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Zafirlukast.
[No authors listed] [No authors listed] 2019 Jun 4. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2019 Jun 4. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643251 Free Books & Documents. Review.
Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma. Zafirlukast has been linked to rare, but occasionally severe cases of acute liver injury....
Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of …
Cysteinyl Leukotriene Pathway and Cancer.
Tsai MJ, Chang WA, Chuang CH, Wu KL, Cheng CH, Sheu CC, Hsu YL, Hung JY. Tsai MJ, et al. Int J Mol Sci. 2021 Dec 23;23(1):120. doi: 10.3390/ijms23010120. Int J Mol Sci. 2021. PMID: 35008546 Free PMC article. Review.
A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC).
Figueroa EE, Denton JS. Figueroa EE, et al. Channels (Austin). 2022 Dec;16(1):27-36. doi: 10.1080/19336950.2022.2033511. Channels (Austin). 2022. PMID: 35114895 Free PMC article. Review.
We discuss the discovery and characterization of cysteinyl leukotriene receptor antagonists Pranlukast and Zafirlukast as novel VRAC inhibitors, and zinc pyrithione (ZPT), which apparently activates VRAC through a reactive oxygen species (ROS)-dependent mechanism. ...
We discuss the discovery and characterization of cysteinyl leukotriene receptor antagonists Pranlukast and Zafirlukast as novel VRAC …