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2018 9
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72 results

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Single Cell Multiomics Identifies Cells and Genetic Networks Underlying Alveolar Capillary Dysplasia.
Guo M, Wikenheiser-Brokamp KA, Kitzmiller JA, Jiang C, Wang G, Wang A, Preissl S, Hou X, Buchanan J, Karolak JA, Miao Y, Frank DB, Zacharias WJ, Sun X, Xu Y, Gu M, Stankiewicz P, Kalinichenko VV, Wambach JA, Whitsett JA. Guo M, et al. Am J Respir Crit Care Med. 2023 Sep 15;208(6):709-725. doi: 10.1164/rccm.202210-2015OC. Am J Respir Crit Care Med. 2023. PMID: 37463497
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal developmental disorder of lung morphogenesis caused by insufficiency of FOXF1 (forkhead box F1) transcription factor function. The cellular and transcript …
Rationale: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal developmental disorder of lung morphogenes …
Foxf1 knockdown promotes BMSC osteogenesis in part by activating the Wnt/beta-catenin signalling pathway and prevents ovariectomy-induced bone loss.
Shen G, Ren H, Shang Q, Zhao W, Zhang Z, Yu X, Tang K, Tang J, Yang Z, Liang D, Jiang X. Shen G, et al. EBioMedicine. 2020 Feb;52:102626. doi: 10.1016/j.ebiom.2020.102626. Epub 2020 Jan 22. EBioMedicine. 2020. PMID: 31981979 Free PMC article.
Finally, we examined the effect of Foxf1 knockdown on the osteoblastic differentiation of human BMSCs. ...Finally, Foxf1 knockdown significantly promoted osteogenesis by human BMSCs. ...
Finally, we examined the effect of Foxf1 knockdown on the osteoblastic differentiation of human BMSCs. ...Finally, Foxf1 knock …
Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension.
Isobe S, Nair RV, Kang HY, Wang L, Moonen JR, Shinohara T, Cao A, Taylor S, Otsuki S, Marciano DP, Harper RL, Adil MS, Zhang C, Lago-Docampo M, Körbelin J, Engreitz JM, Snyder MP, Rabinovitch M. Isobe S, et al. Nat Commun. 2023 Nov 21;14(1):7578. doi: 10.1038/s41467-023-43039-y. Nat Commun. 2023. PMID: 37989727 Free PMC article.
Gene expression analysis of EC-Atm(-/-) and EC-Bmpr2(-/-) lung EC reveals reduced Foxf1, a transcription factor with selectivity for lung EC. Reducing FOXF1 in control PAEC induces DNA damage and impaired angiogenesis whereas transfection of FOXF1 in PAH PAEC …
Gene expression analysis of EC-Atm(-/-) and EC-Bmpr2(-/-) lung EC reveals reduced Foxf1, a transcription factor with selectivity for …
FOXF1 Regulates Alveolar Epithelial Morphogenesis through Transcriptional Activation of Mesenchymal WNT5A.
Reza AA, Kohram F, Reza HA, Kalin TR, Kannan PS, Zacharias WJ, Kalinichenko VV. Reza AA, et al. Am J Respir Cell Mol Biol. 2023 Apr;68(4):430-443. doi: 10.1165/rcmb.2022-0191OC. Am J Respir Cell Mol Biol. 2023. PMID: 36542853 Free PMC article.
Mutations in the FOXF1 (forkhead box F1) gene, encoding the mesenchymal FOX (forkhead box) transcription factor, are linked to alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV), a severe congenital disorder associated with the …
Mutations in the FOXF1 (forkhead box F1) gene, encoding the mesenchymal FOX (forkhead box) transcription factor, …
Forkhead box F1 functions as a novel prognostic biomarker and induces caspase-dependent apoptosis in bladder cancer.
Hao Y, He W, Wang H, Rui W, Sun F, Zhu Y, Xu D, Wang C. Hao Y, et al. Oncol Rep. 2023 Sep;50(3):173. doi: 10.3892/or.2023.8610. Epub 2023 Aug 4. Oncol Rep. 2023. PMID: 37539708 Free PMC article.
The downregulated expression of forkhead box F1 (FOXF1) has been found in many malignant tumors but no research was done in bladder cancer (BC). ...FOXF1 inhibited proliferation and induced apoptosis of BC cells via caspase signaling pathway. .. …
The downregulated expression of forkhead box F1 (FOXF1) has been found in many malignant tumors but no research …
FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma.
Milewski D, Shukla S, Gryder BE, Pradhan A, Donovan J, Sudha P, Vallabh S, Pyros A, Xu Y, Barski A, Szabo S, Turpin B, Pressey JG, Millay DP, Khan J, Kalinichenko VV, Kalin TV. Milewski D, et al. Oncogene. 2021 Mar;40(12):2182-2199. doi: 10.1038/s41388-021-01694-9. Epub 2021 Feb 24. Oncogene. 2021. PMID: 33627785 Free PMC article.
