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2022 18
2023 29
2024 8

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52 results

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Page 1
Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis.
Serio S, Pagiatakis C, Musolino E, Felicetta A, Carullo P, Laura Frances J, Papa L, Rozzi G, Salvarani N, Miragoli M, Gornati R, Bernardini G, Condorelli G, Papait R. Serio S, et al. Circ Res. 2023 Sep 29;133(8):687-703. doi: 10.1161/CIRCRESAHA.123.322676. Epub 2023 Sep 8. Circ Res. 2023. PMID: 37681309 Free article.
METHODS: To investigate the role of 3 histone modifications (H3K27ac, H3K27me3, and H3K4me1) in the metabolic remodeling occurring in the aging heart, we cross-compared epigenomic, transcriptomic, and metabolomic data from mice of different ages. In addition, the role of the tran …
METHODS: To investigate the role of 3 histone modifications (H3K27ac, H3K27me3, and H3K4me1) in the metabolic remodeling occurring in the ag …
Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity.
Chakraborty R, Ostriker AC, Xie Y, Dave JM, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA. Chakraborty R, et al. Circulation. 2022 Jun 7;145(23):1720-1737. doi: 10.1161/CIRCULATIONAHA.121.057599. Epub 2022 May 3. Circulation. 2022. PMID: 35502657
In normal aorta, p300(iKO) reduced, but CBP(iKO) enhanced, contractile protein expression and contractility compared with controls. ...TET2 coimmunoprecipitated with p300, and this interaction was enhanced by rapamycin but repressed by platelet-derived growth …
In normal aorta, p300(iKO) reduced, but CBP(iKO) enhanced, contractile protein expression and contractility compared with cont …
EGR1 induces EMT in pancreatic cancer via a P300/SNAI2 pathway.
Wang Y, Qin C, Zhao B, Li Z, Li T, Yang X, Zhao Y, Wang W. Wang Y, et al. J Transl Med. 2023 Mar 17;21(1):201. doi: 10.1186/s12967-023-04043-4. J Transl Med. 2023. PMID: 36932397 Free PMC article.
Co-IP assay was conducted to verify the interaction of EGR1 and p300/CBP. RESULTS: EGR1 was highly expressed in pancreatic cancer rather than normal pancreatic tissues and correlated with poor prognosis and cancer metastasis. ...Besides, EGR1 was positively correlated with …
Co-IP assay was conducted to verify the interaction of EGR1 and p300/CBP. RESULTS: EGR1 was highly expressed in pancreatic cancer rat …
Long noncoding RNA lncMREF promotes myogenic differentiation and muscle regeneration by interacting with the Smarca5/p300 complex.
Lv W, Jiang W, Luo H, Tong Q, Niu X, Liu X, Miao Y, Wang J, Guo Y, Li J, Zhan X, Hou Y, Peng Y, Wang J, Zhao S, Xu Z, Zuo B. Lv W, et al. Nucleic Acids Res. 2022 Oct 14;50(18):10733-10755. doi: 10.1093/nar/gkac854. Nucleic Acids Res. 2022. PMID: 36200826 Free PMC article.
Mechanistically, lncMREF interacts with Smarca5 to promote chromatin accessibility when muscle satellite cells are activated and start to differentiate, thereby facilitating genomic binding of p300/CBP/H3K27ac to upregulate the expression of myogenic regulators, such as My …
Mechanistically, lncMREF interacts with Smarca5 to promote chromatin accessibility when muscle satellite cells are activated and start to di …
EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs.
Rubio K, Molina-Herrera A, Pérez-González A, Hernández-Galdámez HV, Piña-Vázquez C, Araujo-Ramos T, Singh I. Rubio K, et al. Int J Mol Sci. 2023 Aug 1;24(15):12302. doi: 10.3390/ijms241512302. Int J Mol Sci. 2023. PMID: 37569677 Free PMC article. Review.
Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes th …
Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dys …
Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification.
Zeng Q, Wang K, Zhao Y, Ma Q, Chen Z, Huang W. Zeng Q, et al. Biomolecules. 2023 Feb 22;13(3):417. doi: 10.3390/biom13030417. Biomolecules. 2023. PMID: 36979352 Free PMC article. Review.
In recent years, p300 has been found to act as an acetyltransferase that catalyses a variety of protein modification types, such as acetylation, propanylation, butyylation, 2-hydroxyisobutyration, and lactylation. ...We review the characteristics of the p300 …
In recent years, p300 has been found to act as an acetyltransferase that catalyses a variety of protein modification types, su …
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models.
Zhong Z, Harmston N, Wood KC, Madan B, Virshup DM. Zhong Z, et al. J Clin Invest. 2022 Jun 15;132(12):e156305. doi: 10.1172/JCI156305. J Clin Invest. 2022. PMID: 35536676 Free PMC article.
Unexpectedly, the screen also identified the histone acetyltransferase EP300 (p300), but not its paralog, CREBBP (CBP). We found that EP300 is silenced due to genetic alterations in all the existing RNF43-mutant pancreatic cancer cell lines that are resistant to PORCN inhi …
Unexpectedly, the screen also identified the histone acetyltransferase EP300 (p300), but not its paralog, CREBBP (CBP). We found that …
RBBP4-p300 axis modulates expression of genes essential for cell survival and is a potential target for therapy in glioblastoma.
Mladek AC, Yan H, Tian S, Decker PA, Burgenske DM, Bakken K, Hu Z, He L, Connors MA, Carlson BL, Wilson J, Bommi-Reddy A, Conery A, Eckel-Passow JE, Sarkaria JN, Kitange GJ. Mladek AC, et al. Neuro Oncol. 2022 Aug 1;24(8):1261-1272. doi: 10.1093/neuonc/noac051. Neuro Oncol. 2022. PMID: 35231103 Free PMC article.
Thus, we investigated the hypothesis that RBBP4 interacts with p300 in a complex in glioblastoma (GBM). METHODS: shRNA silencing of RBBP4 or p300 and RNAseq was used to identify genes co-regulated by RBBP4 and p300 in GBM43 patient-derived xenograft (PDX). .. …
Thus, we investigated the hypothesis that RBBP4 interacts with p300 in a complex in glioblastoma (GBM). METHODS: shRNA silencing of R …
52 results