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Structural basis for allosteric PARP-1 retention on DNA breaks.

Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE.

Science. 2020 Apr 3;368(6486). pii: eaax6367. doi: 10.1126/science.aax6367.


Structural analyses of the Group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations.

Manenda MS, Picard MÈ, Zhang L, Cyr N, Zhu X, Barma J, Pascal JM, Couture M, Zhang C, Shi R.

J Biol Chem. 2020 Apr 3;295(14):4709-4722. doi: 10.1074/jbc.RA119.011212. Epub 2020 Feb 28.


Poly(ADP-ribose) polymerase enzymes and the maintenance of genome integrity.

Eisemann T, Pascal JM.

Cell Mol Life Sci. 2020 Jan;77(1):19-33. doi: 10.1007/s00018-019-03366-0. Epub 2019 Nov 21. Review.


Structural and functional analysis of parameters governing tankyrase-1 interaction with telomeric repeat-binding factor 1 and GDP-mannose 4,6-dehydratase.

Eisemann T, Langelier MF, Pascal JM.

J Biol Chem. 2019 Oct 4;294(40):14574-14590. doi: 10.1074/jbc.RA119.009200. Epub 2019 Aug 2.


Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.

Caron MC, Sharma AK, O'Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY.

Nat Commun. 2019 Jul 4;10(1):2954. doi: 10.1038/s41467-019-10741-9.


Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity.

Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT.

J Med Chem. 2019 Jun 13;62(11):5330-5357. doi: 10.1021/acs.jmedchem.8b01709. Epub 2019 May 24.


Signal-induced PARP1-Erk synergism mediates IEG expression.

Cohen-Armon M, Yeheskel A, Pascal JM.

Signal Transduct Target Ther. 2019 Apr 12;4:8. doi: 10.1038/s41392-019-0042-0. eCollection 2019. Review.


PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification.

Langelier MF, Eisemann T, Riccio AA, Pascal JM.

Curr Opin Struct Biol. 2018 Dec;53:187-198. doi: 10.1016/ Epub 2018 Nov 24. Review.


The comings and goings of PARP-1 in response to DNA damage.

Pascal JM.

DNA Repair (Amst). 2018 Nov;71:177-182. doi: 10.1016/j.dnarep.2018.08.022. Epub 2018 Aug 23. Review.


Hydrofluoric Acid-Based Derivatization Strategy To Profile PARP-1 ADP-Ribosylation by LC-MS/MS.

Gagné JP, Langelier MF, Pascal JM, Poirier GG.

J Proteome Res. 2018 Jul 6;17(7):2542-2551. doi: 10.1021/acs.jproteome.8b00146. Epub 2018 Jun 11.


NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains.

Langelier MF, Zandarashvili L, Aguiar PM, Black BE, Pascal JM.

Nat Commun. 2018 Feb 27;9(1):844. doi: 10.1038/s41467-018-03234-8.


The nucleosomal surface is the main target of histone ADP-ribosylation in response to DNA damage.

Karch KR, Langelier MF, Pascal JM, Garcia BA.

Mol Biosyst. 2017 Nov 21;13(12):2660-2671. doi: 10.1039/c7mb00498b.


Unfolding of core nucleosomes by PARP-1 revealed by spFRET microscopy.

Sultanov DC, Gerasimova NS, Kudryashova KS, Maluchenko NV, Kotova EY, Langelier MF, Pascal JM, Kirpichnikov MP, Feofanov AV, Studitsky VM.

AIMS Genet. 2017;4(1):21-31. doi: 10.3934/genet.2017.1.21. Epub 2017 Jan 5.


Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis.

Langelier MF, Steffen JD, Riccio AA, McCauley M, Pascal JM.

Methods Mol Biol. 2017;1608:431-444. doi: 10.1007/978-1-4939-6993-7_27.


Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors.

Chand SN, Zarei M, Schiewer MJ, Kamath AR, Romeo C, Lal S, Cozzitorto JA, Nevler A, Scolaro L, Londin E, Jiang W, Meisner-Kober N, Pishvaian MJ, Knudsen KE, Yeo CJ, Pascal JM, Winter JM, Brody JR.

Cancer Res. 2017 Sep 15;77(18):5011-5025. doi: 10.1158/0008-5472.CAN-16-2704. Epub 2017 Jul 7.


Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo.

Jeronimo C, Langelier MF, Bataille AR, Pascal JM, Pugh BF, Robert F.

Mol Cell. 2016 Nov 3;64(3):455-466. doi: 10.1016/j.molcel.2016.09.002. Epub 2016 Oct 20.


Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

Eisemann T, McCauley M, Langelier MF, Gupta K, Roy S, Van Duyne GD, Pascal JM.

Structure. 2016 Oct 4;24(10):1679-1692. doi: 10.1016/j.str.2016.07.014. Epub 2016 Sep 1.


Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage.

Steffen JD, McCauley MM, Pascal JM.

Nucleic Acids Res. 2016 Nov 16;44(20):9771-9783. Epub 2016 Aug 16.


Tankyrase Sterile α Motif Domain Polymerization Is Required for Its Role in Wnt Signaling.

Riccio AA, McCauley M, Langelier MF, Pascal JM.

Structure. 2016 Sep 6;24(9):1573-81. doi: 10.1016/j.str.2016.06.022. Epub 2016 Aug 4.


A PARP1-ERK2 synergism is required for the induction of LTP.

Visochek L, Grigoryan G, Kalal A, Milshtein-Parush H, Gazit N, Slutsky I, Yeheskel A, Shainberg A, Castiel A, Seger R, Langelier MF, Dantzer F, Pascal JM, Segal M, Cohen-Armon M.

Sci Rep. 2016 Apr 28;6:24950. doi: 10.1038/srep24950.

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