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A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC).
Figueroa EE, Denton JS. Figueroa EE, et al. Channels (Austin). 2022 Dec;16(1):27-36. doi: 10.1080/19336950.2022.2033511. Channels (Austin). 2022. PMID: 35114895 Free PMC article. Review.
We discuss the discovery and characterization of cysteinyl leukotriene receptor antagonists Pranlukast and Zafirlukast as novel VRAC inhibitors, and zinc pyrithione (ZPT), which apparently activates VRAC through a reactive oxygen species (ROS)-dependent mechanism. ...
We discuss the discovery and characterization of cysteinyl leukotriene receptor antagonists Pranlukast and Zafirlukast as novel VRAC …