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2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery.
Bender AM, Parr LC, Livingston WB, Lindsley CW, Merryman WD. Bender AM, et al. J Med Chem. 2023 Aug 24;66(16):11027-11039. doi: 10.1021/acs.jmedchem.3c01178. Epub 2023 Aug 16. J Med Chem. 2023. PMID: 37584406 Review.
The cardiotoxicity associated with des-ethyl-dexfenfluramine (norDF) and related agonists of the serotonin receptor 2B (5-HT(2B)) has solidified the receptor's place as an "antitarget" in drug discovery. ...
The cardiotoxicity associated with des-ethyl-dexfenfluramine (norDF) and related agonists of the serotonin receptor 2B (5-HT(2B)) has …
Fluoxetine for adults who are overweight or obese.
Serralde-Zúñiga AE, Gonzalez Garay AG, Rodríguez-Carmona Y, Melendez G. Serralde-Zúñiga AE, et al. Cochrane Database Syst Rev. 2019 Oct 15;10(10):CD011688. doi: 10.1002/14651858.CD011688.pub2. Cochrane Database Syst Rev. 2019. PMID: 31613390 Free PMC article. Review.
A total of 2216 participants entered the trials, 1280 participants were randomly assigned to fluoxetine (60 mg/d, 40 mg/d, 20 mg/d and 10 mg/d) and 936 participants were randomly assigned to various comparison groups (placebo; the anti-obesity agents diethylpropion, fenproporex, …
A total of 2216 participants entered the trials, 1280 participants were randomly assigned to fluoxetine (60 mg/d, 40 mg/d, 20 mg/d and 10 mg …
Interventions for preventing weight gain after smoking cessation.
Hartmann-Boyce J, Theodoulou A, Farley A, Hajek P, Lycett D, Jones LL, Kudlek L, Heath L, Hajizadeh A, Schenkels M, Aveyard P. Hartmann-Boyce J, et al. Cochrane Database Syst Rev. 2021 Oct 6;10(10):CD006219. doi: 10.1002/14651858.CD006219.pub4. Cochrane Database Syst Rev. 2021. PMID: 34611902 Free PMC article. Review.
Some pharmacological interventions tested for limiting post-cessation weight gain (PCWG) reduced weight gain at the end of treatment (dexfenfluramine, phenylpropanolamine, naltrexone). The effects of ephedrine and caffeine combined, lorcaserin, and chromium were too imprec …
Some pharmacological interventions tested for limiting post-cessation weight gain (PCWG) reduced weight gain at the end of treatment (dex …