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2022 13
2023 20
2024 7

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31 results

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Page 1
Precision medicine in systemic lupus erythematosus.
Fasano S, Milone A, Nicoletti GF, Isenberg DA, Ciccia F. Fasano S, et al. Nat Rev Rheumatol. 2023 Jun;19(6):331-342. doi: 10.1038/s41584-023-00948-y. Epub 2023 Apr 11. Nat Rev Rheumatol. 2023. PMID: 37041269 Review.
In particular, some genes involved in the clinical heterogeneity of SLE and some phenotype-related loci (STAT4, IRF5, PDGF genes, HAS2, ITGAM and SLC5A11) have an association with clinical features of the disease. ...
In particular, some genes involved in the clinical heterogeneity of SLE and some phenotype-related loci (STAT4, IRF5, PDGF genes, HAS …
An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.
Wang Z, Liang Q, Qian X, Hu B, Zheng Z, Wang J, Hu Y, Bao Z, Zhao K, Zhou Y, Feng X, Yi X, Li J, Shi J, Liu Z, Hao J, Chen K, Yu Y, Sham PC, Lu W, Wang X, Song W, Li MJ. Wang Z, et al. Nat Commun. 2023 Mar 3;14(1):1208. doi: 10.1038/s41467-023-36897-z. Nat Commun. 2023. PMID: 36869052 Free PMC article.
Mechanistically, the rs4728142-containing region interacts with the IRF5 alternative promoter in an allele-specific manner and orchestrates its upstream enhancer to regulate IRF5 alternative promoter usage through chromatin looping. A putative structural regulator, …
Mechanistically, the rs4728142-containing region interacts with the IRF5 alternative promoter in an allele-specific manner and orches …
Functional Genome Analysis for Immune Cells Provides Clues for Stratification of Systemic Lupus Erythematosus.
Fujio K. Fujio K. Biomolecules. 2023 Mar 25;13(4):591. doi: 10.3390/biom13040591. Biomolecules. 2023. PMID: 37189338 Free PMC article. Review.
The finding that hydroxychloroquine (HCQ), which improves the prognosis of SLE, targets toll-like receptor (TLR) signaling upstream of OXPHOS suggests the clinical importance of this pathway. IRF5 and SLC15A4, which are regulated by polymorphisms associated with SLE suscep …
The finding that hydroxychloroquine (HCQ), which improves the prognosis of SLE, targets toll-like receptor (TLR) signaling upstream of OXPHO …
Risk factors for primary Sjögren's Syndrome: a systematic review and meta-analysis.
Jin L, Dai M, Li C, Wang J, Wu B. Jin L, et al. Clin Rheumatol. 2023 Feb;42(2):327-338. doi: 10.1007/s10067-022-06474-8. Epub 2022 Dec 19. Clin Rheumatol. 2023. PMID: 36534351 Free PMC article. Review.
Significant positive relationships between infection, a family history of autoimmune disease in first-degree relatives, negative stressful life events, CGGGG insertion/deletion polymorphisms in the IRF5 gene and the onset of pSS were found, with pooled ORs and 95% CIs of 2 …
Significant positive relationships between infection, a family history of autoimmune disease in first-degree relatives, negative stressful l …
CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.
Yang C, Bachu M, Du Y, Brauner C, Yuan R, Ah Kioon MD, Chesi G, Barrat FJ, Ivashkiv LB. Yang C, et al. Nat Commun. 2022 Jun 14;13(1):3426. doi: 10.1038/s41467-022-31132-7. Nat Commun. 2022. PMID: 35701499 Free PMC article.
Mechanistically, costimulation by CXCL4 and TLR8 synergistically activates TBK1 and IKKepsilon, repurposes these kinases towards an inflammatory response via coupling with IRF5, and activates the NLRP3 inflammasome. CXCL4 signaling, in a cooperative and synergistic manner …
Mechanistically, costimulation by CXCL4 and TLR8 synergistically activates TBK1 and IKKepsilon, repurposes these kinases towards an inflamma …
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.
