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Synthesis and structure-activity relationships of teixobactin.
Karas JA, Chen F, Schneider-Futschik EK, Kang Z, Hussein M, Swarbrick J, Hoyer D, Giltrap AM, Payne RJ, Li J, Velkov T. Karas JA, et al. Ann N Y Acad Sci. 2020 Jan;1459(1):86-105. doi: 10.1111/nyas.14282. Epub 2019 Dec 2. Ann N Y Acad Sci. 2020. PMID: 31792983 Review.
One of the key features of teixobactin as an antibiotic lead is that resistance could not be generated in a laboratory setting. ...Teixobactin represents an exciting starting point for the development of new antibiotics that can be used to combat multidrug-resistant …
One of the key features of teixobactin as an antibiotic lead is that resistance could not be generated in a laboratory setting. ... …
Discovery, synthesis, and optimization of teixobactin, a novel antibiotic without detectable bacterial resistance.
Qi YK, Tang X, Wei NN, Pang CJ, Du SS, Wang K. Qi YK, et al. J Pept Sci. 2022 Nov;28(11):e3428. doi: 10.1002/psc.3428. Epub 2022 Jun 13. J Pept Sci. 2022. PMID: 35610021 Review.
The synthetic methods for the key building block l-allo-End, natural teixobactin, representative teixobactin analogs, as well as the structure-activity relationship studies will be highlighted and discussed in details. Finally, some insights into new trends for the …
The synthetic methods for the key building block l-allo-End, natural teixobactin, representative teixobactin analogs, as well …
At the Crossroads of Bioenergetics and Antibiotic Discovery.
Lewis K. Lewis K. Biochemistry (Mosc). 2020 Dec;85(12):1469-1483. doi: 10.1134/S0006297920120019. Biochemistry (Mosc). 2020. PMID: 33705287 Free article. Review.
Searching for compounds that can corrupt targets in the absence of ATP, we identified acyldepsipeptide (ADEP) that activates the ClpP protease, forcing cells to self-digest. Growing previously uncultured bacteria led us to teixobactin, a novel cell wall acting antibiotic. …
Searching for compounds that can corrupt targets in the absence of ATP, we identified acyldepsipeptide (ADEP) that activates the ClpP protea …
Engineering lanthipeptides by introducing a large variety of RiPP modifications to obtain new-to-nature bioactive peptides.
Fu Y, Xu Y, Ruijne F, Kuipers OP. Fu Y, et al. FEMS Microbiol Rev. 2023 May 19;47(3):fuad017. doi: 10.1093/femsre/fuad017. FEMS Microbiol Rev. 2023. PMID: 37096385 Free PMC article. Review.
We highlight the prospect of lanthipeptide- and RiPP-engineering to produce and screen novel peptides, including mimics of potent non-ribosomally produced antimicrobial peptides (NRPs) such as daptomycin, vancomycin, and teixobactin, which offer high therapeutic potential. …
We highlight the prospect of lanthipeptide- and RiPP-engineering to produce and screen novel peptides, including mimics of potent non-riboso …
Spotlight on the Selected New Antimicrobial Innate Immune Peptides Discovered During 2015-2019.
Dang X, Wang G. Dang X, et al. Curr Top Med Chem. 2020;20(32):2984-2998. doi: 10.2174/1568026620666201022143625. Curr Top Med Chem. 2020. PMID: 33092508 Free PMC article. Review.
RESULTS: This article highlights a selected set of new AMP members with interesting properties. Teixobactin is a cell wall inhibiting peptide antibiotic, while darobactin inhibits a chaperone and translocator for outer membrane proteins. ...
RESULTS: This article highlights a selected set of new AMP members with interesting properties. Teixobactin is a cell wall inhibiting …