. Epub 2017 Mar 29.


Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges.

Moreau A, Boutjdir M, Chahine M.

Can J Physiol Pharmacol. 2017 Oct;95(10):1108-1116. doi: 10.1139/cjpp-2016-0726. Epub 2017 Mar 28. Review.


Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Moreau A, Mercier A, Thériault O, Boutjdir M, Burger B, Keller DI, Chahine M.

Can J Cardiol. 2017 Feb;33(2):269-278. doi: 10.1016/j.cjca.2016.10.001. Epub 2016 Oct 11.


Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea-pigs.

Fabris F, Yue Y, Qu Y, Chahine M, Sobie E, Lee P, Wieczorek R, Jiang XC, Capecchi PL, Laghi-Pasini F, Lazzerini PE, Boutjdir M.

J Physiol. 2016 Nov 1;594(21):6175-6187. doi: 10.1113/JP272151. Epub 2016 Jul 26.


Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4.

Gosselin-Badaroudine P, Moreau A, Simard L, Cens T, Rousset M, Collet C, Charnet P, Chahine M.

J Gen Physiol. 2016 Aug;148(2):133-45. doi: 10.1085/jgp.201611614. Epub 2016 Jul 18.


Editorial: Recent Advances in Voltage-Gated Sodium Channels, their Pharmacology and Related Diseases.

Chahine M, Desaphy JF.

Front Pharmacol. 2016 Feb 8;7:20. doi: 10.3389/fphar.2016.00020. eCollection 2016. No abstract available.


Mutations in the Voltage Sensors of Domains I and II of Nav1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents.

Moreau A, Gosselin-Badaroudine P, Boutjdir M, Chahine M.

Front Pharmacol. 2015 Dec 24;6:301. doi: 10.3389/fphar.2015.00301. eCollection 2015.


A recessive Nav1.4 mutation underlies congenital myasthenic syndrome with periodic paralysis.

Habbout K, Poulin H, Rivier F, Giuliano S, Sternberg D, Fontaine B, Eymard B, Morales RJ, Echenne B, King L, Hanna MG, Männikkö R, Chahine M, Nicole S, Bendahhou S.

Neurology. 2016 Jan 12;86(2):161-9. doi: 10.1212/WNL.0000000000002264. Epub 2015 Dec 11.


[Omega pore, an alternative ion channel permeation pathway involved in the development of several channelopathies].

Moreau A, Chahine M.

Med Sci (Paris). 2015 Aug-Sep;31(8-9):735-41. doi: 10.1051/medsci/20153108011. Epub 2015 Sep 4. Review. French.


Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides.

Gosselin-Badaroudine P, Moreau A, Delemotte L, Cens T, Collet C, Rousset M, Charnet P, Klein ML, Chahine M.

Sci Rep. 2015 Jul 23;5:12475. doi: 10.1038/srep12475.


Differential modulation of Nav1.7 and Nav1.8 channels by antidepressant drugs.

Thériault O, Poulin H, Beaulieu JM, Chahine M.

Eur J Pharmacol. 2015 Oct 5;764:395-403. doi: 10.1016/j.ejphar.2015.06.053. Epub 2015 Jul 14.


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