Han Y, Byun J, Zhu C, Sun R, Roh JY, Cordell HJ, Lee HS, Shaw VR, Kang SW, Razjouyan J, Cooley MA, Hassan MM, Siminovitch KA, Folseraas T, Ellinghaus D, Bergquist A, Rushbrook SM, Franke A, Karlsen TH, Lazaridis KN; International PSC Study Group; McGlynn KA, Roberts LR, Amos CI. Han Y, et al. Nat Commun. 2023 Feb 24;14(1):1069. doi: 10.1038/s41467-023-36678-8. Nat Commun. 2023. PMID: 36828809 Free PMC article.
Functional annotation and fine-mapping nominated several potential susceptibility genes such as MANBA and IRF5. Network-based in silico drug efficacy screening provided candidate agents for further study of pharmacological effect in PSC....
Functional annotation and fine-mapping nominated several potential susceptibility genes such as MANBA and IRF5. Network-based in sili …
Interferon regulatory factor 5-induced upregulation of zinc-finger protein 217 promotes pancreatic carcinoma progression.
Qiao X, Lv S, Qiao Y, Wang F, Miao L. Qiao X, et al. Mol Med Rep. 2022 May;25(5):189. doi: 10.3892/mmr.2022.12705. Epub 2022 Apr 1. Mol Med Rep. 2022. PMID: 35362545 Free PMC article.
Proliferation was also examined by immunofluorescence detection of Ki67 expression, and chromatin immunoprecipitation (ChIP) and luciferase reporter assays were performed to detect the interaction between ZNF217 and interferon regulatory factor 5 (I …
Proliferation was also examined by immunofluorescence detection of Ki67 expression, and chromatin immunoprecipitation (ChIP) and luciferase …
IRF5-TNOP3 polymorphisms are associated with elite control of HIV infection: A retrospective study.
Sepúlveda-Crespo D, Jiménez-Sousa MA, Fernández-Rodíguez A, Muñoz-Fernández MA, Jiménez JL, Moreno S, Garcia F, Martínez I, Benito JM, Rallón N, Resino S. Sepúlveda-Crespo D, et al. J Med Virol. 2023 Jun;95(6):e28841. doi: 10.1002/jmv.28841. J Med Virol. 2023. PMID: 37254791
Therefore, we analyzed the genetic association between IRF5-TNPO3 polymorphisms and the HIV elite control in long-term nonprogressors (LTNPs). ...IRF5-TNPO3 rs2004640, rs10954213, rs2280714, and rs10279821 polymorphisms were related to HIV elite control in LTNPs. .. …
Therefore, we analyzed the genetic association between IRF5-TNPO3 polymorphisms and the HIV elite control in long-term nonprogressors …
Interferon Regulatory Factor Family Genes: At the Crossroads between Immunity and Head and Neck Squamous Carcinoma.
Liu S, Wang Z. Liu S, et al. Dis Markers. 2022 May 26;2022:2561673. doi: 10.1155/2022/2561673. eCollection 2022. Dis Markers. 2022. PMID: 35664436 Free PMC article.
The survival analysis results showed that the overexpression of IRF1, IRF4, IRF5, IRF6, IRF8, and IRF9 was associated with better overall survival in HNSC, while the other IRFs genes (IRF2, IRF3. and IRF7) did not show prognostic values for overall survival outcome of HNSC …
The survival analysis results showed that the overexpression of IRF1, IRF4, IRF5, IRF6, IRF8, and IRF9 was associated with better ove …
Role of interferon regulatory factor 5 (IRF5) in tumor progression: Prognostic and therapeutic potential.
Roberts BK, Collado G, Barnes BJ. Roberts BK, et al. Biochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189061. doi: 10.1016/j.bbcan.2023.189061. Epub 2023 Dec 21. Biochim Biophys Acta Rev Cancer. 2024. PMID: 38141865 Review.
Canonically, the transcription factor interferon regulatory factor 5 (IRF5) is a key mediator of innate and adaptive immunity downstream of pathogen recognition receptors such as Toll-like receptors (TLRs). Hence, dysregulation of IRF5 fu …
Canonically, the transcription factor interferon regulatory factor 5 (IRF5) is a key mediator of innate a …
31 results