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2020 1
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2023 26
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Page 1
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex.
Ma S, Skarica M, Li Q, Xu C, Risgaard RD, Tebbenkamp ATN, Mato-Blanco X, Kovner R, Krsnik Ž, de Martin X, Luria V, Martí-Pérez X, Liang D, Karger A, Schmidt DK, Gomez-Sanchez Z, Qi C, Gobeske KT, Pochareddy S, Debnath A, Hottman CJ, Spurrier J, Teo L, Boghdadi AG, Homman-Ludiye J, Ely JJ, Daadi EW, Mi D, Daadi M, Marín O, Hof PR, Rasin MR, Bourne J, Sherwood CC, Santpere G, Girgenti MJ, Strittmatter SM, Sousa AMM, Sestan N. Ma S, et al. Science. 2022 Sep 30;377(6614):eabo7257. doi: 10.1126/science.abo7257. Epub 2022 Sep 30. Science. 2022. PMID: 36007006 Free PMC article.
The above molecular differences are also illustrated by expression of the neuropsychiatric risk gene FOXP2, which is human-specific in microglia and primate-specific in layer 4 granular neurons. ...
The above molecular differences are also illustrated by expression of the neuropsychiatric risk gene FOXP2, which is human-specific i …
Spatially resolved multiomics of human cardiac niches.
Kanemaru K, Cranley J, Muraro D, Miranda AMA, Ho SY, Wilbrey-Clark A, Patrick Pett J, Polanski K, Richardson L, Litvinukova M, Kumasaka N, Qin Y, Jablonska Z, Semprich CI, Mach L, Dabrowska M, Richoz N, Bolt L, Mamanova L, Kapuge R, Barnett SN, Perera S, Talavera-López C, Mulas I, Mahbubani KT, Tuck L, Wang L, Huang MM, Prete M, Pritchard S, Dark J, Saeb-Parsy K, Patel M, Clatworthy MR, Hübner N, Chowdhury RA, Noseda M, Teichmann SA. Kanemaru K, et al. Nature. 2023 Jul;619(7971):801-810. doi: 10.1038/s41586-023-06311-1. Epub 2023 Jul 12. Nature. 2023. PMID: 37438528 Free PMC article.
The results revealed their distinctive repertoire of ion channels, G-protein-coupled receptors (GPCRs) and regulatory networks, and implicated FOXP2 in the pacemaker phenotype. We show that the sinoatrial node is compartmentalized, with a core of pacemaker cells, fibroblas …
The results revealed their distinctive repertoire of ion channels, G-protein-coupled receptors (GPCRs) and regulatory networks, and implicat …
Molecular features driving cellular complexity of human brain evolution.
Caglayan E, Ayhan F, Liu Y, Vollmer RM, Oh E, Sherwood CC, Preuss TM, Yi SV, Konopka G. Caglayan E, et al. Nature. 2023 Aug;620(7972):145-153. doi: 10.1038/s41586-023-06338-4. Epub 2023 Jul 19. Nature. 2023. PMID: 37468639
We also identify human-specific regulatory changes in neuronal subtypes, which reveal human-specific upregulation of FOXP2 in only two of the neuronal subtypes. We additionally identify hundreds of new human accelerated genomic regions associated with human-specific chroma …
We also identify human-specific regulatory changes in neuronal subtypes, which reveal human-specific upregulation of FOXP2 in only tw …
FOXP2 confers oncogenic effects in prostate cancer.
Zhu X, Chen C, Wei D, Xu Y, Liang S, Jia W, Li J, Qu Y, Zhai J, Zhang Y, Wu P, Hao Q, Zhang L, Zhang W, Yang X, Pan L, Qi R, Li Y, Wang F, Yi R, Yang Z, Wang J, Zhao Y. Zhu X, et al. Elife. 2023 Sep 5;12:e81258. doi: 10.7554/eLife.81258. Elife. 2023. PMID: 37668356 Free PMC article.
Overexpression of FOXP2 aberrantly activates oncogenic MET signaling and inhibition of MET signaling effectively reverts the FOXP2-induced oncogenic phenotype. CUT&Tag assay identified FOXP2-binding sites located in MET and its associated gene HGF. Additi …
Overexpression of FOXP2 aberrantly activates oncogenic MET signaling and inhibition of MET signaling effectively reverts the FOXP2 …
Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons.