Identifying key downstream targets of PAX3-FOXO1 will provide new therapeutic opportunities for treatment of FP-RMS. Herein, we demonstrate that Forkhead Box F1 (FOXF1) transcription factor is uniquely expressed in FP-RMS and is required for FP-RMS tum …
Identifying key downstream targets of PAX3-FOXO1 will provide new therapeutic opportunities for treatment of FP-RMS. Herein, we demonstrate …
Epigenetic activation of FOXF1 confers cancer stem cell properties to cisplatin-resistant non-small cell lung cancer.
Zhao J, Xue X, Fu W, Dai L, Jiang Z, Zhong S, Deng B, Yin J. Zhao J, et al. Int J Oncol. 2020 May;56(5):1083-1092. doi: 10.3892/ijo.2020.5003. Epub 2020 Mar 4. Int J Oncol. 2020. PMID: 32319573 Free PMC article.
In this study, a novel differential methylation region located in the upstream regulatory region of the forkhead box F1 (FOXF1) gene was identified. The abnormal hypomethylation of FOXF1 increased the expression of FOXF1, and the high exp …
In this study, a novel differential methylation region located in the upstream regulatory region of the forkhead box F1 …
Prenatal Detection of a FOXF1 Deletion in a Fetus with ACDMPV and Hydronephrosis.
Bzdęga K, Kutkowska-Kaźmierczak A, Deutsch GH, Plaskota I, Smyk M, Niemiec M, Barczyk A, Obersztyn E, Modzelewski J, Lipska I, Stankiewicz P, Gajecka M, Rydzanicz M, Płoski R, Szczapa T, Karolak JA. Bzdęga K, et al. Genes (Basel). 2023 Feb 23;14(3):563. doi: 10.3390/genes14030563. Genes (Basel). 2023. PMID: 36980834 Free PMC article.
Heterozygous single-nucleotide variants or copy-number variant (CNV) deletions involving the FOXF1 gene and/or its lung-specific enhancer are found in the vast majority of ACDMPV patients. ...Here, we report a case of a prenatally detected de novo CNV deletion (~0.74 Mb) i …
Heterozygous single-nucleotide variants or copy-number variant (CNV) deletions involving the FOXF1 gene and/or its lung-specific enha …
Exome survey of individuals affected by VATER/VACTERL with renal phenotypes identifies phenocopies and novel candidate genes.
Kolvenbach CM, van der Ven AT, Kause F, Shril S, Scala M, Connaughton DM, Mann N, Nakayama M, Dai R, Kitzler TM, Schneider R, Schierbaum L, Schneider S, Accogli A, Torella A, Piatelli G, Nigro V, Capra V, Hoppe B, Märzheuser S, Schmiedeke E, Rehm HL, Mane S, Lifton RP, Dworschak GC, Hilger AC, Reutter H, Hildebrandt F. Kolvenbach CM, et al. Am J Med Genet A. 2021 Dec;185(12):3784-3792. doi: 10.1002/ajmg.a.62447. Epub 2021 Aug 2. Am J Med Genet A. 2021. PMID: 34338422 Free PMC article.
The majority of VATER/VACTERL individuals displays a renal phenotype. Hitherto, variants in FGF8, FOXF1, HOXD13, LPP, TRAP1, PTEN, and ZIC3 have been associated with the VATER/VACTERL association; however, large-scale re-sequencing could only confirm TRAP1 and ZIC3 as VATE …
The majority of VATER/VACTERL individuals displays a renal phenotype. Hitherto, variants in FGF8, FOXF1, HOXD13, LPP, TRAP1, PTEN, an …
Highly Expressed FOXF1 Inhibit Non-Small-Cell Lung Cancer Growth via Inducing Tumor Suppressor and G1-Phase Cell-Cycle Arrest.
Wu CY, Chan CH, Dubey NK, Wei HJ, Lu JH, Chang CC, Cheng HC, Ou KL, Deng WP. Wu CY, et al. Int J Mol Sci. 2020 May 2;21(9):3227. doi: 10.3390/ijms21093227. Int J Mol Sci. 2020. PMID: 32370197 Free PMC article.
However, their role in progressive regulation of non-small-cell lung cancer (NSCLC) and how these dependencies may offer opportunities for novel therapeutic options remain to be understood. Previously, we identified forkhead box F1 (FOXF1) as a reprogr …
However, their role in progressive regulation of non-small-cell lung cancer (NSCLC) and how these dependencies may offer opportunities for n …
72 results