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Items: 1 to 20 of 41


Structural basis for nucleotide-modulated p97 association with the ER membrane.

Tang WK, Zhang T, Ye Y, Xia D.

Cell Discov. 2017 Dec 12;3:17045. doi: 10.1038/celldisc.2017.45. eCollection 2017.


A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.

Ye Y, Tang WK, Zhang T, Xia D.

Front Mol Biosci. 2017 Jun 13;4:39. doi: 10.3389/fmolb.2017.00039. eCollection 2017. Review.


Mutations in the Human AAA+ Chaperone p97 and Related Diseases.

Tang WK, Xia D.

Front Mol Biosci. 2016 Dec 1;3:79. eCollection 2016. Review.


Hydrogen Bonding to the Substrate Is Not Required for Rieske Iron-Sulfur Protein Docking to the Quinol Oxidation Site of Complex III.

Esser L, Zhou F, Zhou Y, Xiao Y, Tang WK, Yu CA, Qin Z, Xia D.

J Biol Chem. 2016 Nov 25;291(48):25019-25031. Epub 2016 Oct 7.


Off-pathway assembly of fimbria subunits is prevented by chaperone CfaA of CFA/I fimbriae from enterotoxigenic E. coli.

Bao R, Liu Y, Savarino SJ, Xia D.

Mol Microbiol. 2016 Dec;102(6):975-991. doi: 10.1111/mmi.13530. Epub 2016 Oct 7.


Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein.

Esser L, Shukla S, Zhou F, Ambudkar SV, Xia D.

Acta Crystallogr F Struct Biol Commun. 2016 Aug;72(Pt 8):636-41. doi: 10.1107/S2053230X16009778. Epub 2016 Jul 27.


Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.

Frank GA, Shukla S, Rao P, Borgnia MJ, Bartesaghi A, Merk A, Mobin A, Esser L, Earl LA, Gottesman MM, Xia D, Ambudkar SV, Subramaniam S.

Mol Pharmacol. 2016 Jul;90(1):35-41. doi: 10.1124/mol.116.104190. Epub 2016 May 11.


Structure and function of the AAA+ ATPase p97/Cdc48p.

Xia D, Tang WK, Ye Y.

Gene. 2016 May 25;583(1):64-77. doi: 10.1016/j.gene.2016.02.042. Epub 2016 Mar 3. Review.


Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

Pluchino KM, Hall MD, Moen JK, Chufan EE, Fetsch PA, Shukla S, Gill DR, Hyde SC, Xia D, Ambudkar SV, Gottesman MM.

Biochemistry. 2016 Feb 23;55(7):1010-23. doi: 10.1021/acs.biochem.5b01064. Epub 2016 Feb 10.


In Search of a Cure for Proteostasis-Addicted Cancer: A AAA Target Revealed.

Xia D, Ye Y.

Cancer Cell. 2015 Nov 9;28(5):550-552. doi: 10.1016/j.ccell.2015.10.006.


Molecular Basis for Cooperative Binding of Anionic Phospholipids to the PH Domain of the Arf GAP ASAP1.

Jian X, Tang WK, Zhai P, Roy NS, Luo R, Gruschus JM, Yohe ME, Chen PW, Li Y, Byrd RA, Xia D, Randazzo PA.

Structure. 2015 Nov 3;23(11):1977-88. doi: 10.1016/j.str.2015.08.008. Epub 2015 Sep 10.


Structure of CfaA suggests a new family of chaperones essential for assembly of class 5 fimbriae.

Bao R, Fordyce A, Chen YX, McVeigh A, Savarino SJ, Xia D.

PLoS Pathog. 2014 Aug 14;10(8):e1004316. doi: 10.1371/journal.ppat.1004316. eCollection 2014 Aug.


Studies on inhibition of respiratory cytochrome bc1 complex by the fungicide pyrimorph suggest a novel inhibitory mechanism.

Xiao YM, Esser L, Zhou F, Li C, Zhou YH, Yu CA, Qin ZH, Xia D.

PLoS One. 2014 Apr 3;9(4):e93765. doi: 10.1371/journal.pone.0093765. eCollection 2014.


Preliminary X-ray diffraction analysis of CfaA, a molecular chaperone essential for the assembly of CFA/I fimbriae of human enterotoxigenic Escherichia coli.

Bao R, Esser L, Poole S, McVeigh A, Chen YX, Savarino SJ, Xia D.

Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):196-9. doi: 10.1107/S2053230X13033967. Epub 2014 Jan 21.


Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6 antigen (Psa) fimbriae of Yersinia pestis.

Bao R, Nair MK, Tang WK, Esser L, Sadhukhan A, Holland RL, Xia D, Schifferli DM.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1065-70. doi: 10.1073/pnas.1212431110. Epub 2012 Dec 31.


Structural analysis of cytochrome bc1 complexes: implications to the mechanism of function.

Xia D, Esser L, Tang WK, Zhou F, Zhou Y, Yu L, Yu CA.

Biochim Biophys Acta. 2013 Nov-Dec;1827(11-12):1278-94. doi: 10.1016/j.bbabio.2012.11.008. Epub 2012 Nov 29. Review.


Crystallization and preliminary X-ray diffraction analysis of PsaA, the adhesive pilin subunit that forms the pH 6 antigen on the surface of Yersinia pestis.

Bao R, Esser L, Sadhukhan A, Nair MK, Schifferli DM, Xia D.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1243-6. doi: 10.1107/S1744309112033076. Epub 2012 Sep 29.


Structural and functional deviations in disease-associated p97 mutants.

Tang WK, Xia D.

J Struct Biol. 2012 Aug;179(2):83-92. doi: 10.1016/j.jsb.2012.04.024. Epub 2012 May 8. Review.


Toward understanding the mechanism of action of the yeast multidrug resistance transporter Pdr5p: a molecular modeling study.

Rutledge RM, Esser L, Ma J, Xia D.

J Struct Biol. 2011 Feb;173(2):333-44. doi: 10.1016/j.jsb.2010.10.012. Epub 2010 Oct 27.

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