Kuo HY, Chen SY, Huang RC, Takahashi H, Lee YH, Pang HY, Wu CH, Graybiel AM, Liu FC. Kuo HY, et al. Brain. 2023 Aug 1;146(8):3542-3557. doi: 10.1093/brain/awad090. Brain. 2023. PMID: 37137515
Human speech and language are among the most complex motor and cognitive abilities. The discovery of a mutation in the transcription factor FOXP2 in KE family members with speech disturbances has been a landmark example of the genetic control of vocal communication in huma …
Human speech and language are among the most complex motor and cognitive abilities. The discovery of a mutation in the transcription factor …
In-depth characterisation of a cohort of individuals with missense and loss-of-function variants disrupting FOXP2.
Morison LD, Meffert E, Stampfer M, Steiner-Wilke I, Vollmer B, Schulze K, Briggs T, Braden R, Vogel A, Thompson-Lake D, Patel C, Blair E, Goel H, Turner S, Moog U, Riess A, Liegeois F, Koolen DA, Amor DJ, Kleefstra T, Fisher SE, Zweier C, Morgan AT. Morison LD, et al. J Med Genet. 2023 Jun;60(6):597-607. doi: 10.1136/jmg-2022-108734. Epub 2022 Nov 3. J Med Genet. 2023. PMID: 36328423 Free PMC article.
METHODS: Here we phenotyped 28 individuals from 17 families with pathogenic FOXP2-only variants (12 loss-of-function, five missense variants; 14 males; aged 2 to 62 years). ...Thus, our findings reinforce that FOXP2 provides a valuable entry point for examining the …
METHODS: Here we phenotyped 28 individuals from 17 families with pathogenic FOXP2-only variants (12 loss-of-function, five missense v …
Molecular networks of the FOXP2 transcription factor in the brain.
den Hoed J, Devaraju K, Fisher SE. den Hoed J, et al. EMBO Rep. 2021 Aug 4;22(8):e52803. doi: 10.15252/embr.202152803. Epub 2021 Jul 14. EMBO Rep. 2021. PMID: 34260143 Free PMC article. Review.
The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to two decades of empirical studies focused on uncovering its roles in the brain using a range of in vitro and in vivo methods. Here, we discus …
The discovery of the FOXP2 transcription factor, and its implication in a rare severe human speech and language disorder, has led to …
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease.
Rodríguez-Urgellés E, Casas-Torremocha D, Sancho-Balsells A, Ballasch I, García-García E, Miquel-Rio L, Manasanch A, Del Castillo I, Chen W, Pupak A, Brito V, Tornero D, Rodríguez MJ, Bortolozzi A, Sanchez-Vives MV, Giralt A, Alberch J. Rodríguez-Urgellés E, et al. Cell Mol Life Sci. 2023 Nov 21;80(12):367. doi: 10.1007/s00018-023-05015-z. Cell Mol Life Sci. 2023. PMID: 37987826 Free PMC article.
However, the role of the Foxp2 in the thalamus in HD remains unexplored. METHODS: We used two different mouse models of HD, the R6/1 and the HdhQ111 mice, to demonstrate a consistent thalamic Foxp2 reduction in the context of HD. ...In addition, reduction of thalami …
However, the role of the Foxp2 in the thalamus in HD remains unexplored. METHODS: We used two different mouse models of HD, the R6/1 …
Functional dissection of two amino acid substitutions unique to the human FOXP2 protein.
Bornschein U, Zeberg H, Enard W, Hevers W, Pääbo S. Bornschein U, et al. Sci Rep. 2023 Mar 6;13(1):3747. doi: 10.1038/s41598-023-30663-3. Sci Rep. 2023. PMID: 36879029 Free PMC article.
The transcription factor forkhead box P2 (FOXP2) is involved in the development of language and speech in humans. Two amino acid substitutions (T303N, N325S) occurred in the human FOXP2 after the divergence from the chimpanzee lineage. It has pr …
The transcription factor forkhead box P2 (FOXP2) is involved in the development of language and speech in humans …
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors.
Chen F, Byrd AL, Liu J, Flight RM, DuCote TJ, Naughton KJ, Song X, Edgin AR, Lukyanchuk A, Dixon DT, Gosser CM, Esoe DP, Jayswal RD, Orkin SH, Moseley HNB, Wang C, Brainson CF. Chen F, et al. Nat Commun. 2023 Jan 20;14(1):336. doi: 10.1038/s41467-023-35784-x. Nat Commun. 2023. PMID: 36670102 Free PMC article.
Using three-dimensional cultures and in vivo experiments, we determined that EZH2-deficient tumors were vulnerable to H3K27 demethylase or BET inhibitors. PRC2 loss/inhibition led to de-repression of FOXP2, a transcription factor that promotes migration and stemness, and …
Using three-dimensional cultures and in vivo experiments, we determined that EZH2-deficient tumors were vulnerable to H3K27 demethylase or B …
66 results