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Items: 1 to 20 of 174

1.

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes.

Xiao X, Guo P, Shiota C, Zhang T, Coudriet GM, Fischbach S, Prasadan K, Fusco J, Ramachandran S, Witkowski P, Piganelli JD, Gittes GK.

Cell Stem Cell. 2018 Jan 4;22(1):78-90.e4. doi: 10.1016/j.stem.2017.11.020.

PMID:
29304344
2.

Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas.

Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, Humar A, Husain SZ, Leach SD, Gittes GK, Esni F.

Sci Rep. 2017 Dec 13;7(1):17539. doi: 10.1038/s41598-017-17884-z.

3.

Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet.

Sheng Q, Xiao X, Prasadan K, Chen C, Ming Y, Fusco J, Gangopadhyay NN, Ricks D, Gittes GK.

Sci Rep. 2017 Nov 27;7(1):16348. doi: 10.1038/s41598-017-16485-0.

4.

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.

5.

Gcg CreERT2 knockin mice as a tool for genetic manipulation in pancreatic alpha cells.

Shiota C, Prasadan K, Guo P, Fusco J, Xiao X, Gittes GK.

Diabetologia. 2017 Dec;60(12):2399-2408. doi: 10.1007/s00125-017-4425-x. Epub 2017 Sep 7.

PMID:
28884202
6.

GLP-1/Exendin-4 induces β-cell proliferation via the epidermal growth factor receptor.

Fusco J, Xiao X, Prasadan K, Sheng Q, Chen C, Ming YC, Gittes G.

Sci Rep. 2017 Aug 22;7(1):9100. doi: 10.1038/s41598-017-09898-4.

7.

SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis-Related Diabetes.

Xiao X, Fischbach S, Zhang T, Chen C, Sheng Q, Zimmerman R, Patnaik S, Fusco J, Ming Y, Guo P, Shiota C, Prasadan K, Gangopadhyay N, Husain SZ, Dong H, Gittes GK.

Diabetes. 2017 Oct;66(10):2646-2658. doi: 10.2337/db17-0537. Epub 2017 Aug 3.

8.

Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis.

Orabi AI, Wen L, Javed TA, Le T, Guo P, Sanker S, Ricks D, Boggs K, Eisses JF, Castro C, Xiao X, Prasadan K, Esni F, Gittes GK, Husain SZ.

Cell Mol Gastroenterol Hepatol. 2017 Jan;3(1):119-128. doi: 10.1016/j.jcmgh.2016.08.006.

9.

Forkhead Box Protein 1 (FoxO1) Inhibits Accelerated β Cell Aging in Pancreas-specific SMAD7 Mutant Mice.

Xiao X, Chen C, Guo P, Zhang T, Fischbach S, Fusco J, Shiota C, Prasadan K, Dong H, Gittes GK.

J Biol Chem. 2017 Feb 24;292(8):3456-3465. doi: 10.1074/jbc.M116.770032. Epub 2017 Jan 5.

10.

Epidermal Growth Factor Receptor Signaling Regulates β Cell Proliferation in Adult Mice.

Song Z, Fusco J, Zimmerman R, Fischbach S, Chen C, Ricks DM, Prasadan K, Shiota C, Xiao X, Gittes GK.

J Biol Chem. 2016 Oct 21;291(43):22630-22637. Epub 2016 Sep 1.

11.

Effect of Hypertriglyceridemia on Beta Cell Mass and Function in ApoC3 Transgenic Mice.

Liu YZ, Cheng X, Zhang T, Lee S, Yamauchi J, Xiao X, Gittes G, Qu S, Jiang CL, Dong HH.

J Biol Chem. 2016 Jul 8;291(28):14695-705. doi: 10.1074/jbc.M115.707885. Epub 2016 May 11.

12.

A synopsis of factors regulating beta cell development and beta cell mass.

Prasadan K, Shiota C, Xiangwei X, Ricks D, Fusco J, Gittes G.

Cell Mol Life Sci. 2016 Oct;73(19):3623-37. doi: 10.1007/s00018-016-2231-0. Epub 2016 Apr 22. Review.

13.

Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis.

Cunningham KE, Vincent G, Sodhi CP, Novak EA, Ranganathan S, Egan CE, Stolz DB, Rogers MB, Firek B, Morowitz MJ, Gittes GK, Zuckerbraun BS, Hackam DJ, Mollen KP.

J Biol Chem. 2016 May 6;291(19):10184-200. doi: 10.1074/jbc.M115.688812. Epub 2016 Mar 11.

14.

PNA lectin for purifying mouse acinar cells from the inflamed pancreas.

Xiao X, Fischbach S, Fusco J, Zimmerman R, Song Z, Nebres P, Ricks DM, Prasadan K, Shiota C, Husain SZ, Gittes GK.

Sci Rep. 2016 Feb 17;6:21127. doi: 10.1038/srep21127.

15.

Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation.

Xiao X, Fischbach S, Song Z, Gaffar I, Zimmerman R, Wiersch J, Prasadan K, Shiota C, Guo P, Ramachandran S, Witkowski P, Gittes GK.

Endocrinology. 2016 Apr;157(4):1348-56. doi: 10.1210/en.2015-1986. Epub 2016 Feb 12.

16.

Dynamic imaging of pancreatic nuclear factor κB (NF-κB) activation in live mice using adeno-associated virus (AAV) infusion and bioluminescence.

Orabi AI, Sah S, Javed TA, Lemon KL, Good ML, Guo P, Xiao X, Prasadan K, Gittes GK, Jin S, Husain SZ.

J Biol Chem. 2016 Jan 15;291(3):1202. doi: 10.1074/jbc.A115.647933. No abstract available.

17.

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.

Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH.

Endocrinology. 2016 Mar;157(3):1055-70. doi: 10.1210/en.2015-1852. Epub 2016 Jan 4.

18.

Multiple roles for TGFβ receptor type II in regulating the pancreatic response in acute pancreatitis.

Gittes GK.

J Pathol. 2016 Apr;238(5):603-5. doi: 10.1002/path.4676. Epub 2016 Jan 13.

PMID:
26608971
19.

Intraislet Pancreatic Ducts Can Give Rise to Insulin-Positive Cells.

El-Gohary Y, Wiersch J, Tulachan S, Xiao X, Guo P, Rymer C, Fischbach S, Prasadan K, Shiota C, Gaffar I, Song Z, Galambos C, Esni F, Gittes GK.

Endocrinology. 2016 Jan;157(1):166-75. doi: 10.1210/en.2015-1175. Epub 2015 Oct 27.

20.

The Role of ARF6 in Biliary Atresia.

Ningappa M, So J, Glessner J, Ashokkumar C, Ranganathan S, Min J, Higgs BW, Sun Q, Haberman K, Schmitt L, Vilarinho S, Mistry PK, Vockley G, Dhawan A, Gittes GK, Hakonarson H, Jaffe R, Subramaniam S, Shin D, Sindhi R.

PLoS One. 2015 Sep 17;10(9):e0138381. doi: 10.1371/journal.pone.0138381. eCollection 2015.

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