Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2014 1
2015 4
2016 4
2017 1
2018 1
2019 1
2020 7
2021 11
2022 4
2023 5
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

33 results

Results by year

Filters applied: . Clear all
Page 1
Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.
Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S. Elgendy M, et al. Cancer Cell. 2019 May 13;35(5):798-815.e5. doi: 10.1016/j.ccell.2019.03.007. Epub 2019 Apr 25. Cancer Cell. 2019. PMID: 31031016 Free article.
Synergistic anti-neoplastic effects of the metformin/hypoglycemia combination were mediated by glycogen synthase kinase 3beta (GSK3beta) activation downstream of PP2A, leading to a decline in the pro-survival protein MCL-1, and cell death. Mechanistically, specific activat …
Synergistic anti-neoplastic effects of the metformin/hypoglycemia combination were mediated by glycogen synthase kinase 3beta (GSK3beta) act …
PPP2R5D-Related Intellectual Disability and Neurodevelopmental Delay: A Review of the Current Understanding of the Genetics and Biochemical Basis of the Disorder.
Biswas D, Cary W, Nolta JA. Biswas D, et al. Int J Mol Sci. 2020 Feb 14;21(4):1286. doi: 10.3390/ijms21041286. Int J Mol Sci. 2020. PMID: 32074998 Free PMC article. Review.
Protein Phosphatase 2 Regulatory Subunit B' Delta (PPP2R5D)-related intellectual disability (ID) and neurodevelopmental delay results from germline de novo mutations in the PPP2R5D gene. This gene encodes the prote …
Protein Phosphatase 2 Regulatory Subunit B' Delta (PPP2R5D)-related intellectual dis …
PPP2R5D Genetic Mutations and Early-Onset Parkinsonism.
Walker IM, Riboldi GM, Drummond P, Saade-Lemus S, Martin-Saavedra JS, Frucht S, Bardakjian TM, Gonzalez-Alegre P, Deik A. Walker IM, et al. Ann Neurol. 2021 Jan;89(1):194-195. doi: 10.1002/ana.25943. Epub 2020 Nov 5. Ann Neurol. 2021. PMID: 33098144 No abstract available.
Clinical, neuroimaging and molecular characteristics of PPP2R5D-related neurodevelopmental disorders: an expanded series with functional characterisation and genotype-phenotype analysis.
Oyama N, Vaneynde P, Reynhout S, Pao EM, Timms A, Fan X, Foss K, Derua R, Janssens V, Chung W, Mirzaa GM. Oyama N, et al. J Med Genet. 2023 May;60(5):511-522. doi: 10.1136/jmg-2022-108713. Epub 2022 Oct 10. J Med Genet. 2023. PMID: 36216457
BACKGROUND: Variants in PPP2R5D, affecting the regulatory B56delta subunit of protein phosphatase 2A (PP2A), have been identified in individuals with neurodevelopmental abnormalities. However, the molecular and clinical spectra rem …
BACKGROUND: Variants in PPP2R5D, affecting the regulatory B56delta subunit of protein phosphatase …
Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease.
Verbinnen I, Vaneynde P, Reynhout S, Lenaerts L, Derua R, Houge G, Janssens V. Verbinnen I, et al. Biochem Soc Trans. 2021 Aug 27;49(4):1567-1588. doi: 10.1042/BST20201313. Biochem Soc Trans. 2021. PMID: 34241636 Review.
By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in cellular signalling and physiology, including in brain function …
By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse tissues, Protein Phosphatase …
B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.
Houge G, Haesen D, Vissers LE, Mehta S, Parker MJ, Wright M, Vogt J, McKee S, Tolmie JL, Cordeiro N, Kleefstra T, Willemsen MH, Reijnders MR, Berland S, Hayman E, Lahat E, Brilstra EH, van Gassen KL, Zonneveld-Huijssoon E, de Bie CI, Hoischen A, Eichler EE, Holdhus R, Steen VM, Døskeland SO, Hurles ME, FitzPatrick DR, Janssens V. Houge G, et al. J Clin Invest. 2015 Aug 3;125(8):3051-62. doi: 10.1172/JCI79860. Epub 2015 Jul 13. J Clin Invest. 2015. PMID: 26168268 Free PMC article.
Ten patients had mutations within a highly conserved acidic loop of the PPP2R5D-encoded B56delta regulatory subunit, with the same E198K mutation present in 6 individuals. ...Functional evaluation revealed that mutant A and B subunits were stabl …
Ten patients had mutations within a highly conserved acidic loop of the PPP2R5D-encoded B56delta regulatory subunit …
PPP2R5D-Related Neurodevelopmental Disorder or Developmental and Epileptic Encephalopathy?: A Novel Phenotypic Description and Review of Published Cases.
Madaan P, Kaur A, Saini L, Paria P, Vyas S, Sharma AR, Sahu JK. Madaan P, et al. Neuropediatrics. 2022 Feb;53(1):20-25. doi: 10.1055/s-0041-1733984. Epub 2021 Aug 26. Neuropediatrics. 2022. PMID: 34448180
BACKGROUND: Protein phosphatase 2 regulatory subunit B' delta (PPP2R5D)-related neurodevelopmental disorder is caused by pathogenic variations in the PPP2R5D gene, product of which is involved in dephosphorylation. .. …
BACKGROUND: Protein phosphatase 2 regulatory subunit B' delta (PPP2R5D)-related neur …
Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth.
Loveday C, Tatton-Brown K, Clarke M, Westwood I, Renwick A, Ramsay E, Nemeth A, Campbell J, Joss S, Gardner M, Zachariou A, Elliott A, Ruark E, van Montfort R; Childhood Overgrowth Collaboration; Rahman N. Loveday C, et al. Hum Mol Genet. 2015 Sep 1;24(17):4775-9. doi: 10.1093/hmg/ddv182. Epub 2015 May 13. Hum Mol Genet. 2015. PMID: 25972378 Free PMC article.
Prioritisation of functionally relevant genes with multiple unique de novo mutations revealed four mutations in protein phosphatase 2A (PP2A) regulatory subunit B family genes protein phosphatase 2, regulatory Subunit …
Prioritisation of functionally relevant genes with multiple unique de novo mutations revealed four mutations in protein phosphatas …
Reply to "PPP2R5D Genetic Mutations and Early Onset Parkinsonism".
Kim CY, Wirth T, Hubsch C, Németh AH, Okur V, Anheim M, Drouot N, Tranchant C, Rudolf G, Chelly J, Tatton-Brown K, Blauwendraat C, Vonsattel JPG, Cortes E, Alcalay RN, Chung WK. Kim CY, et al. Ann Neurol. 2021 Jan;89(1):195-196. doi: 10.1002/ana.25945. Epub 2020 Nov 11. Ann Neurol. 2021. PMID: 33098324 No abstract available.
Rare missense variants in the PPP2R5D gene associated with Parkinson's disease in the Han Chinese population.
Ning P, Li K, Ren H, Yang H, Xu Y, Yang X. Ning P, et al. Neurosci Lett. 2022 Apr 17;776:136564. doi: 10.1016/j.neulet.2022.136564. Epub 2022 Mar 4. Neurosci Lett. 2022. PMID: 35257824
OBJECTIVE: The aim of this study was to examine the frequency and spectrum of PPP2R5D mutations in a Han Chinese cohort with early- or late-onset PD. ...Two variants were predicted to be "disease-causing" by Mutation Taster, and both mutations were found to be highly conse …
OBJECTIVE: The aim of this study was to examine the frequency and spectrum of PPP2R5D mutations in a Han Chinese cohort with early- o …
33 results