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1993 2
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2023 14
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Page 1
Pharmacological Treatment of Tremor in Parkinson's Disease Revisited.
Pirker W, Katzenschlager R, Hallett M, Poewe W. Pirker W, et al. J Parkinsons Dis. 2023;13(2):127-144. doi: 10.3233/JPD-225060. J Parkinsons Dis. 2023. PMID: 36847017 Free PMC article. Review.
Treating motor fluctuations with MAO-B and COMT inhibitors, dopamine agonists, amantadine, or on-demand treatments such as subcutaneous or sublingual apomorphine and inhaled levodopa as well as with continuous infusions of levodopa or apomorphine will improve off pe …
Treating motor fluctuations with MAO-B and COMT inhibitors, dopamine agonists, amantadine, or on-demand treatments such as subcutaneous or s …
Off-time Treatment Options for Parkinson's Disease.
Fabbri M, Barbosa R, Rascol O. Fabbri M, et al. Neurol Ther. 2023 Apr;12(2):391-424. doi: 10.1007/s40120-022-00435-8. Epub 2023 Jan 12. Neurol Ther. 2023. PMID: 36633762 Free PMC article. Review.
The armamentarium of first-line treatment options has widened in the last decade with new once-a-daily compounds, including a catechol O-methyltransferase inhibitor - Opicapone-, two MAO-B inhibitors plus channel blocker - Zonisamide and Safinamide and one amantadine extended-rel …
The armamentarium of first-line treatment options has widened in the last decade with new once-a-daily compounds, including a catechol O-met …
Apomorphine.
[No authors listed] [No authors listed] 2022 Jul 18. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2022 Jul 18. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30835406 Free Books & Documents. Review.
No information is available on the use of apomorphine during breastfeeding. If apomorphine is required by the mother, it is not a reason to discontinue breastfeeding. However, apomorphine inhibits prolactin release in animals and might interfere with establis …
No information is available on the use of apomorphine during breastfeeding. If apomorphine is required by the mother, it is no …
VPS35-Related Parkinson Disease.
Dulski J, Ross OA, Wszolek ZK. Dulski J, et al. 2017 Aug 10 [updated 2023 Mar 23]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2017 Aug 10 [updated 2023 Mar 23]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 28796472 Free Books & Documents. Review.
In addition, in those with dyskinesia and motor fluctuations, subthalamic deep brain stimulation and apomorphine intermittent injections or continuous therapy with an infusion pump should be considered. ...
In addition, in those with dyskinesia and motor fluctuations, subthalamic deep brain stimulation and apomorphine intermittent injecti …
Parkinson Disease Agents.
[No authors listed] [No authors listed] 2021 Oct 25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2021 Oct 25. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31644162 Free Books & Documents. Review.
Dopamine receptor agonists currently available include bromocriptine (1978: Parlodel), pergolide (Permax: 1988), apomorphine (Apokyn: 2004) and more selective agonists for the D2 class of dopamine receptors - ropinirole (Requip: 1997), pramipexole (Mirapex: 1997) and rotig …
Dopamine receptor agonists currently available include bromocriptine (1978: Parlodel), pergolide (Permax: 1988), apomorphine (Apokyn: …
Current and novel infusion therapies for patients with Parkinson's disease.
Antonini A, D'Onofrio V, Guerra A. Antonini A, et al. J Neural Transm (Vienna). 2023 Nov;130(11):1349-1358. doi: 10.1007/s00702-023-02693-8. Epub 2023 Sep 6. J Neural Transm (Vienna). 2023. PMID: 37672049 Free PMC article. Review.
The implementation of drug delivery systems allows to bypass problems related to irregular and often unpredictable intestinal absorption of oral levodopa, which significantly affects its bioavailability and contributes to the development and persistence of motor complications. Su …
The implementation of drug delivery systems allows to bypass problems related to irregular and often unpredictable intestinal absorption of …
Drugs to the Rescue: Comparison of On-Demand Therapies for OFF Symptoms in Parkinson's Disease.
Martinez-Nunez AE, LeWitt PA. Martinez-Nunez AE, et al. J Parkinsons Dis. 2023;13(4):441-451. doi: 10.3233/JPD-230055. J Parkinsons Dis. 2023. PMID: 37182902 Free PMC article. Review.
This review focuses on a group of drugs that have the pharmacokinetic advantage of a much earlier onset of action by virtue of their non-oral routes of absorption. We compare the current marketed options: subcutaneous apomorphine, sublingual apomorphine, and inhaled …
This review focuses on a group of drugs that have the pharmacokinetic advantage of a much earlier onset of action by virtue of their non-ora …
Infusion Therapies in the Treatment of Parkinson's Disease.
van Laar T, Chaudhuri KR, Antonini A, Henriksen T, Trošt M. van Laar T, et al. J Parkinsons Dis. 2023;13(5):641-657. doi: 10.3233/JPD-225112. J Parkinsons Dis. 2023. PMID: 37334617 Free PMC article. Review.
Patients in this advanced PD stage may benefit from alternative therapy, such as continuous intrajejunal delivery of levodopa-carbidopa intestinal gel (LCIG; or carbidopa-levodopa enteral suspension), continuous intrajejunal delivery of levodopa-carbidopa-entacapone intestinal ge …
Patients in this advanced PD stage may benefit from alternative therapy, such as continuous intrajejunal delivery of levodopa-carbidopa inte …
Apomorphine for Parkinson's Disease: Efficacy and Safety of Current and New Formulations.
Carbone F, Djamshidian A, Seppi K, Poewe W. Carbone F, et al. CNS Drugs. 2019 Sep;33(9):905-918. doi: 10.1007/s40263-019-00661-z. CNS Drugs. 2019. PMID: 31473980 Free PMC article. Review.
Clinical trials have shown that intermittent apomorphine injections provide rapid and effective relief from unpredictable "off" periods. Continuous apomorphine infusion reduced around 50% of the daily "off" time in several studies. ...
Clinical trials have shown that intermittent apomorphine injections provide rapid and effective relief from unpredictable "off" perio …
Adopting the Rumsfeld approach to understanding the action of levodopa and apomorphine in Parkinson's disease.
Jenner P, Falup-Pecurariu C, Leta V, Verin M, Auffret M, Bhidayasiri R, Weiss D, Borovečki F, Jost WH. Jenner P, et al. J Neural Transm (Vienna). 2023 Nov;130(11):1337-1347. doi: 10.1007/s00702-023-02655-0. Epub 2023 May 20. J Neural Transm (Vienna). 2023. PMID: 37210460 Free PMC article. Review.
Two of the oldest drugs used appear more effective than others-levodopa and apomorphine-but the reasons for this are seldom discussed and this may be one cause for a lack of progress. This short review questions current thinking on drug action and looks at whether adopting …
Two of the oldest drugs used appear more effective than others-levodopa and apomorphine-but the reasons for this are seldom discussed …
42 results